Retiform hemangioendothelioma: Another tumor associated with human herpesvirus type 8?

Schommer, Markus; Herbst, Rudolf; Brodersen, Jens P.; Kiehl, Peter; Katenkamp, D.; Kapp, Alexander; Weiß, Jürgen

doi:10.1016/s0190-9622(00)90143-9

Cited by 47 publications

(45 citation statements)

References 10 publications

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“…In their originally reported cases, RH was regarded as "low-grade angiosarcoma" because this tumor recurred frequently with low metastatic rate [2]. Since then, a few reports of similar cases were published, most often occurring on the extremities of young adults [3][4][5][6][7][8][9]. In 2002, World Health Organization (WHO) classification of tumors of soft tissue and bone accepted RH as a rare entity, and identified it as an intermediate vascular neoplasm with putative borderline malignancy, as opposed to the benign angioma and the malignant angiosarcoma [25].…”

Section: Discussionmentioning

confidence: 99%

“…The etiology of RH is still unknown. Several reports have proposed its association with lymphedema, previous radiation treatment, and non-epidermal malignant tumors [2,5,8]. An association between RH and human herpes virus 8 (HHV-8) has been reported in one case [8].…”

Section: Discussionmentioning

confidence: 99%

“…RH does not show a preference for a specific anatomic site, but most of tumors involve the dermis and subcutaneous tissues of extremities (especially lower limbs and fingers). Tumor has also been described in other deeper locations, including trunk [8], breast [4] and bone [10]. Clinically, RH can present as a plaque, nodule, or exophytic mass with duration of disease ranging from 2 months to several years.…”

Section: Discussionmentioning

confidence: 99%

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Unusual multiple cutaneous retiform hemangioendothelioma on forearm and neck misdiagnosed as angiosarcoma with metastasis

Pan¹,

Wang²,

Huang³

et al. 2017

Clin Diagn Pathol

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Retiform hemangioendothelioma (RH) is extremely rare, and often involves the skin and subcutaneous tissues of distal extremities in young adults or children. Since its first description by Calonje in 1994, only a few primary multiple cases have been described in the literature. We present a case of unusual primary multiple RH on forearm and neck occurring in a 56 years old female patient. The patient presented with a slow-growing cutaneous plaque-like lesion on her left forearm, followed by another lesion at the site of neck for several years. In the skin biopsy examination, a diagnosis of angiosarcoma with cutaneous metastasis was made based on multiple lesions at different anatomic sites and vasoformative growth pattern with anastomosing channels under the microscopy. However, postoperative histological diagnosis of the lesion was primary multiple RH by thoroughly microscopical inspection and the presence of thin-walled interconnecting vascular channels arranged in a retiform pattern and absence of lymph node metastasis. Despite wide surgical excision with tumor-free margin, the tumor recurred at the neck 3 months after surgery. The second local excision was performed. The patient was on regular follow-up for 18 months without additional treatments. There was no sign of recurrence or lymph node metastasis. Due to its rarity, multiple RH might be erroneously interpreted as angiosarcoma with metastasis by those who were not familiar with this condition, or conduce to aggressive postoperative treatment. Therefore, thoroughly microscopical inspection and a long-term follow-up are helpful for surgeons and pathologists to obtain an accurate diagnosis and avoid clinical over-treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Unusual multiple cutaneous retiform hemangioendothelioma on forearm and neck misdiagnosed as angiosarcoma with metastasis

Pan¹,

Wang²,

Huang³

et al. 2017

Clin Diagn Pathol

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“…The neoplasm was originally named in 1994 by Calonje et al [2], when they described 15 cases and highlighted their clinical course and characteristic histologic appearance, which is highly reminiscent of normal rete testis. Subsequently, a few other cases have been reported [5,6,7,8,10,12,13]. Although retiform hemangioendothelioma is locally aggressive and recurs frequently, the rate of metastasis is low [2,6].…”

Section: Discussionmentioning

confidence: 99%

“…The neoplasm has nonspecific clinical features [7]. It may appear as a slow-growing exophytic mass, a plaque-like lesion, or a dermal or subcutaneous nodule [2,5,6,7,8,10,12,13]. In only two cases previously reported was the diagnosis of a vascular tumor considered preoperatively [2].…”

Section: Discussionmentioning

confidence: 99%

Fast growing multifocal retiform hemangioendothelioma: a case report

Ulrich

Hrynyschyn²

2002

European Journal of Plastic Surgery

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Retiform hemangioendothelioma is a vascular tumor of intermediate malignancy. In general, it is a slow-growing single exophytic nodular or plaque-like lesion. We present a 17-year-old male patient with a rapidly growing multifocal retiform hemangioendothelioma on his right ulno-dorsal forearm. After first excision, within 4 weeks the tumor showed local recurrence. Treatment was made by wide excision with a 1-cm margin and fascia and closure of the defect by split-thickness skin graft. Two months later, a new lesion was observed on the back of the patient's hand. After excision and wound closure with split-thickness skin grafting, there was no recurrence in a 2-year follow-up period. We discuss diagnosis, prognosis, and possible surgical treatment of this rare skin neoplasm.

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