RETRACTED: Amelioration of UV radiation-induced photoaging by a combinational sunscreen formulation via aversion of oxidative collagen degradation and promotion of TGF-β-Smad-mediated collagen production

Bora, Nilutpal Sharma; Mazumder, Bhaskar; Mandal, Santa; Patowary, Pompy; Goyary, Danswrang; Chattopadhyay, Pronobesh; Dwivedi, Sanjai K.

doi:10.1016/j.ejps.2018.11.004

Cited by 20 publications

(15 citation statements)

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“…These components were reported to possess a potent antioxidant effect. These ndings were in partial agreement with those of [38].…”

Section: Discussionsupporting

confidence: 86%

Brain-Derived Neurotropic Factor (BDNF) Mediates the Protective Effect of L.Cucurbita Pepo on Salivary Glands of Depressed Rat Evident by Structural, Biochemical and Molecular Study

Hm¹,

Ea²,

Zm³

et al. 2021

Preprint

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BackgroundAcute and chronic stresses affect the salivary glands which are the source of plasma BDNF during stressful conditions. Pumpkin is a medicinal plant with an evident antioxidant, anti-inflammatory and potential antidepressant effects. This work was conducted to assess the impact of chronic unpredictable mild stress (CUMS) on the structure of albino rats’ salivary glands and evaluate the role of pumpkin extract (Pump) in ameliorating this effect. MethodsFour groups (n=10 each) of male albino rats included in this study; the control, CUMS, CUMS+ﬂuoxetine and (CUMS+Pump). Corticosterone, pro-inflammatory cytokines (TNF-α & IL-6) and the oxidant/antioxidant profile were all assessed in the serum. BDNF mRNA level was measured in the salivary glands using qRT-PCR. Histopathological changes of the salivary glands were also assessed. ResultsDepression was confirmed behaviorally and biochemically. Exposure to CUMS significantly (p< 0.001) up-regulated the level of serum corticosterone. CUMS induced degenerative changes in the secretory and ductal system, atrophy of acini and increased apoptosis of the acinar and ductal cells. Both fluoxetine and Pump significantly up-regulated (p<0.001) BDNF expression in the salivary glands and ameliorated the CUMS-induced histopathological alterations in the salivary glands. Pumpkin significantly (p<0.001) increased the serum levels of antioxidant enzymes SOD, GPX and CAT and reduced the serum levels of the pro-inflammatory cytokines TNF-α, IL-6.ConclusionPumpkin ameliorates chronic stress-induced depression in rats by exerting a promising anti-inflammatory, antioxidant and anti-depressant-like effects in rats exposed to CUMS. Pump subsequently improved stress-induced structural changes in the salivary glands that might be due to the glands up-regulation of BDNF expression.Trial registrationNot applicable.

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“…These components were reported to possess a potent antioxidant effect. These ndings were in partial agreement with those of [38].…”

Section: Discussionsupporting

confidence: 86%

Brain-Derived Neurotropic Factor (BDNF) Mediates the Protective Effect of L.Cucurbita Pepo on Salivary Glands of Depressed Rat Evident by Structural, Biochemical and Molecular Study

Hm¹,

Ea²,

Zm³

et al. 2021

Preprint

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“…[ 29 ] Bora et al reported a significant reduction of in vivo antioxidant capacity of the skin following chronic exposure of experimental animals to broad-spectrum UV radiation. [ 30 ] They also observed a statistically significant increase in CAT, SOD, and GPx following the use of the formula of melatonin and pumpkin seed oil. Moreover, this was evident in this study as the application of PE for 2 weeks resulted in a significant increase in skin activity of CAT, SOD, and GPx.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of sweet pumpkin in relieving contact dermatitis in chronically stressed rats

Huwait

2020

J Microsc Ultrastruct

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Background: Contact dermatitis (CD) is considered among the common inflammatory skin diseases worldwide. Cucurbita moschata Duchesne has antioxidant, anti-inflammatory, and antidepressant activity beside many other beneficial effects. Objectives: This study aimed to assess the effect of pumpkin fruit extract in treating CD in mice exposed to chronic stress and to explore the mechanism through which pumpkin can relief these changes. Materials and Methods: Thirty male albino rats were divided into three groups ( n = 10); the control and two experimental groups that were exposure to chronic unpredictable mild stress for 4 weeks then painting with 1-fluoro-2,4-dinitrofluorobenzene (DNFB) for 3 consecutive days/week for 2 weeks to induce CD. Biochemical assessment of corticosterone level and antioxidants activity was performed. Skin of affected areas was excised, processed for histopathological examination. Results: DNFB-induced CD presented with dryness, hardness, and scaling. There was a significant reduction ( P < 0.001) in the levels of superoxide dismutase, glutathione peroxidase and catalase activity in the skin of rats had CD. Histopathologically, the shin showed hyperplastic-thickened epidermis, focal elongation of the rete ridges, inflammatory cells infiltration in the superficial dermis, and increased collagen fibers. Local administration of pumpkin extract significantly increased the antioxidants activity in the skin and alleviated the CD-associated changes. Conclusions: This study showed that the pumpkin fruit extract could have a potential in treating CD in stressed conditions mainly via its enhancement of skin antioxidant activity.

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“…These findings are in partial agreement with those of Bardaa et al and Kim et al [15,48] who found that palmitic acid, oleic acid and linoleic acid represent the main fatty acids in pumpkin (Cucurbita pepo L.) oil seeds and account in total for about 90%. In their recent study, Bora et al [49] reported that pumpkin (Cucurbita pepo) seed oil possesses a lipid profile, which comprises of 43-53% of linoleic acid and two classes of antioxidant compounds, namely; tocopherols and phenolics, which account for 59% of the antioxidant effects.…”

Section: Discussionmentioning

confidence: 99%

L. Cucurbita pepo modulates contact dermatitis in depressed rats through downregulation of proinflammatory cytokines and upregulation of antioxidant status

Ayuob¹,

Hawuit²,

Mohammedsaleh³

et al. 2022

pdia

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Introduction: The link between psychological stress and skin diseases, such as atopic dermatitis is established. Pumpkin was proved to have antioxidant, anti-inflammatory and accelerating wound healing potential. Aim: To assess the efficacy of pumpkin fruit (Cucurbita pepo L.) extract (PE) in relieving contact dermatitis (CD) in depressed rats compared to a standard treatment of CD and explore the mechanism behind this effect. Material and methods: Thirty male albino rats were exposed to chronic unpredictable mild stress (CUMS) for 4 weeks for induction of depression, then exposed to 1-fluoro-2,4-dinitrofluorobenzene (DNFB) for 2 weeks for induction of CD. The rats were then divided into 3 groups (n = 10 each); the positive control, Betamethasone-treated, and PE-treated groups. Depression was confirmed by the forced swim test and measuring the serum corticosterone level. Proinflammatory cytokines tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were measured in the skin and serum and their mRNA levels were assessed using qRT-PCR. Oxidant/antioxidant profile including levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) was assessed in the skin and serum. Histopathological assessment of skin samples was performed and CD4 and CD68 immunoexpression was assessed. Results: The used PE included a large amount of oleic acid (about 56%) and a small amount of linoleic acid (about 1%). The topical application of PE significantly attenuated inflammation and oxidative changes attributed to CD associated with chronic stress-induced depression comparable to the standard treatment of CD. PE significantly alleviated signs and histopathological score of CD (p < 0.001) through the significant down-regulation of proinflammatory cytokines and the significant up-regulation of antioxidants in the skin. Significant down-regulation (p < 0.001) of TNF-α, IL-6, COX-2 and iNOS gene expression in the PE-treated group confirmed the anti-inflammatory action of PE. Conclusions: The pumpkin extract, applied topically in CD associated with depression, could be an alternative as well as preventive approach in treating CD. Anti-inflammatory and antioxidants activity of pumpkin is a proposed mechanism behind this effect. Further studies to test this effect on volunteer patients of CD are recommended.

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RETRACTED: Amelioration of UV radiation-induced photoaging by a combinational sunscreen formulation via aversion of oxidative collagen degradation and promotion of TGF-β-Smad-mediated collagen production

Cited by 20 publications

References 56 publications

Brain-Derived Neurotropic Factor (BDNF) Mediates the Protective Effect of L.Cucurbita Pepo on Salivary Glands of Depressed Rat Evident by Structural, Biochemical and Molecular Study

Brain-Derived Neurotropic Factor (BDNF) Mediates the Protective Effect of L.Cucurbita Pepo on Salivary Glands of Depressed Rat Evident by Structural, Biochemical and Molecular Study

Efficacy of sweet pumpkin in relieving contact dermatitis in chronically stressed rats

L. Cucurbita pepo modulates contact dermatitis in depressed rats through downregulation of proinflammatory cytokines and upregulation of antioxidant status

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