Retinal Pigment Epithelial Window Defect

Precise correlation of histopathological and fluorescein angiographic morphology using retinal vascular casting

“…Thus, the most prominent finding of the study was that the transmission of choroidal background fluorescence correlated intimately with the presence of material excessively accumulated in the retina. In a prior clinicopathological study focal fluorescein angiographical hyperfluorescence has been demonstrated to correlate with lack of pigment granules in the pigment epithelium, producing a window defect (Keno & Green 1978). The present study adds to this evidence by also showing the reverse, i.e.…”

Precise correlation of histopathological and fluorescein angiographic morphology using retinal vascular casting

“…Thus, the most prominent finding of the study was that the transmission of choroidal background fluorescence correlated intimately with the presence of material excessively accumulated in the retina. In a prior clinicopathological study focal fluorescein angiographical hyperfluorescence has been demonstrated to correlate with lack of pigment granules in the pigment epithelium, producing a window defect (Keno & Green 1978). The present study adds to this evidence by also showing the reverse, i.e.…”

Correlation between clinical and histological features in a pig model of choroidal neovascularization

“…The correlation between histopathological features and the fluorescein angiographic appearances of choroidal neovascularization (CNV) has been studied both in post-mortem eyes [2,5,8] and in surgically excised choroidal neovascular membranes [1,4]. These studies have contributed significantly to our understanding of CNV.…”

Fluorescein Angiography Findings in Children With Congenital Zika Syndrome

“…Previous studies by Singh et al 19 and Zhao et al 20 have shown that the RPE is highly susceptible to the ZIKV in an animal model and in vivo experiments and suggested that the ZIKV damages the retina by disrupting the BRB. 19,20 In addition, the histopathological study by Fernandez et al 15 isolated the ZIKV in several ocular tissues, including the retina and choroid, and suggested that the ZIKV gains access to the fetal circulation, thus allowing access to the inner and outer BRB. By identifying window defects in the eyes of children with the CZS, the current study supports the notion that the ZIKV can disrupt the outer BRB.…”

“…One of the most common retinal abnormalities detected by FA and previously unidentified by fundus examination and wide-angle imaging were the window defects in the macular region that were seen in six eyes (50%); these defects also are seen in other diseases that affect the RPE, such as rubella retinitis, choroideremia, and thioridazine toxicity. 19 The histopathological analysis of human eyes showed that the window defects corresponded to areas in which the RPE cells were thin, fewer in number, had loss of pigment granules, and were associated with partial loss of the photoreceptors and choriocapillaris. According to Keno and Green, 19 the choriocapillaris changes occur first followed by RPE and photoreceptor cellular loss, which suggests damage to the BRB and consequently damage to the outer retinal layers.…”

“…19 The histopathological analysis of human eyes showed that the window defects corresponded to areas in which the RPE cells were thin, fewer in number, had loss of pigment granules, and were associated with partial loss of the photoreceptors and choriocapillaris. According to Keno and Green, 19 the choriocapillaris changes occur first followed by RPE and photoreceptor cellular loss, which suggests damage to the BRB and consequently damage to the outer retinal layers.…”

Precise correlation of histopathological and fluorescein angiographic morphology using retinal vascular casting

“…Thus, the most prominent finding of the study was that the transmission of choroidal background fluorescence correlated intimately with the presence of material excessively accumulated in the retina. In a prior clinicopathological study focal fluorescein angiographical hyperfluorescence has been demonstrated to correlate with lack of pigment granules in the pigment epithelium, producing a window defect (Keno & Green 1978). The present study adds to this evidence by also showing the reverse, i.e.…”

Correlation between clinical and histological features in a pig model of choroidal neovascularization

“…The correlation between histopathological features and the fluorescein angiographic appearances of choroidal neovascularization (CNV) has been studied both in post-mortem eyes [2,5,8] and in surgically excised choroidal neovascular membranes [1,4]. These studies have contributed significantly to our understanding of CNV.…”

Fluorescein Angiography Findings in Children With Congenital Zika Syndrome

“…Previous studies by Singh et al 19 and Zhao et al 20 have shown that the RPE is highly susceptible to the ZIKV in an animal model and in vivo experiments and suggested that the ZIKV damages the retina by disrupting the BRB. 19,20 In addition, the histopathological study by Fernandez et al 15 isolated the ZIKV in several ocular tissues, including the retina and choroid, and suggested that the ZIKV gains access to the fetal circulation, thus allowing access to the inner and outer BRB. By identifying window defects in the eyes of children with the CZS, the current study supports the notion that the ZIKV can disrupt the outer BRB.…”

“…One of the most common retinal abnormalities detected by FA and previously unidentified by fundus examination and wide-angle imaging were the window defects in the macular region that were seen in six eyes (50%); these defects also are seen in other diseases that affect the RPE, such as rubella retinitis, choroideremia, and thioridazine toxicity. 19 The histopathological analysis of human eyes showed that the window defects corresponded to areas in which the RPE cells were thin, fewer in number, had loss of pigment granules, and were associated with partial loss of the photoreceptors and choriocapillaris. According to Keno and Green, 19 the choriocapillaris changes occur first followed by RPE and photoreceptor cellular loss, which suggests damage to the BRB and consequently damage to the outer retinal layers.…”

“…19 The histopathological analysis of human eyes showed that the window defects corresponded to areas in which the RPE cells were thin, fewer in number, had loss of pigment granules, and were associated with partial loss of the photoreceptors and choriocapillaris. According to Keno and Green, 19 the choriocapillaris changes occur first followed by RPE and photoreceptor cellular loss, which suggests damage to the BRB and consequently damage to the outer retinal layers.…”

Precise correlation of histopathological and fluorescein angiographic morphology using retinal vascular casting

“…Thus, the most prominent finding of the study was that the transmission of choroidal background fluorescence correlated intimately with the presence of material excessively accumulated in the retina. In a prior clinicopathological study focal fluorescein angiographical hyperfluorescence has been demonstrated to correlate with lack of pigment granules in the pigment epithelium, producing a window defect (Keno & Green 1978). The present study adds to this evidence by also showing the reverse, i.e.…”

Correlation between clinical and histological features in a pig model of choroidal neovascularization

“…The correlation between histopathological features and the fluorescein angiographic appearances of choroidal neovascularization (CNV) has been studied both in post-mortem eyes [2,5,8] and in surgically excised choroidal neovascular membranes [1,4]. These studies have contributed significantly to our understanding of CNV.…”

Fluorescein Angiography Findings in Children With Congenital Zika Syndrome

“…Previous studies by Singh et al 19 and Zhao et al 20 have shown that the RPE is highly susceptible to the ZIKV in an animal model and in vivo experiments and suggested that the ZIKV damages the retina by disrupting the BRB. 19,20 In addition, the histopathological study by Fernandez et al 15 isolated the ZIKV in several ocular tissues, including the retina and choroid, and suggested that the ZIKV gains access to the fetal circulation, thus allowing access to the inner and outer BRB. By identifying window defects in the eyes of children with the CZS, the current study supports the notion that the ZIKV can disrupt the outer BRB.…”

“…One of the most common retinal abnormalities detected by FA and previously unidentified by fundus examination and wide-angle imaging were the window defects in the macular region that were seen in six eyes (50%); these defects also are seen in other diseases that affect the RPE, such as rubella retinitis, choroideremia, and thioridazine toxicity. 19 The histopathological analysis of human eyes showed that the window defects corresponded to areas in which the RPE cells were thin, fewer in number, had loss of pigment granules, and were associated with partial loss of the photoreceptors and choriocapillaris. According to Keno and Green, 19 the choriocapillaris changes occur first followed by RPE and photoreceptor cellular loss, which suggests damage to the BRB and consequently damage to the outer retinal layers.…”

“…19 The histopathological analysis of human eyes showed that the window defects corresponded to areas in which the RPE cells were thin, fewer in number, had loss of pigment granules, and were associated with partial loss of the photoreceptors and choriocapillaris. According to Keno and Green, 19 the choriocapillaris changes occur first followed by RPE and photoreceptor cellular loss, which suggests damage to the BRB and consequently damage to the outer retinal layers.…”