Reticulocyte hemoglobin content as a predictor of iron deficiency anemia

Abstract

Background Iron deficiency anemia (IDA) is the most common

Reticulocyte Hemoglobin Equivalent (Ret-He) sebagai Parameter Defisiensi Besi pada Bayi dan Anak

“…Salah satu pemeriksaan spesifik untuk menilai defisiensi besi yang direkomendasikan American Academy of Pediatrics (AAP) adalah reticulocyte hemoglobin equivalent (Ret-He) atau reticulocyte hemoglobin content (CHr). 13,20 Perbedaannya, CHr dianalisis dengan alat ADVIA 120 dan 2120, sedangkan Ret-He dianalisis dengan XE 2100, XE 5000 dan seri XN; keduanya menunjukkan korelasi yang baik. [21][22][23] Ketersediaan besi fungsional untuk dimasukkan ke dalam eritrosit dalam sumsum tulang selama eritropoiesis tercermin dari jumlah Hb dalam retikulosit, sehingga Ret-He menunjukkan kecukupan zat besi dalam sumsum tulang untuk eritropoiesis.…”

Reticulocyte hemoglobin equivalent as a diagnostic parameter of iron deficiency anemia in infants age 1-4 months

“…Some studies show that Ret-He is excellent for detecting iron deficiency [18,[24][25][26][27]]. Suari's study to detect IDA with a Ret-He cut-off value of 23.1 pg at the age of 6-60 months had a sensitivity of 88%, specificity of 25%, the positive predictive value of 34%, and a negative predictive value of 82% [14]. The Lorenz study to detect iron deficiency with a Ret-He cut-off value of 29 pg in corrected infants aged 3-4 months (<32 weeks and <1500 grams) had a sensitivity of 85%, specificity 73%, positive predictive value 33%, and a negative predictive value of 97% [21].…”

“…The diagnostic power of Ret-He for detecting iron deficiency without anemia is higher than serum ferritin and Hb (sensitivity 70-94%, specificity 72-80%) [17], and superior to ferritin or zinc protoporphyrin/heme ratio in neonates [31]. Several studies of Ret-He to detect iron deficiency in infants showed a sensitivity of 70-94%, specificity 72-80%, positive predictive value 33-34%, and negative predictive value 82-97% [14,17,21].…”

“…One of the iron deficiency parameters that are easy, inexpensive to apply, and recommended by the American Academy of Pediatrics (AAP) is Reticulocyte Hemoglobin Equivalent (Ret-He), which assesses the amount of hemoglobin in reticulocytes [12,14]. The Ret-He examination can detect iron deficiency before a decrease in hemoglobin (Hb) levels or anemia occurs.…”

“…Ret-He cut-off[23]. The cut-off value of Ret-He for IDA in infants aged 6-60 months is 23.1 pg[14]. The…”