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Cited by 10 publications
(11 citation statements)
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“…Wang Y et al. also reported that Tripterine alleviates GA by modulating miR-449a to act directly on NLRP3 mRNA and inhibit its expression ( Figure 2 ) ( 77 , 78 ).…”
Section: The Function and Mechanism Of Mirnas In Gamentioning
confidence: 93%
See 2 more Smart Citations
“…Wang Y et al. also reported that Tripterine alleviates GA by modulating miR-449a to act directly on NLRP3 mRNA and inhibit its expression ( Figure 2 ) ( 77 , 78 ).…”
Section: The Function and Mechanism Of Mirnas In Gamentioning
confidence: 93%
“…miRNAs also play a regulatory role in this process. MiR-449a and miR-192-5p can target NLRP3 and epiregulin (EREG) to inhibit macrophage M1 polarization in gout ( 77 , 79 ). Apart from this, miRNA-488-3p and -920 both can interact with the 3’UTR of IL1-β to exert anti-inflammatory effects ( 80 ).…”
Section: The Function and Mechanism Of Mirnas In Gamentioning
confidence: 99%
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“…Macrophages can be mainly divided into the classically activated M1 type and the selectively activated M2 type [ 4 ]. The immuno-inflammatory response in RA patients directly influences the polarization of macrophages in peripheral blood, synovium and synovia [ 5 , 6 ], which increases the number of M1 type pro-inflammatory macrophages, thus breaking the M1/M2 balance [ 7 ]. According to macrophage polarization research, the activation of STAT1 signal is directly related to M1 polarization [ 8 ] while the transcription regulatory mechanism of STAT1 has not been reported yet.…”
Section: Introductionmentioning
confidence: 99%
“…For instance, Evangelatos et al reported that serum miR-22 and miR-103a levels can serve as biomarkers to predict the RA-prone population (6). A recent study by Wang et al showed that miR-449 can improve gouty arthritis through its regulation of NLRP3 inflammasome activation (7). Previous studies have established that HDAC1 is a downstream target gene of miR-449, thus suggesting that miR-449 may affect the development of RA by regulating HDAC1 expression.…”
Section: Introductionmentioning
confidence: 99%