Biochemical Pharmacology volume 78, issue 9, P1127-1138 2009 DOI: 10.1016/j.bcp.2009.06.022 View full text
Sue Ellen Touma, Sven Perner, Mark A. Rubin, David M. Nanus, Lorraine J. Gudas

Abstract: AbstractRetinoids, which include vitamin A (retinol) and metabolites such as retinoic acid, can inhibit tumor growth and reverse carcinogenesis in animal models of prostate cancer. We analyzed retinoid signaling and metabolism in the TRAMP (Transgenic Adenocarcinoma Mouse Prostate) model. We detected increased retinol and retinyl esters in prostates pooled from 24-36 week TRAMP transgenic positive mice compared to nontransgenic littermates by HPLC. We used quantitative RT-PCR to measure transcripts for genes …

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