Retracted Article: Macrophage-derived exosomes mediate osteosarcoma cell behavior by activating AKT signaling

Yan, Bin; Liu, Qingbai; Liu, Gang; Huang, Xuena; Zhu, Guangming; Gao, Luoluo; Xu, Yaozeng

doi:10.1039/c9ra07332a

Cited by 11 publications

(5 citation statements)

References 32 publications

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“…29 Macrophages are mononuclear phagocytes, which play a role in inflammation, immune regulation, wound healing, and angiogenesis. 30 Generally, macrophages are widely distributed in the body and can be polarized into M1 or M2 macrophages. Research has shown that macrophage-derived exosomes can affect the lung tissue microenvironment by affecting inflammatory signals and immune function.…”

Section: Classificationmentioning

confidence: 99%

<p>Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications</p>

Zhang¹,

Bi²,

Huang³

et al. 2020

IJN

715

624

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Exosomes are nano-sized small extracellular vesicles secreted by cells, carrying nucleic acids, proteins, lipids and other bioactive substances to play a role in the body's physiological and pathological processes. Compared to synthetic carriers such as liposomes and nanoparticles, the endogeneity and heterogeneity of exosomes give them extensive and unique advantages in the field of disease diagnosis and treatment. However, the storage stability, low yield, low purity, and weak targeting of exosomes limit its clinical application. For this reason, further exploration is needed to optimize the above problems and facilitate future functional studies of exosomes. In this paper, the origin, classification, preparation and characterization, storage stability and applications of exosome delivery system are summarized and discussed by searching a large number of literatures.

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Section: Classificationmentioning

confidence: 99%

<p>Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications</p>

Zhang¹,

Bi²,

Huang³

et al. 2020

IJN

715

624

View full text Add to dashboard Cite

show abstract

“…Tumor-derived EVs have also been reported to participate the development of multidrug resistance phenotypes with regard to sensitive OS cells [ 131 ]. Yan B. et al reported that exosomes secreted by TAMs induced proliferation and invasion of cancer cells and promoted the drug-resistance phenotype by activating the PI3K-AKT-signaling pathways in the OS cells [ 132 ] ( Figure 2 ). A recent study reported that the presence of alveolar macrophages in TME induces the secretion of OS-derived EVs [ 101 ].…”

Section: Tams and Tme In Osmentioning

confidence: 99%

Tumor-Associated Macrophages in Osteosarcoma: From Mechanisms to Therapy

Cersosimo

Lonardi

Bernardini

et al. 2020

IJMS

154

116

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Osteosarcomas (OSs) are bone tumors most commonly found in pediatric and adolescent patients characterized by high risk of metastatic progression and recurrence after therapy. Effective therapeutic management of this disease still remains elusive as evidenced by poor patient survival rates. To achieve a more effective therapeutic management regimen, and hence patient survival, there is a need to identify more focused targeted therapies for OSs treatment in the clinical setting. The role of the OS tumor stroma microenvironment plays a significant part in the development and dissemination of this disease. Important components, and hence potential targets for treatment, are the tumor-infiltrating macrophages that are known to orchestrate many aspects of OS stromal signaling and disease progression. In particular, increased infiltration of M2-like tumor-associated macrophages (TAMs) has been associated with OS metastasis and poor patient prognosis despite currently used aggressive therapies regimens. This review aims to provide a summary update of current macrophage-centered knowledge and to discuss the possible roles that macrophages play in the process of OS metastasis development focusing on the potential influence of stromal cross-talk signaling between TAMs, cancer-stem cells and additional OSs tumoral microenvironment factors.

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“…Moreover, blockage of the receptor of IL-1β restored the drug effects ( 81 ). Similarly, exosomes released by macrophages promoted proliferation, invasion and drug-resistance of osteosarcoma cells via the activation of AKT signaling, which has been widely recognized as a critical pathway mediated tumor progression ( 82 ). Those studies revealed that the secretome of macrophages might play a significant role in drug-resistance in osteosarcoma progression as in other tumors.…”

Section: Macrophages and Osteosarcomamentioning

confidence: 99%

Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy

Luo

Wang

et al. 2020

Front. Oncol.

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Osteosarcoma is a malignant primary bone tumor commonly occurring in children and adolescents. The treatment of local osteosarcoma is mainly based on surgical resection and chemotherapy, whereas the improvement of overall survival remains stagnant, especially in recurrent or metastatic cases. Tumor microenvironment (TME) is closely related to the occurrence and development of tumors, and macrophages are among the most abundant immune cells in the TME. Due to their vital roles in tumor progression, macrophages have gained increasing attention as the new target of tumor immunotherapy. In this review, we present a brief overview of macrophages in the TME and highlight the clinical significance of macrophages and their roles in the initiation and progression of osteosarcoma. Finally, we summarize the therapeutic approaches targeting macrophage, which represent a promising strategy in osteosarcoma therapies.

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Retracted Article: Macrophage-derived exosomes mediate osteosarcoma cell behavior by activating AKT signaling

Abstract: Osteosarcoma is the most common type of bone tumor, which severely threatens the health of adolescents and young adults.

Cited by 11 publications

References 32 publications

<p>Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications</p>

<p>Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications</p>

Tumor-Associated Macrophages in Osteosarcoma: From Mechanisms to Therapy

Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy

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