2009
DOI: 10.1167/iovs.08-2332
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Abstract: BRVO results in a rapid transient increase in the expression of VEGF and a delayed increase in the expression of PEDF. The downregulation of Kir4.1 and aquaporins, the mislocation of Kir4.1 protein, and the osmotic swelling of Müller cells may contribute to the development of edema and neuronal degeneration.

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Cited by 90 publications
(78 citation statements)
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“…These changes were probably brought about by hypoxia and decreased nitric oxide production, 39 apoptosis, 40 and general inflammation with alterations in retinal gene expression and Müller cell activity throughout the retina. 41 As expected with retinal ischemia, the inner retinal responses (iN1) were more severely depressed by the BRVO than outer retinal responses (P1).…”
Section: Consequences Of Gdnf Treatment In Brvo Eyessupporting
confidence: 52%
“…These changes were probably brought about by hypoxia and decreased nitric oxide production, 39 apoptosis, 40 and general inflammation with alterations in retinal gene expression and Müller cell activity throughout the retina. 41 As expected with retinal ischemia, the inner retinal responses (iN1) were more severely depressed by the BRVO than outer retinal responses (P1).…”
Section: Consequences Of Gdnf Treatment In Brvo Eyessupporting
confidence: 52%
“…Creating retinal occlusions has depended primarily upon the slit-lamp biomicroscope [3][4][5][6][7][8][9]. Our multimodal imaging system for producing retinal occlusions in animal models has several advantages over using a slit-lamp biomicroscope.…”
Section: Discussionmentioning
confidence: 99%
“…In the first technique, the fundus is visualized with a modified slit-lamp biomicroscope using a high-power laser delivery system (~100-200 mW) [3][4][5]. A skilled operator then manually delivers high energy laser shots to a target retinal vessel until vascular occlusion appears to have occurred.…”
Section: Introductionmentioning
confidence: 99%
“…Downregulation of carbonic anhydrase [14,15] and inwardly rectifying potassium (Kir) channels (fig. 1d, 2, 3a, b, d) [23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38] results in disturbances of retinal acid-base, ion and water homeostasis (see below) [7,39]. …”
Section: Müller Cell Gliosismentioning
confidence: 99%
“…Such alterations have been observed in animal models of various retinal diseases, including ischemia-reperfusion, inflammation, diabetic retinopathy, blue-light injury, detachment, vein occlusion and proliferative vitreoretinopathy, as well as in Müller cells from patients with proliferative retinopathies (fig. 5a) [17,18,19,20,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,199]. Ischemia causes a decrease in Kir4.1 (but not Kir2.1) expression (fig.…”
Section: Dysfunctional Retinal Potassium Homeostasismentioning
confidence: 99%