RETRACTED ARTICLE: Circular RNA circ-CSPP1 regulates CCNE2 to facilitate hepatocellular carcinoma cell growth via sponging miR-577

Sun, Qiang; Yu, Rui; Wang, Chunfeng; Yao, Jianning; Zhang, Lianfeng

doi:10.1186/s12935-020-01287-8

Cited by 20 publications

(16 citation statements)

References 45 publications

(42 reference statements)

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“…Several recent studies have reported the oncogenic role of circ-CSPP1 in ovarian cancer, cervical cancer, glioma, and hepatocellular carcinoma [ 21 , 22 , 23 , 24 ]. Here, our work showed a remarkable overexpression of circ-CSPP1 in CRC, in agreement with the recent work [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previous work reported the promoting effect of circ-CSPP1 on the stemness of CRC cells through the miR-193a-5p/COL1A1 axis [ 10 ]. Recent studies also identified the oncogenic role of circ-CSPP1 in human carcinogenesis by regulating the miR-361-5p/ITGB1 or miR-577/CCNE2 axis [ 22 , 24 ]. These findings suggest that there may be many other miRNA/mRNA axes that remain to be identified in the regulation of circ-CSPP1.…”

Section: Discussionmentioning

confidence: 99%

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Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis

Zhuang

Kang

et al. 2021

Open Life Sciences

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Colorectal cancer (CRC) is the third most common malignancy worldwide. Circular RNAs (circRNAs) have been implicated in cancer biology. The purpose of the current work is to investigate the precise parts of circRNA centrosome and spindle pole-associated protein 1 (circ-CSPP1) in the progression of CRC. Our data showed that circ-CSPP1 was significantly overexpressed in CRC tissues and cells. The knockdown of circ-CSPP1 attenuated cell proliferation, migration, invasion and promoted apoptosis in vitro and weakened tumor growth in vivo. circ-CSPP1 directly targeted miR-431, and circ-CSPP1 knockdown modulated CRC cell progression in vitro via upregulating miR-431. Moreover, LIM and SH3 protein 1 (LASP1) was a functional target of miR-431 in modulating CRC cell malignant progression. Furthermore, circ-CSPP1 in CRC cells functioned as a posttranscriptional regulator on LASP1 expression by targeting miR-431. Our present study identified the oncogenic role of circ-CSPP1 in CRC partially by the modulation of the miR-431/LASP1 axis, providing evidence for circ-CSPP1 as a promising biomarker for CRC management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis

Zhuang

Kang

et al. 2021

Open Life Sciences

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“…20 In addition, circ-CSPP1 contributes to HCC growth and invasion through sponging miR-577. 21 circ_0072995 was found to be the ceRNA for miR-147a and miR-30c. 12,13 In HCC, we did not observe it.…”

Section: Discussionmentioning

confidence: 99%

Circ_0072995 Promotes Proliferation and Invasion via Regulating miR-1253/EIF4A3 Signaling in HCC

He¹,

Tao²,

Xu³

et al. 2021

CMAR

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Background: Hepatocellular carcinoma (HCC) is a major threat for human health. This work aimed to determine the potential function of circ_0072995 in HCC progression and its molecular mechanism. Methods: qRT-PCR was conducted to analyze circ_0072995 expression. CCK8 and colony formation assays were utilized to detect cell proliferation. Transwell assay was performed to determine migration and invasion. Interactions among circ_0072995, miR-1253 and EIF4A3 (Eukaryotic Translation Initiation Factor 4A3) were predicted through bioinformatics methods and confirmed via luciferase reporter assay and RNA pulldown assay. Results: circ_0072995 expression was upregulated in HCC tissues. Circ_0072995 high level was associated with poor prognosis. Circ_0072995 knockdown impaired proliferation, migration, invasion and survival. MiR-1253 was sponged by circ_0072995 and targeted EIF4A3 directly. Circ_0072995 inhibited miR-1253 to upregulate EIF4A3 level. Conclusion: Circ_0072995 exerted tumorigenic roles to enhance HCC progression through activating EIF4A3 by sponging miR-1253.

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“…Numerous studies agree that the increased expression of these 5 genes is associated with a poor prognosis and more advanced tumor stages in HCC patients [ 13 , 26 – 30 ]. Moreover, research showed that E2F1 regulates DNAJA1 to promote cell proliferation and metastasis by stabilizing CDC45 in colorectal cancer cell lines [ 21 ] and that silencing CCNE2 or CENPM could inhibit HCC cell growth [ 30 , 31 ]. Therefore, CDC45 may have a synergistic relationship with NUDT1 , E2F1 , CCNE2 , MCM5 , and CENPM that promotes the oncogenesis and progression of HCC.…”

Section: Discussionmentioning

confidence: 99%

Expression of Cell Division Cycle Protein 45 in Tissue Microarrays and the CDC45 Gene by Bioinformatics Analysis in Human Hepatocellular Carcinoma and Patient Outcomes

et al. 2020

Med Sci Monit

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Background Hepatocellular carcinoma (HCC) causes a heavy disease burden worldwide. Cell division cycle 45 (Cdc45) and its encoding gene ( CDC45 ) have been studied for a long time, but their expression patterns and roles in liver carcinogenesis and advanced HCC deterioration are still incompletely understood. This study integrated tissue microarray and bioinformatics analyses to explore the expression and clinical value of CDC45 and Cdc45 in HCC. Material/Methods In HCC, the expression and relationships with clinic-pathological parameters of CDC45 and Cdc45 were investigated by integrating the RNA-sequencing data, downloaded from The Cancer Genome Atlas and Oncomine databases, and tissue microarray with immunohistochemistry staining. Co-expressed genes and genetic alterations of CDC45 separately obtained from Oncomine and cBioPortal databases were identified to shed light on the potential mechanisms of CDC45 in HCC. Results CDC45 and Cdc45 were both overexpressed in HCC tissues, and the CDC45 level progressively increased from stage I to III. The survival outcomes of the group with high CDC45 expression were significantly worse compared with the group with low expression. Amplification and deep deletion were 2 major significant alteration types in HCC patients, and the outcomes were worse in patients with altered versus unaltered CDC45 . NUDT1 , E2F1 , CCNE2 , MCM5 , and CENPM were identified as the most significantly co-expressed genes. Conclusions CDC45 and Cdc45 were both upregulated in HCC, and increased expression levels and genetic alternations of CDC45 were correlated with worse prognosis in HCC patients. CDC45 may promote HCC by co-expressing with NUDT1 , E2F1 , CCNE2 , MCM5 , and CENPM .

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RETRACTED ARTICLE: Circular RNA circ-CSPP1 regulates CCNE2 to facilitate hepatocellular carcinoma cell growth via sponging miR-577

Cited by 20 publications

References 45 publications

Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis

Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis

Circ_0072995 Promotes Proliferation and Invasion via Regulating miR-1253/EIF4A3 Signaling in HCC

Expression of Cell Division Cycle Protein 45 in Tissue Microarrays and the CDC45 Gene by Bioinformatics Analysis in Human Hepatocellular Carcinoma and Patient Outcomes

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