Retinoblastoma—comparative analysis of external radiotherapy techniques, including an IMRT technique

Reisner, Márcio Lemberg; Viégas, Célia M.; Grazziotin, Rachele; Batista, Delano V. S.; Carneiro, Túlio Meneses; Araújo, Carlos; Marchiori, Edson

doi:10.1016/j.ijrobp.2006.09.057

Cited by 31 publications

(20 citation statements)

References 43 publications

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“…[29, 32, 33] However, many of the patients in these studies were treated using older radiation techniques, and it is likely that rates of hypoplasia are lower with IMRT-based techniques. [34, 35] For example, in a recent study of 13 patients treated with chemotherapy and IMRT for head and neck rhabdomyosarcoma, seven developed facial hypoplasia. [36] In all PRT cases in this study, a single lateral or lateral-oblique field was used, thus exposing only a limited volume of the lateral orbit to radiation.…”

Section: Discussionmentioning

confidence: 99%

Analysis of patient outcomes following proton radiation therapy for retinoblastoma

Mouw

Yeap

Caruso

et al. 2017

Advances in Radiation Oncology

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PurposeProton radiation therapy (PRT) is used to treat patients with retinoblastoma (RB) and has the potential to minimize exposure of normal tissue to radiation and thus decrease the risk of toxicity and second malignancies. However, comprehensive analyses of long-term patient outcomes are not available.Methods and materialsPatients with RB who were treated with PRT at our institution between 1986 and 2012 were invited to participate in a study that was designed to assess long-term outcomes. Patients who were enrolled in the study underwent a comprehensive analysis that included oncologic, ophthalmic, endocrine, cephalometric, and quality of life (QOL) assessments.ResultsA total of 12 patients were enrolled in this study. The average length of follow-up was 12.9 years (range, 4.8-22.2 years). All study patients had bilateral disease, and the disease and visual outcomes were similar to the outcomes for all patients with RB who were treated with PRT over the same time period at our institution. An analysis of endocrine-related test results revealed no growth abnormalities or hormonal deficiencies across the cohort. Magnetic resonance imaging scans and external cephalometry showed that PRT was associated with less facial hypoplasia than enucleation. Patient and parent-proxy QOL assessments revealed that treatment for RB did not appear to severely affect long-term QOL.ConclusionsIn addition to providing an opportunity for long-term disease control and functional eye preservation, PRT does not appear to be associated with unexpected late visual, endocrine, or QOL effects in this cohort of patients with RB.

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Section: Discussionmentioning

confidence: 99%

Analysis of patient outcomes following proton radiation therapy for retinoblastoma

Mouw

Yeap

Caruso

et al. 2017

Advances in Radiation Oncology

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“…A review of EBR technology revealed that the lateral field is usually used because it requires lower lens doses (2-7). In most cases, radiation-induced cataract is not an obstacle to the vision preservation.…”

Section: Discussionmentioning

confidence: 99%

“…Because treatments for retinoblastoma cure over 90% of patients, organ and vision preservation and the minimization of late treatment side-effects are important secondary treatment goals. Retinoblastoma had been treated by external beam radiotherapy (EBR), and for many years this was the accepted treatment standard (2-7). However, greater knowledge of radiation induced morbidities and of secondary tumor risks after radiation therapy (8, 9) have encouraged the use of primary chemotherapy plus conservative focal therapy over the past decade.…”

Section: Introductionmentioning

confidence: 99%

Long Term Follow-up Results of External Beam Radiotherapy as Primary Treatment for Retinoblastoma

et al. 2010

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The authors reviewed their experiences of external beam radiotherapy (EBR) as an initial treatment in retinoblastoma patients to determine its long-term effect on subsequent tumor control and complications. A total of 32 eyes in 25 patients that underwent EBR for retinoblastoma were reviewed retrospectively. The patients consisted of 21 boys and 4 girls of median age at treatment of 7.1 months. Radiation doses ranged from 35 to 59.4 Gy. The 10-yr ocular and patient survivals were 75.4% and 92.3%, respectively. Nine of the 32 eyes progressed; 7 of these were enucleated and 2 were salvaged by focal treatment. According to the Reese-Ellsworth classification, 4 of 5 eyes of Group II, 13 of 16 Group III eyes, 2 of 4 Group IV eyes, and 5 of 7 Group V eyes were retained, and of the 32 eyes, 13 had visual acuity better than 20/200. Eleven patients experienced a radiation-induced complication. No patient developed a second malignancy during follow-up. Despite the limited number of patients enrolled, EBR may provide a mean of preserving eyeball and vision for some advanced lesions.

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“…This allows for greater conformality of isodose distributions to treatment targets, sculpting distributions to avoid nearby critical structures, the potential for dose escalation and reduction of radiotherapy side effects ( fig. 2) [18][19][20].…”

Section: Treatment Planningmentioning

confidence: 99%

“…Helium ion therapy is similar to proton therapy because helium ions are heavily charged particles that have a prominent Bragg peak, optimal for treatment of smaller ophthalmic malignancies [63][64][65][66][67][68]. 20 30 Fig. 7.…”

Section: Energy Distributionmentioning

confidence: 99%

Teletherapy: Advanced Techniques

Stockham

Balagamwala

Singh

et al. 2013

Ophthalmic Radiation Therapy

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Radiotherapy has been utilized as a treatment for ophthalmologic processes for more than one hundred years. Over this century, the field of ophthalmologic oncology has been revolutionized through medical discoveries, development of novel surgical interventions, and innovation of advanced radiotherapy techniques. In this chapter, novel radiotherapy techniques are considered. Material presented will build on basic radiation therapy principles, techniques, and treatment parameters established in the previous chapter through consideration of intensity modulated radiotherapy, stereotactic radiotherapy, and heavy ion therapy. Deliberation of matters common across advanced radiotherapy techniques including target delineation, treatment planning, and requisites for ensuring accurate, precise treatment delivery will precede discussion of advanced radiotherapy techniques as applied to the management ophthalmologic malignancies.

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Retinoblastoma—comparative analysis of external radiotherapy techniques, including an IMRT technique

Cited by 31 publications

References 43 publications

Analysis of patient outcomes following proton radiation therapy for retinoblastoma

Analysis of patient outcomes following proton radiation therapy for retinoblastoma

Long Term Follow-up Results of External Beam Radiotherapy as Primary Treatment for Retinoblastoma

Teletherapy: Advanced Techniques

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