Retinoblastoma

Retinoblastoma in Chinese Children Aged Five to Fourteen Years

“…As a corollary, our findings complement reports on the diagnosis of retinoblastoma in adults. In 1929, Verhoeff [8] reported on a histopathologically confirmed retinoblastoma in a 48-year-old man, and McCrea [20] published on a newly diagnosed retinoblastoma in a 67-year-old patient. It has been assumed that in elderly patients with retinoblastomas, the disease was presumably sporadic [9].…”

“…In previous large-scale studies, approximately 95% of all retinoblastomas had been diagnosed at an age of less than 5 years [1,2,3,4,5,6,7]. Retinoblastomas have only rarely been detected in children aged 5 years or older, and they may then present with atypical features, posing a diagnostic challenge and potentially leading to a masquerade syndrome [8,9,10,11,12,13,14]. It has also been discussed that retinoblastomas detected in children aged 5 years or older may have different biologic properties and a different prognosis from those of tumors when detected earlier in life [13].…”

Retinoblastoma in Chinese Children Aged Five to Fourteen Years

“…As a corollary, our findings complement reports on the diagnosis of retinoblastoma in adults. In 1929, Verhoeff [8] reported on a histopathologically confirmed retinoblastoma in a 48-year-old man, and McCrea [20] published on a newly diagnosed retinoblastoma in a 67-year-old patient. It has been assumed that in elderly patients with retinoblastomas, the disease was presumably sporadic [9].…”

“…In previous large-scale studies, approximately 95% of all retinoblastomas had been diagnosed at an age of less than 5 years [1,2,3,4,5,6,7]. Retinoblastomas have only rarely been detected in children aged 5 years or older, and they may then present with atypical features, posing a diagnostic challenge and potentially leading to a masquerade syndrome [8,9,10,11,12,13,14]. It has also been discussed that retinoblastomas detected in children aged 5 years or older may have different biologic properties and a different prognosis from those of tumors when detected earlier in life [13].…”

Going the distance with cyclodiode laser

“…Cyclodestructive procedures which were utilised in the management of refractory glaucoma have been available for the past 100 years. The initial procedures described were those of cyclectomy 1 and cyclodiathermy 2 . These gained favour during the first half of the last century; however, audits found very low efficacy with an unacceptable number of complications 3 .…”

Retinoblastoma

“…Almost 35 years later, Flexner 20 and Wintersteiner 21 reported the resemblance of the tumor rosettes to photoreceptors of the adult retina. In the 1920s, Verhoeff 22 believed that the tumor arose from embryonic retinal cells and proposed the name "retinoblastoma." The subject of histogenesis lay moot for decades until the late 1960s, when Ts'o and associates 23,24 studied the ultrastructural features of more differentiated tumors and found clear evidence of photoreceptor differentiation.…”

Retinoblastoma in Chinese Children Aged Five to Fourteen Years

“…As a corollary, our findings complement reports on the diagnosis of retinoblastoma in adults. In 1929, Verhoeff [8] reported on a histopathologically confirmed retinoblastoma in a 48-year-old man, and McCrea [20] published on a newly diagnosed retinoblastoma in a 67-year-old patient. It has been assumed that in elderly patients with retinoblastomas, the disease was presumably sporadic [9].…”

“…In previous large-scale studies, approximately 95% of all retinoblastomas had been diagnosed at an age of less than 5 years [1,2,3,4,5,6,7]. Retinoblastomas have only rarely been detected in children aged 5 years or older, and they may then present with atypical features, posing a diagnostic challenge and potentially leading to a masquerade syndrome [8,9,10,11,12,13,14]. It has also been discussed that retinoblastomas detected in children aged 5 years or older may have different biologic properties and a different prognosis from those of tumors when detected earlier in life [13].…”

Going the distance with cyclodiode laser

“…Cyclodestructive procedures which were utilised in the management of refractory glaucoma have been available for the past 100 years. The initial procedures described were those of cyclectomy 1 and cyclodiathermy 2 . These gained favour during the first half of the last century; however, audits found very low efficacy with an unacceptable number of complications 3 .…”

Retinoblastoma

“…Almost 35 years later, Flexner 20 and Wintersteiner 21 reported the resemblance of the tumor rosettes to photoreceptors of the adult retina. In the 1920s, Verhoeff 22 believed that the tumor arose from embryonic retinal cells and proposed the name "retinoblastoma." The subject of histogenesis lay moot for decades until the late 1960s, when Ts'o and associates 23,24 studied the ultrastructural features of more differentiated tumors and found clear evidence of photoreceptor differentiation.…”

Retinoblastoma in Chinese Children Aged Five to Fourteen Years

“…As a corollary, our findings complement reports on the diagnosis of retinoblastoma in adults. In 1929, Verhoeff [8] reported on a histopathologically confirmed retinoblastoma in a 48-year-old man, and McCrea [20] published on a newly diagnosed retinoblastoma in a 67-year-old patient. It has been assumed that in elderly patients with retinoblastomas, the disease was presumably sporadic [9].…”

“…In previous large-scale studies, approximately 95% of all retinoblastomas had been diagnosed at an age of less than 5 years [1,2,3,4,5,6,7]. Retinoblastomas have only rarely been detected in children aged 5 years or older, and they may then present with atypical features, posing a diagnostic challenge and potentially leading to a masquerade syndrome [8,9,10,11,12,13,14]. It has also been discussed that retinoblastomas detected in children aged 5 years or older may have different biologic properties and a different prognosis from those of tumors when detected earlier in life [13].…”

Going the distance with cyclodiode laser

“…Cyclodestructive procedures which were utilised in the management of refractory glaucoma have been available for the past 100 years. The initial procedures described were those of cyclectomy 1 and cyclodiathermy 2 . These gained favour during the first half of the last century; however, audits found very low efficacy with an unacceptable number of complications 3 .…”

Retinoblastoma

“…Almost 35 years later, Flexner 20 and Wintersteiner 21 reported the resemblance of the tumor rosettes to photoreceptors of the adult retina. In the 1920s, Verhoeff 22 believed that the tumor arose from embryonic retinal cells and proposed the name "retinoblastoma." The subject of histogenesis lay moot for decades until the late 1960s, when Ts'o and associates 23,24 studied the ultrastructural features of more differentiated tumors and found clear evidence of photoreceptor differentiation.…”