Biochemical Pharmacology volume 79, issue 3, P330-338 2010 DOI: 10.1016/j.bcp.2009.09.003 View full text Retracted 2016-02-15Has erratum 2016-02-15
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Preetha Anand, Hareesh B. Nair, Bokyung Sung, Ajaikumar B. Kunnumakkara, Vivek R. Yadav, Rajeshwar R. Tekmal, Bharat B. Aggarwal

Abstract: Curcumin, a yellow pigment present in the spice turmeric (Curcuma longa), has been linked with antioxidant, anti-inflammatory, anti-proliferative, anticancer, antidiabetic, antirheumatic, and antiviral effects, but its optimum potential is limited by its lack of solubility in aqueous solvents and poor oral bioavailability. We employed a polymer-based nanoparticle approach to improve bioavailability. Curcumin was encapsulated with 97.5% efficiency in biodegradable nanoparticulate formulation based on poly (lac…

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