1950
DOI: 10.1001/archopht.1950.00910020074006
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Retinoblastoma

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“…23 In another autopsy study of 17 patients by Merriam, it was noted that all cases with evidence of invasion of skull bones, distant bones, and viscera had evidence of choroidal tumor infiltration. 24 In their study of 42 retinoblastoma cases, Redler and Ellsworth emphasized the importance of correlation between the volume of choroidal invasion and systemic metastasis. 25 In their study, 5 of the 26 cases (19%) with choroidal tumor infiltration developed metastasis, and there was a strong correlation between the increasing volume of choroidal invasion and systemic metastasis.…”
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confidence: 99%