RETRACTED: Quercetin Inhibits Tumorigenesis of Colorectal Cancer Through Downregulation of hsa_circ_0006990

Abstract

Quercetin can significantly inhibit the progression of colorectal cancer (CRC). However, its specific mechanism remains largely unclear. In this study, we aimed to explore the correlation among quercetin, tumour-associated macrophages (TAMs) and circular RNAs (circRNAs) in the progression of CRC and to present a novel strategy for the treatment of CRC. In this study, we revealed that quercetin could suppress the autophagy of M2-TAMs and induced their differentiation into M1-TAMs, by which quercetin significantly reversed the inhibition of M2-TAMS on CRC cell apoptosis and the promotion of M2-TAMS on CRC cell proliferation. Moreover, quercetin could promote the expression of downregulated hsa_circ_0006990 in CRC cells co-cultured with M2-TAMs, and the overexpression of hsa_circ_0006990 significantly reversed the anti-tumour effect of quercetin on CRC. Furthermore, we found quercetin can notably suppress the progression of CRC via mediation of the hsa_circ_0006990/miR-132-3p/MUC13 axis. In conclusion, our results suggested that quercetin inhibits the tumorigenesis of CRC via inhibiting the polarisation of M2 macrophages and downregulating hsa_circ_0006990. Our study provides useful insights for those exploring new methods of treating CRC.

The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice

“…In the study of I. W. Cheuk, resveratrol enhanced chemosensitivity by reversing macrophage polarization in breast cancer 57 . Quercetin can inhibit the autophagy of M2-TAMs and induce their differentiation to M1-TAMs, thus inhibiting the proliferation of colorectal cancer cells 58 . Studies by Jincheng Wang et al have found that curcumin is synergistic with cisplatin in the treatment of osteosarcoma by inhibiting M2-like polarization of tumor-associated macrophages.…”

Network pharmacology and bioinformatics to identify the molecular mechanisms of Gleditsiae Spina against colorectal cancer

“…Quercetin is a dietary flavonoid with antioxidant, anti-inflammatory and anticancer properties. According to related studies, quercetin inhibits the tumorigenesis of CRC by inhibiting the polarization of M2 macrophages and downregulating hsa_circ_0006990 ( Chen et al, 2022a ). As a drug, quercetin has also been studied for use in combination with drug delivery systems for the treatment of colorectal cancer.…”

Resveratrol and quercetin protect from Benzo(a)pyrene-induced autophagy in retinal pigment epithelial cells

“…Quercetin (QR) is a avonoid found in foods that is particularly abundant in onions [21]. QR has previously been reported to have protective properties against autophagy caused by M2 tumor-associated macrophages [22]. Also, QR has been shown to suppress autophagy and promote apoptosis to prevent the formation of neutrophil extracellular traps and neutrophil activitiesaccording to the experiments in rats with rheumatoid arthritis [23].…”