2004
DOI: 10.1007/s00280-004-0907-x View full text |Buy / Rent full text
Retracted 2004-11-5Retracted 2018-1-8
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Abstract: We have recently shown that quinoxaline 1,4-dioxide (QdNO) derivatives, namely 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide (DCQ), 2-benzoyl-3-phenyl-quinoxaline 1,4-dioxide (BPQ) and 2-acetyl-3-methyl-quinoxaline 1,4-dioxide (AMQ), suppress the growth of T-84 human colon cancer cells. Here we show that the growth-suppressive effects of QdNOs are due to their ability to induce cell cycle arrest and/or apoptosis. While AMQ blocked more than 60% of cells at the G2/M phase without inducing apoptosis, DC… Show more

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“…It is reported that some of quinoxaline 1,4-dioxide derivatives, such as echinomycin and DCQ, as anticancer agents induce apoptosis of cancer cells (Gali-Muhtasib et al, 2005;Park et al, 2006). In addition, our results contribute to our knowledge of the relationship between autophagy and apoptosis.…”
Section: Discussionsupporting
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“…It is reported that some of quinoxaline 1,4-dioxide derivatives, such as echinomycin and DCQ, as anticancer agents induce apoptosis of cancer cells (Gali-Muhtasib et al, 2005;Park et al, 2006). In addition, our results contribute to our knowledge of the relationship between autophagy and apoptosis.…”
Section: Discussionsupporting
“…In this study, we showed that DCQ is a DNA damaging and apoptotic agent that reduces the viability and colony forming ability of colon cancer cells and is non-toxic to normal intestinal cells. We have shown previously that DCQ is not toxic to normal mouse intestinal Mode K and IEC-6 cells [9] or to normal mouse mammary SCP2 cells [unpublished findings], suggesting the selectivity of this drug to cancer cells.…”
Section: Discussionmentioning
“…DCQ was found to decrease the expression levels of the hypoxia inducible factor (HIF-1α) mRNA and protein in the human colon carcinoma cell line T-84, and in EMT6 mouse mammary carcinoma cells and Lewis Lung Carcinoma (LLC) cells [4,8]. We also showed that DCQ inhibited cell proliferation and induced apoptosis in colon T-84 cancer cell lines under normoxia via the inhibition of the extracellular signal regulated kinase (ERK) phosphorylation and reduction in Bcl-2α protein [9]. While in adult T-cell leukemia, DCQ reduced cell proliferation by decreasing Tumor Growth Factor (TGF)-α, a key mediator of growth stimulation with mitogenic effects, and by increasing the mRNA and protein expression levels of the proapoptotic TGF-β1 [6].…”
Section: Introductionmentioning
“…For example, it has been reported that many types of cancer can use signals from multiple growth factor receptor for growth and survival [25,43]. The TGF receptors are intimately related with MAP-kinases mediated apoptotic pathway (JNK, p53/ Erk), whereas p53 is activated in the endpoints of the pathway [44][45][46]. The growth-inhibitory apoptotic potential and growth factor-modulator effects of maslinic acid could be related with MAP-kinases mediated apoptotic pathway [22].…”
Section: Discussionmentioning