Retinochoroidal Collateral Veins Protect Against Anterior Segment Neovascularization After Central Retinal Vein Occlusion

Abstract

To test the hypothesis that retinochoroidal collateral veins (RCVs), or alternatively, retinociliary or optociliary shunts/collaterals/veins or opticociliary anastomoses, act protectively against the development of anterior segment neovascularization (ASN) following central retinal vein occlusion (CRVO). Design: Case-control retrospective medical record review of patients with CRVO. Patients: We identified 107 patients with CRVO, of whom 34 had developed ASN, by reviewing their medical records. After applying exclusion criteria, a case group and an age-, sex-, and visual acuity-matched control group were selected. We analyzed these groups for the presence or absence of RCVs and noted the time course involved in their development. Main Outcome Measures: Anterior segment neovascularization (including neovascularization of the iris and/or anterior chamber angle), neovascular glaucoma, and RCV development.

Radial Optic Neurotomy for Central Retinal Vein Occlusion: Long-Term Retinal Perfusion Outcome

“…However, we have no reliable data on how frequently spontaneous anastomosis occurs after an occlusion. Fuller et al [20 ]described a 46% incidence of spontaneous CRA after CRVO, and in the literature, the incidence of CRA after RON ranges from 42.9 to 60% [7, 21, 22]. In our study, 16 (57.1%) cases developed CRA after surgery compared to 2 (5.7%) controls.…”

Radial Optic Neurotomy for Central Retinal Vein Occlusion: Long-Term Retinal Perfusion Outcome

“…However, we have no reliable data on how frequently spontaneous anastomosis occurs after an occlusion. Fuller et al [20 ]described a 46% incidence of spontaneous CRA after CRVO, and in the literature, the incidence of CRA after RON ranges from 42.9 to 60% [7, 21, 22]. In our study, 16 (57.1%) cases developed CRA after surgery compared to 2 (5.7%) controls.…”

Radial Optic Neurotomy for Management of Hemicentral Retinal Vein Occlusion

“…14 In addition, their location close to the optic nerve renders them more effective. The time of appearance of spontaneous cilioretinal collateral vessels is not well established, ranging from 2 to 25 months (mean, 6.7 months), according to Fuller et al 17 in patients with CRVO, a duration much longer than that induced by radial optic neurotomy, which is about 6 weeks. Thus, we strongly believe that the anastomoses in these cases were directly related to radial optic neurotomy.…”

“…Financial Disclosure: None. Previous Presentation: This study was presented in part as a poster at the annual meeting of the American Academy of Ophthalmology; November [15][16][17][18]2003; Anaheim, Calif.…”

Radial Optic Neurotomy in Central Retinal Vein Occlusion: Preliminary Results

“…The VA outcome of the eyes with CRVO that developed optociliary venous anastomosis was not significantly different from the VA of the eyes without optociliary venous anastomosis. On the other hand, other studies [23][24][25] revealed that development of optociliary venous anastomosis is correlated with better visual prognosis. Development of optociliary venous anastomosis is claimed to be a possible mechanism of clinical improvement in RON.…”

Radial Optic Neurotomy for Central Retinal Vein Occlusion: Long-Term Retinal Perfusion Outcome

“…However, we have no reliable data on how frequently spontaneous anastomosis occurs after an occlusion. Fuller et al [20 ]described a 46% incidence of spontaneous CRA after CRVO, and in the literature, the incidence of CRA after RON ranges from 42.9 to 60% [7, 21, 22]. In our study, 16 (57.1%) cases developed CRA after surgery compared to 2 (5.7%) controls.…”

Radial Optic Neurotomy for Management of Hemicentral Retinal Vein Occlusion

“…14 In addition, their location close to the optic nerve renders them more effective. The time of appearance of spontaneous cilioretinal collateral vessels is not well established, ranging from 2 to 25 months (mean, 6.7 months), according to Fuller et al 17 in patients with CRVO, a duration much longer than that induced by radial optic neurotomy, which is about 6 weeks. Thus, we strongly believe that the anastomoses in these cases were directly related to radial optic neurotomy.…”

“…Financial Disclosure: None. Previous Presentation: This study was presented in part as a poster at the annual meeting of the American Academy of Ophthalmology; November [15][16][17][18]2003; Anaheim, Calif.…”

Radial Optic Neurotomy in Central Retinal Vein Occlusion: Preliminary Results

“…The VA outcome of the eyes with CRVO that developed optociliary venous anastomosis was not significantly different from the VA of the eyes without optociliary venous anastomosis. On the other hand, other studies [23][24][25] revealed that development of optociliary venous anastomosis is correlated with better visual prognosis. Development of optociliary venous anastomosis is claimed to be a possible mechanism of clinical improvement in RON.…”

Radial Optic Neurotomy for Central Retinal Vein Occlusion: Long-Term Retinal Perfusion Outcome

“…However, we have no reliable data on how frequently spontaneous anastomosis occurs after an occlusion. Fuller et al [20 ]described a 46% incidence of spontaneous CRA after CRVO, and in the literature, the incidence of CRA after RON ranges from 42.9 to 60% [7, 21, 22]. In our study, 16 (57.1%) cases developed CRA after surgery compared to 2 (5.7%) controls.…”

Radial Optic Neurotomy for Management of Hemicentral Retinal Vein Occlusion

“…14 In addition, their location close to the optic nerve renders them more effective. The time of appearance of spontaneous cilioretinal collateral vessels is not well established, ranging from 2 to 25 months (mean, 6.7 months), according to Fuller et al 17 in patients with CRVO, a duration much longer than that induced by radial optic neurotomy, which is about 6 weeks. Thus, we strongly believe that the anastomoses in these cases were directly related to radial optic neurotomy.…”

“…Financial Disclosure: None. Previous Presentation: This study was presented in part as a poster at the annual meeting of the American Academy of Ophthalmology; November [15][16][17][18]2003; Anaheim, Calif.…”

Radial Optic Neurotomy in Central Retinal Vein Occlusion: Preliminary Results

“…The VA outcome of the eyes with CRVO that developed optociliary venous anastomosis was not significantly different from the VA of the eyes without optociliary venous anastomosis. On the other hand, other studies [23][24][25] revealed that development of optociliary venous anastomosis is correlated with better visual prognosis. Development of optociliary venous anastomosis is claimed to be a possible mechanism of clinical improvement in RON.…”