Retinal thickness assessed by optical coherence tomography (OCT) in pseudophakic macular edema

Bonanomi, Maria Teresa Bc; Nicoletti, André Gustavo Bombana; Carricondo, Pedro Carlos; Buzalaf, Flávio; Kara‐José, Newton; Gomes, André Luís; Nakashima, Yoshitaka

doi:10.1590/s0004-27492006000400015

Cited by 14 publications

(7 citation statements)

References 17 publications

(34 reference statements)

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“…Grading of cataract was decided according to the estimated impact on visual acuity and by using slit lamp biomicroscopy. 8,9 The Feline Diabetes Message Board FAQ lists 60-120 mg/dL (3.3 -6.7 mmol/L) as "normalized" when not receiving insulin, and 60-150 mg/ dL (3.3-8.3) as "tightly regulated" when receiving insulin. Stratus OCT 3000 was used to measure both the foveal thickness and total macular volume.…”

Section: Materials and Methodologymentioning

confidence: 99%

Incidence of Clinical and Subclinical Cystoid Macular Edema in Diabetic and Non-Diabetic Patients After Cataract Surgery by Means of Optical Coherence Tomography

Deshpande¹

2018

DJO

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Purpose: To evaluate the incidence of clinical and subclinical cystoid macular edema in diabetic and non-diabetic patients after cataract surgery by means of Optical Coherence Tomography (OCT). Materials & Methods: A total of 30 eyes of 30 patients (15 diabetic and 15 non-diabetic) aged between 50 and 80 years diagnosed to have cataract were enrolled. Patients were investigated for absence of any evidence of macular edema with OCT before surgery. After undergoing cataract extraction by phacoemulsification with foldable IOL implant, OCT was again carried out at post operative 1st week and 4th week to know the foveal thickness and total macular volume. Similarly distance visual acuity was recorded at post-operative 1st and 4th week on Snellen's visual acuity chart. The comparison was done between visual acuity and OCT readings obtained in non-diabetic and diabetic patients to know the incidence of cystoid macular edema (CME). Results: There was no significant change found between foveal thickness measured pre-operatively and post-operatively at 1st and 4th week in diabetic and non-diabetic group but significant increase of total macular volume was found at post operative 4 weeks when compared with baseline in nondiabetic (p=<0.001) and diabetic group (p=0.035). There was a significant correlation found in foveal thickness and visual acuity in diabetic patients at 4th week of surgery. Conclusions: This study has shown a low incidence of subclinical CME. OCT showed increased macular volume in both groups of patients in a small percentage of cases.

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Section: Materials and Methodologymentioning

confidence: 99%

Incidence of Clinical and Subclinical Cystoid Macular Edema in Diabetic and Non-Diabetic Patients After Cataract Surgery by Means of Optical Coherence Tomography

Deshpande¹

2018

DJO

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“…Typically, in retinal implantation trials [24], the implant is placed closer to the fovea, but not over it [25] due to the absence of ganglion and bipolar cells in the fovea. The retinal thickness in the region surrounding the fovea is known to vary between ~100 μm at the foveal floor to ~320 μm at the foveal rim [26]. Considering that the location of the implant near the fovea is not precise, the chosen value for the retinal thickness was 200 μm.…”

Section: Methodsmentioning

confidence: 99%

Simulation of epiretinal prostheses - Evaluation of geometrical factors affecting stimulation thresholds

Kasi

Hasenkamp

Cosendai

et al. 2011

J NeuroEngineering Rehabil

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BackgroundAn accurate understanding of the electrical interaction between retinal prostheses and retinal tissue is important to design effective devices. Previous studies have used modelling approaches to simulate electric fields generated by epiretinal prostheses in saline and to simulate retinal ganglion cell (RGC) activation using passive or/and active biophysical models of the retina. These models have limited scope for studying an implanted human retinal prosthesis as they often do not account for real geometry and composition of the prosthesis-retina interface. This interface consists of real dimensions and location of stimulation and ground electrodes that are separated by the retinal tissue and surrounded by physiological fluids.MethodsIn this study, we combined the prosthesis-retina interface elements into a framework to evaluate the geometrical factors affecting stimulation thresholds for epiretinal prostheses used in clinical human trials, as described by Balthasar et al. in their Investigative Ophthalmology and Visual Science (IOVS) paper published in 2008 using the Argus I epiretinal implants. Finite element method (FEM) based computations were used to estimate threshold currents based on a threshold criterion employing a passive electric model of the retina.ResultsThreshold currents and impedances were estimated for different electrode-retina distances. The profiles and the values for thresholds and impedances obtained from our simulation framework are within the range of measured values in the only elaborate published clinical trial until now using Argus I epiretinal implants. An estimation of resolution for the electrodes used in these trials was provided. Our results reiterate the importance of close proximity between electrodes and retina for safe and efficient retinal stimulation.ConclusionsThe validation of our simulation framework being relevant for epiretinal prosthesis research is derived from the good agreement of the computed trends and values of the current study with measurements demonstrated in existing clinical trials on humans (Argus I). The proposed simulation framework could be used to generate the relationship between threshold and impedance for any electrode geometry and consequently be an effective tool for design engineers, surgeons and electrophysiologists.

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“…Clinical CME appears on average from 4 to 6 weeks after surgery. 24,25 . It is important to differentiate PCME from a possible subretinal neovascular membrane secondary to macular degeneration related to age.…”

Section: Diagnosis and Differential Diagnosis For Cmementioning

confidence: 99%

Cistoidni makularni edem nakon operacije katarakte

Merlak

Gržetić-Lenac

Babić

et al. 2019

Med. Flum. (Online)

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Pseudophakic cystoid macular edema (PCME) is the most common complication of cataract surgery and is one of the possible causes of low visual acuity after cataract surgery. Various factors are implicated in its development but the core mechanism is likely surgically induced anterior segment inflammation that results in the release of endogenous inflammatory mediators. Anti-inflammatory medicines, including steroid and nonsteroid anti-inflammatory drugs, are postulated as having a role in both the prophylaxis and treatment of PCME. This article presents an updated review on the pathogenesis, risk factors, prophylaxis and treatment in PCME that reflect current research and practice.Sažetak: Cistoidni makularni edem komplikacija je nakon operacije katarakte i najčešći je uzrok loše vidne oštrine nakon operacije katarakte. Različiti su patofiziološki mehanizmi nastanka makularnog edema, ali najčešće se dovodi u vezu s postoperativnom upalom pri kojoj se oslobađaju medijatori upale i dovode do nakupljanja tekućine u području makule. Protuupalni lijekovi, uključujući steroide i nesteroidne antireumatike, imaju veliku ulogu u profilaksi i terapiji cistoidnog makularnog edema. U ovom preglednom članku prikazani su najnoviji stavovi o patogenetskom mehanizmu nastanka edema, rizičnim faktorima, profilaksi i terapiji, proizišli iz istraživanja i kliničke prakse.

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Retinal thickness assessed by optical coherence tomography (OCT) in pseudophakic macular edema

Cited by 14 publications

References 17 publications

Incidence of Clinical and Subclinical Cystoid Macular Edema in Diabetic and Non-Diabetic Patients After Cataract Surgery by Means of Optical Coherence Tomography

Incidence of Clinical and Subclinical Cystoid Macular Edema in Diabetic and Non-Diabetic Patients After Cataract Surgery by Means of Optical Coherence Tomography

Simulation of epiretinal prostheses - Evaluation of geometrical factors affecting stimulation thresholds

Cistoidni makularni edem nakon operacije katarakte

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