Retinoblastoma

Abstract

Although treatment outcomes for retinoblastoma have improved, patients with a germline gene mutation carry a high risk for second cancers. Background

Primary Malignant Tumours of Bone Following Previous Malignancy

“…It is becoming clearer that genetic factors play a major role in the aetiology of the second malignant neoplasm. These factors are already well established in patients with tumours such as retinoblastoma and Ewings sarcoma [4, 7]. In this study, we have reported six cases of breast carcinoma associated with chondrosarcoma.…”

“…It is well known that certain cancers are associated with an increased risk of a second cancer [3, 4], and that some treatments for cancer are in themselves known to be aetiological agents in the pathogenesis of a second cancer [5, 6] . It is commonly assumed that bone lesions occurring in patients who have already had a malignant neoplasm are metastases from that malignancy.…”

Primary Malignant Tumours of Bone Following Previous Malignancy

“…It is becoming clearer that genetic factors play a major role in the aetiology of the second malignant neoplasm. These factors are already well established in patients with tumours such as retinoblastoma and Ewings sarcoma [4, 7]. In this study, we have reported six cases of breast carcinoma associated with chondrosarcoma.…”

“…It is well known that certain cancers are associated with an increased risk of a second cancer [3, 4], and that some treatments for cancer are in themselves known to be aetiological agents in the pathogenesis of a second cancer [5, 6] . It is commonly assumed that bone lesions occurring in patients who have already had a malignant neoplasm are metastases from that malignancy.…”

RICS, a Novel GTPase-activating Protein for Cdc42 and Rac1, Is Involved in the β-Catenin-N-cadherin andN-Methyl-d-aspartate Receptor Signaling

“…Primary Neuron Culture and Immunostaining-Hippocampal primary neuronal cultures prepared from embryonic day 18 -19 rat embryos (78) were plated on coverslips coated with poly-L-lysine (50 g/ml) (5 ϫ 10 4 cells/well). Cultures were grown in Neurobasal medium (Invitrogen) supplemented with B27 (Invitrogen) and 0.5 mM glutamine.…”

Primary Malignant Tumours of Bone Following Previous Malignancy

“…It is becoming clearer that genetic factors play a major role in the aetiology of the second malignant neoplasm. These factors are already well established in patients with tumours such as retinoblastoma and Ewings sarcoma [4, 7]. In this study, we have reported six cases of breast carcinoma associated with chondrosarcoma.…”

“…It is well known that certain cancers are associated with an increased risk of a second cancer [3, 4], and that some treatments for cancer are in themselves known to be aetiological agents in the pathogenesis of a second cancer [5, 6] . It is commonly assumed that bone lesions occurring in patients who have already had a malignant neoplasm are metastases from that malignancy.…”

RICS, a Novel GTPase-activating Protein for Cdc42 and Rac1, Is Involved in the β-Catenin-N-cadherin andN-Methyl-d-aspartate Receptor Signaling

“…Primary Neuron Culture and Immunostaining-Hippocampal primary neuronal cultures prepared from embryonic day 18 -19 rat embryos (78) were plated on coverslips coated with poly-L-lysine (50 g/ml) (5 ϫ 10 4 cells/well). Cultures were grown in Neurobasal medium (Invitrogen) supplemented with B27 (Invitrogen) and 0.5 mM glutamine.…”

Primary Malignant Tumours of Bone Following Previous Malignancy

“…It is becoming clearer that genetic factors play a major role in the aetiology of the second malignant neoplasm. These factors are already well established in patients with tumours such as retinoblastoma and Ewings sarcoma [4, 7]. In this study, we have reported six cases of breast carcinoma associated with chondrosarcoma.…”

“…It is well known that certain cancers are associated with an increased risk of a second cancer [3, 4], and that some treatments for cancer are in themselves known to be aetiological agents in the pathogenesis of a second cancer [5, 6] . It is commonly assumed that bone lesions occurring in patients who have already had a malignant neoplasm are metastases from that malignancy.…”

RICS, a Novel GTPase-activating Protein for Cdc42 and Rac1, Is Involved in the β-Catenin-N-cadherin andN-Methyl-d-aspartate Receptor Signaling

“…Primary Neuron Culture and Immunostaining-Hippocampal primary neuronal cultures prepared from embryonic day 18 -19 rat embryos (78) were plated on coverslips coated with poly-L-lysine (50 g/ml) (5 ϫ 10 4 cells/well). Cultures were grown in Neurobasal medium (Invitrogen) supplemented with B27 (Invitrogen) and 0.5 mM glutamine.…”