RETRACTED: Effect of nanostructure on osteoinduction of porous biphasic calcium phosphate ceramics

Li, Bo; Liao, Xiaoling; Zheng, Li; Zhu, Xiangdong; Wang, Zhe; Fan, Hongsong; Zhang, Xingdong

doi:10.1016/j.actbio.2012.06.021

Cited by 40 publications

(33 citation statements)

References 39 publications

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“…Nevertheless, besides the specific genetic factors [688] and chosen animals [690], the dissolution/precipitation behavior of CaPO 4 [700], their particle size [699], microporosity [686,690,701,702], physicochemical properties [684,686], composition [690], the specific surface area [702], nanostructure [689], as well as the surface topography and geometry [685,[703][704][705][706][707] have been pointed out as the relevant parameters. A positive effect of increased microporosity on the ectopic bone formation could be both direct and indirect.…”

Section: Osteoinductionmentioning

confidence: 99%

“…In the modern fields of the third generation bioceramics(Hench) or BIOceramics (Anderson), the full potential of CaPO 4 has only begun to be recognized. Namely, CaPO 4 , which were intended as osteoconductive bioceramics in the past, stand for materials to fabricate osteoinductive implants nowadays[152,571,596,[680][681][682][683][684][685][686][687][688][689][690][691][692][693][694][695][696][697][698][699]. Some steps in this direction have been already made by fabricating scaffolds for bone tissue engineering through the design of controlled 3D-porous structures and increasing the biological activity through development of novel ion-substituted CaPO 4…”

mentioning

confidence: 99%

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Calcium orthophosphate bioceramics

Dorozhkin¹

2015

Ceramics International

206

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Section: Osteoinductionmentioning

confidence: 99%

mentioning

confidence: 99%

Calcium orthophosphate bioceramics

Dorozhkin¹

2015

Ceramics International

206

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“…BCP is composed of two phases of hydroxyapatite (HA) and b-tricalcium phosphate (b-TCP) by adjusting their different contents. BCP could promote adhesion, proliferation and differentiation of osteocytes [16,17]. However, pure BCP has limited bone regeneration capacity; the bioactivity could be enhanced by growth factors such as recombinant bone morphogenetic protein-2 (rhBMP-2) [18].…”

Section: Introductionmentioning

confidence: 99%

Lumbar interbody fusion with porous biphasic calcium phosphate enhanced by recombinant bone morphogenetic protein-2/silk fibroin sustained-released microsphere: an experimental study on sheep model

Chen

Liu

et al. 2015

J Mater Sci: Mater Med

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Biphasic calcium phosphate (BCP) has been investigated extensively as a bone substitute nowadays. However, the bone formation capacity of BCP is limited owing to lack of osteoinduction. Silk fibroin (SF) has a structure similar to type I collagen, and could be developed to a microsphere for the sustained-release of rhBMP-2. In our previous report, bioactivity of BCP could be enhanced by rhBMP-2/SF microsphere (containing 0.5 µg rhBMP-2) in vitro. However, the bone regeneration performance of the composite in vivo was not investigated. Thus, the purpose of this study was to evaluate the efficacy of BCP/rhBMP-2/SF in a sheep lumbar fusion model. A BCP and rhBMP-2/SF microsphere was developed, and then was integrated into a BCP/rhBMP-2/SF composite. BCP, BCP/rhBMP-2 and BCP/rhBMP-2/SF were implanted randomly into the disc spaces of 30 sheep at the levels of L1/2, L3/4 and L5/6. After sacrificed, the fusion segments were evaluated by manual palpation, CT scan, biomechanical testing and histology at 3 and 6 months, respectively. The composite demonstrated a burst-release of rhBMP-2 (39.1 ± 2.8 %) on the initial 4 days and a sustained-release (accumulative 81.3 ± 4.9 %) for more than 28 days. The fusion rates, semi-quantitative CT scores, fusion stiffness in bending in all directions and histologic scores of BCP/rhBMP-2/SF were significantly greater than BCP and BCP/rhBMP-2 at each time point, respectively (P < 0.05). These findings indicate that the SF microspheres containing a very low dose of rhBMP-2 improve fusion in sheep using BCP constructs.

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“…Scaffolds with nanomaterial exhibited higher compressive strength, degradation rate, osteoconductivity, and protein absorption compared to scaffolds of submicron bioceramics [17,18]. Although HA is a nonresorbable material, nanosized HA is resorbed in association with new bone formation [19].…”

Section: Journal Of Nanomaterialsmentioning

confidence: 99%

“…When using synthetic nanoparticles as biomaterials, it is very important to regulate the aggregation/dispersion of nanoparticles. Nanoparticle of -TCP as a biological scaffold have been combined with other material [20] and sintered for coagulation [18,21]; however, dispersing effect will be insufficient. In this study, the easy regulatory process was performed; the biocompatible collagen sponge was immersed in an aqueous dispersion of nano--TCP using zwitterionic surfactants, for suppressing of nanosize particle agglutination [22,23].…”

Section: Journal Of Nanomaterialsmentioning

confidence: 99%

Osteoconductivity and Biodegradability of Collagen Scaffold Coated with Nano‐β‐TCP and Fibroblast Growth Factor 2

Ibara

Miyaji

Fugetsu

et al. 2013

Journal of Nanomaterials

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Nanoparticle bioceramics have become anticipated for biomedical applications. Highly bioactive and biodegradable scaffolds would be developed using nanoparticles of -tricalcium phosphate ( -TCP). We prepared collagen scaffolds coated by nano--TCP and fibroblast growth factor 2 (FGF2) and evaluated the effects on new bone augmentation and biodegradation. The collagen sponge was coated with the nano-TCP dispersion and freeze-dried. Scaffold was characterized by SEM, TEM, XRD, compressive testing and cell seeding. Subsequently, the nano--TCP/collagen scaffold, collagen sponge, and each material loaded with FGF2 were implanted on rat cranial bone. As a control, no implantation was performed. Nano-TCP particles were found to be attached to the fibers of the collagen sponge by SEM and TEM observations. Scaffold coated with nano-TCP showed higher compressive strength and cytocompatibility. In histological evaluations at 10 days, inflammatory cells were rarely seen around the residual scaffold, suggesting that the nano-TCP material possesses good tissue compatibility. At 35 days, bone augmentation and scaffold degradation in histological samples receiving nano--TCP scaffold were significantly greater than those in the control. By loading of FGF2, advanced bone formation is facilitated, indicating that a combination with FGF2 would be effective for bone tissue engineering.

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RETRACTED: Effect of nanostructure on osteoinduction of porous biphasic calcium phosphate ceramics

Cited by 40 publications

References 39 publications

Calcium orthophosphate bioceramics

Calcium orthophosphate bioceramics

Lumbar interbody fusion with porous biphasic calcium phosphate enhanced by recombinant bone morphogenetic protein-2/silk fibroin sustained-released microsphere: an experimental study on sheep model

Osteoconductivity and Biodegradability of Collagen Scaffold Coated with Nano‐β‐TCP and Fibroblast Growth Factor 2

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