RETRACTED: Anastrozole or letrozole for ovulation induction in clomiphene-resistant women with polycystic ovarian syndrome: a prospective randomized trial

Badawy, Ahmed; Mosbah, Alaa; Shady, Magda

doi:10.1016/j.fertnstert.2007.05.010

Cited by 76 publications

(55 citation statements)

References 24 publications

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“…Letrozole, a highly selective AI, has been found to be effective in inducing ovulation in anovulatory and ovulatory infertile women with inadequate response to CC [14,15]. Though higher clinical pregnancy rates were observed with gonadotropins than with letrozole stimulation in CC-resistant women undergoing IUI [5,6], both groups have confirmed that letrozole is associated with acceptable pregnancy rates, cost-effectiveness, decreased side-effects and patient convenience, as compared to gonadotropins.…”

Section: Introductionmentioning

confidence: 89%

Comparison of letrozole with continuous gonadotropins and clomiphene-gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial

Ganesh

Goswami

Chattopadhyay

et al. 2009

J Assist Reprod Genet

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Purpose Letrozole, though reported to be an effective ovulation inducing agent, warrants larger randomized trials. The purpose of this study is to compare the efficacy of letrozole with that of rFSH and clomiphene citrate(CC)/rFSH for ovarian stimulation in IUI cycles. Methods Randomized, prospective, single-blinded clinical trial. 1387 PCOS women after CC failure were randomized into three groups: Group A received letrozole, Group B received CC with two doses rFSH and Group C received continuous rFSH day 2 onwards until hCG injection. Results Group A, B and C had an ovulation rate of 79.30%, 56.95% and 89.89% and cycle cancellation rate of 20.70%, 43.05% and 10.11%, respectively. Pregnancy rates in Group A, B and C were 23.39%, 14.35% and 17.92%, while the miscarriage rates were 13.80%, 16.67% and 14.52%, respectively. Conclusion Letrozole appears to be a suitable ovulation inducing agent in PCOS women with CC failure and is found to be most effective when baseline estradiol level >60 pg/ml.

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Section: Introductionmentioning

confidence: 89%

Comparison of letrozole with continuous gonadotropins and clomiphene-gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial

Ganesh

Goswami

Chattopadhyay

et al. 2009

J Assist Reprod Genet

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show abstract

“…Additionally, AIs have become an excellent alternative to clomiphene citrate treatment as ovulation inductors for the treatment of infertility, particularly in assisted reproduction programs. Letrozole, a highly selective AI, has been found to be efficacious in inducing ovulation in infertile women, especially those with an inadequate response to clomiphene citrate [7,8]. …”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Efficacy of Two Doses of Letrozole Alone or with Continuous Recombinant Follicle-Stimulating Hormone for Ovulation Induction in Anovulatory Women

Wang

Zheng²

2014

Gynecol Obstet Invest

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Aims: To determine the efficacy of letrozole alone or with recombinant follicle-stimulating hormone (rFSH) for ovarian induction in anovulatory women. Methods: A total of 322 patients undergoing intrauterine insemination (IUI) were included in this retrospective study. Letrozole (2.5 or 5.0 mg) was administered from days 5 to 9 of menses, alone or followed with rFSH started on day 9 until the day of human chorionic gonadotropin administration. A single IUI was performed 24 h after ovulation. Results: The number of follicles, endometrial thickness and serum estradiol levels were significantly higher in the letrozole + rFSH groups than in the letrozole-alone groups (p < 0.05), but no significant difference was found between the two doses of letrozole, whether alone or with rFSH. Women treated with 5.0 mg/day of letrozole + rFSH required a total dose of rFSH similar to women treated with 2.5 mg/day of letrozole + rFSH (230.77 ± 118.29 vs. 258.55 ± 130.13 IU, respectively; p = 0.205). There was no significant difference in pregnancy rates between the two doses of letrozole, whether alone or with rFSH. Conclusion: Treatment with letrozole + rFSH was more efficacious than letrozole alone for pregnancy in the IUI program; however, the effect of 5.0 mg/day of letrozole versus 2.5 mg/day of letrozole on ovulation was equivalent, regardless of whether rFSH was used.

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“…In a study, it has concluded that letrozole gave a pregnancy rate of 20-27% per cycle in PCOS women resistant to CC. More follicles developed and higher clinical pregnancy rates were reported in the longer letrozole (Mitwally and Casper, 2003;Holzer et al, 2006;Badawy et al, 2008). Tamoxifen is a triphenylethylene derivative with a structure similar to CC.…”

Section: Discussionmentioning

confidence: 99%

A Clomiphene Citrate and Letrozol Varsus Tamoxifen and Letrozole as an Infertility Treatment in Women with Polycystic Ovary Syndrome

Athar¹,

Maalhagh²,

Hosseinpoor³

et al. 2015

Pakistan J. of Biological Sciences

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RETRACTED: Anastrozole or letrozole for ovulation induction in clomiphene-resistant women with polycystic ovarian syndrome: a prospective randomized trial

Cited by 76 publications

References 24 publications

Comparison of letrozole with continuous gonadotropins and clomiphene-gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial

Comparison of letrozole with continuous gonadotropins and clomiphene-gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial

A Comparison of the Efficacy of Two Doses of Letrozole Alone or with Continuous Recombinant Follicle-Stimulating Hormone for Ovulation Induction in Anovulatory Women

A Clomiphene Citrate and Letrozol Varsus Tamoxifen and Letrozole as an Infertility Treatment in Women with Polycystic Ovary Syndrome

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