RETRACTED: Ligustrazine promoted hypoxia-treated cell growth by upregulation of miR-135b in human umbilical vein endothelial cells

Wei, Shu-Jing C.; Wang, Hui

doi:10.1016/j.yexmp.2018.12.005

Cited by 12 publications

(16 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chen et al [200] demonstrated that TMP at different doses of 1, 3, and 10 mg/kg interfered with 6-ohda-induced Parkinson's disease in mice which confirmed that TMP protects against dopaminergic (DA) neurodegeneration and attenuates DA neuronal apoptosis by activating the PI3K/Akt/GSK3β signaling pathway. Wei and Wang [201] found that ligustrazine alleviated hypoxiainduced HUVEC cell injury, enhanced cell viability, and inhibited cell apoptosis, all of which are related to the upregulation of miR-135b and subsequent activation of JNK/SAPK and PI3K/AKT/mTOR pathways. These events promoted hypoxia-treated HUVEC cell growth.…”

Section: Angelica Sinensis (Danggui) the Active Components Ofmentioning

confidence: 99%

New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach

Liu

Wei-liang

Gao

et al. 2019

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Aging is a progressive disease affecting around 900 million people worldwide, and in recent years, the mechanism of aging and aging-related diseases has been well studied. Treatments for aging-related diseases have also made progress. For the long-term treatment of aging-related diseases, herbal medicine is particularly suitable for drug discovery. In this review, we discuss cellular and molecular mechanisms of aging and aging-related diseases, including oxidative stress, inflammatory response, autophagy and exosome interactions, mitochondrial injury, and telomerase damage, and summarize commonly used herbals and compounds concerned with the development of aging-related diseases, including Ginkgo biloba, ginseng, Panax notoginseng, Radix astragali, Lycium barbarum, Rhodiola rosea, Angelica sinensis, Ligusticum chuanxiong, resveratrol, curcumin, and flavonoids. We also summarize key randomized controlled trials of herbal medicine for aging-related diseases during the past ten years. Adverse reactions of herbs were also described. It is expected to provide new insights for slowing aging and treating aging-related diseases with herbal medicine.

show abstract

Section: Angelica Sinensis (Danggui) the Active Components Ofmentioning

confidence: 99%

New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach

Liu

Wei-liang

Gao

et al. 2019

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Thus, various treatments and methods have been adopted to reduce the occurrence of PU as well as to raise the recovery rate . In the area of disease prevention, PU risk assessment tools are utilized for diagnosis and determining the likelihood of PU . For now, nonsurgical treatments and surgical treatments are two critical treatments .…”

Section: Introductionmentioning

confidence: 99%

“…According to Chen's report, miR‐200a contributed to proliferation, migration and PU healing in human embryonic stem cells . Moreover, downregulating miR‐135b raised viability and repressed apoptosis in hypoxia‐stimulated human umbilical vein endothelial cells . Furthermore, miR‐449a served as diverse role in diversified diseases and cells.…”

Section: Introductionmentioning

confidence: 99%

“…4 In the area of disease prevention, PU risk assessment tools are utilized for diagnosis and determining the likelihood of PU. 5 For now, nonsurgical treatments and surgical treatments are two critical treatments. 4 However, so far, the outcome of PU patients is not satisfactory.…”

mentioning

confidence: 99%

“…21 Moreover, downregulating miR-135b raised viability and repressed apoptosis in hypoxia-stimulated human umbilical vein endothelial cells. 5 Furthermore, miR-449a served as diverse role in diversified diseases and cells. For example, miR-449a was explored to play essential role in breast cancer endocrine resistance.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Circular RNA circ‐Ttc3 protects HaCaT cells from hypoxic injury by downregulation of miR‐449a

Wang

Liu

et al. 2020

IUBMB Life

View full text Add to dashboard Cite

Background Pressure ulcer (PU) is a common complication of acute and long‐time hospitalization, especially in elderly patients. The incidence and prevalence of PU are swiftly fortifying. Currently, our purpose was to investigate the functional impacts of circ‐Ttc3 on PU. Methods HaCaT cells were pretreated under hypoxia condition. Cell counting kit 8 assay and flow cytometry were utilized to test HaCaT cell viability and apoptosis. Quantitative reverse transcription polymerase chain reaction was utilized to determine circ‐Ttc3 and miR‐449a expression. Western blot was performed to examine apoptosis‐associated proteins expression. Subsequently, the above‐described investigations were reperformed after miR‐449a upregulation. Results Hypoxia induced apoptosis and declined viability in HaCaT cells. Circ‐Ttc3 expression was enhanced after transfection with circ‐Ttc3 expressing vector. Overexpressing circ‐Ttc3 raised viability and reduced apoptosis in HaCaT cells. Moreover, miR‐449a expression was elevated by hypoxia and reversed by overexpressing circ‐Ttc3. And circ‐Ttc3 exerted its effect via downregulating miR‐449a. Finally, overexpressing circ‐Ttc3 activated nuclear factor kappa‐B (NF‐κB) and phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) pathways via downregulating miR‐449a. Conclusion Our data suggested that circ‐Ttc3 alleviated hypoxic injury and activated NF‐κB and PI3K/AKT pathways by downregulating miR‐449a in HaCaT cells.

show abstract

Pharmacokinetic study on the effect of ligustrazine–tangeretin co‐administration on the pharmacokinetics of ligustrazine and its potential mechanism in rats

Liu¹,

Liu²,

Qian³

et al. 2023

Pharmacology Res & Perspec

View full text Add to dashboard Cite

Both ligustrazine and tangeretin are usually prescribed in the treatment of cardiovascular diseases, which makes their co‐administration possible. The investigation of the interaction between ligustrazine and tangeretin is necessary for the clinical compatibility of their source herbs. This study aimed to investigate the interaction of ligustrazine and tangeretin during their co‐administration. The pharmacokinetics of ligustrazine (15 mg/kg) was investigated in the presence of 50, 100, and 150 mg/kg tangeretin in rats with six of each. A single dose of ligustrazine was set as the control. The effect of tangeretin on the in vitro metabolic stability of ligustrazine was also investigated in rat liver microsomes. Tangeretin significantly reduced the system exposure of ligustrazine under all experimental concentrations. Specifically, tangeretin reduced the AUC (from 48.86 ± 12.57 to 41.02 ± 4.85 (50 mg/kg tangeretin), 31.47 ± 5.26 (100 mg/kg tangeretin), and 27.55 ± 9.60 (150 mg/kg) μg/mL × h), MRT (from 7.05 ± 0.26 to 6.33 ± 0.48, 5.53 ± 0.68, and 5.21 ± 1.31 h), Cmax (from 7.45 ± 0.44 to 6.03 ± 0.44, 5.24 ± 0.47, and 5.02 ± 0.56 μg/mL), and t1/2 (from 5.90 ± 1.27 to 4.84 ± 1.19, 3.48 ± 1.33, 3.09 ± 0.62 h) in rats. In vitro, tangeretin also reduced the metabolic stability of ligustrazine behaved as the decreased half‐life and increased intrinsic clearance rate. Co‐consumption of ligustrazine with tangeretin induced interactions, which shortens the system exposure of ligustrazine. This study provides theoretical guidance for the clinical prescription of ligustrazine‐ and tangeretin‐containing herbs.

show abstract

RETRACTED: Ligustrazine promoted hypoxia-treated cell growth by upregulation of miR-135b in human umbilical vein endothelial cells

Cited by 12 publications

References 36 publications

New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach

New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach

Circular RNA circ‐Ttc3 protects HaCaT cells from hypoxic injury by downregulation of miR‐449a

Pharmacokinetic study on the effect of ligustrazine–tangeretin co‐administration on the pharmacokinetics of ligustrazine and its potential mechanism in rats

Contact Info

Product

Resources

About