RETRACTED: Dendrimer nanocarriers as versatile vectors in gene delivery

Dutta, Tathagata; Jain, Narendra Kumar; McMillan, Nigel A.J.; Parekh, Harendra S.

doi:10.1016/j.nano.2009.05.005

Cited by 101 publications

(60 citation statements)

References 86 publications

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“…3 Compared to viral vectors, nonviral delivery has the advantages of relatively high safety and ease of use. 4,5 A variety of nonviral vectors, including those based on calcium phosphate, 6 cationic lipids, 7,8 peptides 9 and polymers, 10 have been developed over the years. Among them, cationic lipids represent one of the most widely used classes of vectors, and many transfection products based on cationic lipids are commercially available.…”

Section: Introductionmentioning

confidence: 99%

Induction of genuine autophagy by cationic lipids in mammalian cells

Man¹,

Chen²,

Zheng³

et al. 2010

Autophagy

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Section: Introductionmentioning

confidence: 99%

Induction of genuine autophagy by cationic lipids in mammalian cells

Man¹,

Chen²,

Zheng³

et al. 2010

Autophagy

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“…Because of their nanometric size, dendrimers may interact effectively and specifically with cell components such as the membrane, organelles and proteins [15,16]. Cationic dendrimers can be used as vectors for gene transfection as they have the ability to interact with various forms of nucleic acids and form complexes that protect the nucleic acid from degradation [17,18]. However, as their interactions with cell components are non-selective, dendrimers also have a potential to cause cyto-and haemotoxicity due to their terminal (e.g.…”

Section: Generationmentioning

confidence: 99%

Influence of dendrimers on red blood cells

Ziemba

Matuszko

Bryszewska

et al. 2012

Cellular and Molecular Biology Letters

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Dendrimers, highly branched macromolecules with a specific size and shape, provide many exciting opportunities for biomedical applications.However, most dendrimers demonstrate toxic and haemolytic activity because of their positively charged surface. Masking the peripheral cationic groups by coating them with biocompatible molecules is a method to reduce it. It was proven that modified dendrimers can even diminish haemolytic activity of encapsulated drugs. Experiments confirmed that anionic dendrimers are less haemotoxic than cationic ones. Due to the high affinity of dendrimers for serum proteins, presence of these components in an incubation buffer might also influence red blood cell (RBC)-dendrimer interactions and decrease the haemolysis level. Generally, haemotoxicity of dendrimers is concentration-, generation-, and time-dependent. Various changes in the RBCs' shape in response to interactions with dendrimers have been observed, from echinocytic transformations through cell aggregation to cluster formation, depending on the dendrimer's type and concentration. Understanding the physical and chemical origins of dendrimers' influences on RBCs might advance scientists' ability to construct dendrimers more suitable for medical applications.

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“…FP dendrimer systems have been studied with the scope to analyze the solubilization of hydrophobic small biomolecules involved in anti-cancer, -depressant, -inflammatory and -microbial applications [31]. This method has also been widely studied for nucleic acid-based therapeutics and other negatively charged therapeutics.…”

Section: Fp Dendrimers Systems As Enhancement Alternative Of Sensitivmentioning

confidence: 99%

Functionalized Polymers for Enhance Oral Bioavailability of Sensitive Molecules

et al. 2016

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Currently, many sensitive molecules have been studied for effective oral administration. These substances are biologically active compounds that mainly suffer early degradation in the gastrointestinal tract (GIT) and physicochemical instability, inactivation and poor solubility and permeability. The sensibility of the biomolecules has limited their oral administration in the body and today is an important research topic to achieve desired effects in medicine field. Under this perspective, various enhancement approaches have been studied as alternatives to increase their oral bioavailability. Some of these strategies include functionalized polymers to provide specific useful benefits as protection to the intestinal tract by preventing its degradation by stomach enzymes, to increase their absorption, permeability, stability, and to make a proper release in the GIT. Due to specific chemical groups, shapes and sizes, morphologies, mechanical properties, and degradation, recent advances in functionalized polymers have opened the door to great possibilities to improve the physicochemical characteristics of these biopharmaceuticals. Today, many biomolecules are found in basic studies, preclinical steps, and others are late stage clinical development. This review summarizes the contribution of functionalized polymers to enhance oral bioavailability of sensitive molecules and their application status in medicine for different diseases. Future trends of these polymers and their possible uses to achieve different formulation goals for oral delivery are also covered in this manuscript.

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RETRACTED: Dendrimer nanocarriers as versatile vectors in gene delivery

Cited by 101 publications

References 86 publications

Induction of genuine autophagy by cationic lipids in mammalian cells

Induction of genuine autophagy by cationic lipids in mammalian cells

Influence of dendrimers on red blood cells

Functionalized Polymers for Enhance Oral Bioavailability of Sensitive Molecules

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