Reticular premotor neurons projecting to both facial and hypoglossal nuclei receive trigeminal afferents in rats

Dauvergne, Céline; Pinganaud, Gabrielle; Buisseret, P; Buisseret-Delmas, C.; Zerari-Mailly, Fawzia

doi:10.1016/s0304-3940(01)02150-4

Cited by 36 publications

(20 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Neurons in the IRt/PCRt that project to the oromotor nuclei are rhythmically active during both cortically induced (electrical) stimulation (Inoue, Chandler, & Goldberg, 1994; Sahara, Hashimoto, & Nakamura, 1996) as well as intraoral stimulation in the awake, freely moving preparation (Travers, DiNardo, & Karimnamazi, 2000). In addition to the forebrain projections discussed above, neurons in the IRt/PCRt receive input from the (gustatory) rNST (Nasse et al , 2008) and parabrachial nucleus (Karimnamazi & Travers, 1998), as well as trigeminal somatosensory input (Dauvergne, Pinganaud, Buisseret, Buisseret-Delmas, & Zerari-Mailly, 2001; Zerari-Mailly, Pinganaud, Dauvergne, Buisseret, & Buisseret-Delmas, 2001). Thus, the IRt/PCRt may be an important integrative node for consummatory ingestive behavior that receives input from multiple descending forebrain as well as local orosensory sources.…”

Section: Discussionmentioning

confidence: 99%

Suppression of third ventricular NPY-elicited feeding following medullary reticular formation infusions of muscimol.

Travers

Herman²,

Travers³

2010

Behavioral Neuroscience

View full text Add to dashboard Cite

The appetitive component of feeding is controlled by forebrain substrates but the consummatory behaviors of licking, mastication and swallowing are organized in the brainstem. The target of forebrain appetitive signals is unclear but likely includes regions of the medullary reticular formation (RF). The present study was undertaken to determine the necessity of different RF regions for mastication induced by a descending appetitive signal. We measured solid food intake in response to third ventricular (3V) infusions of the orexigenic peptide, neuropeptide Y 3-36 in awake, freelymoving rats and determined whether focal RF infusions of the GABA A agonist muscimol suppressed eating. Reticular formation infusions were centered in either the lateral tegmental field, comprised of the intermediate (IRt) and parvocellular (PCRt) RF, or in the nucleus gigantocellularis (Gi). Infusions of NPY 3-36 (5 ug/5ul) into 3V significantly increased feeding of solid food over a 90 minute period compared to the non-infused condition (4.3 ± 0.56 versus 0.57 ± 0.57g, p < .001). NPY 3-36 induced food intake was suppressed (1.7g ± 0.48) by simultaneous infusions of muscimol (0.6 mM/100 nl) into the IRt/PCRt (p < .01). Coincident with the decrease in feeding was a decrease in the amplitude of anterior digastric muscle contractions in response to intra-oral sucrose infusions. In contrast, infusions of muscimol into Gi had no discernible effect on food intake or EMG amplitude. These data suggest that the IRt/PCRt is essential for forebrain-initiated mastication but that the Gi is not a necessary link in this pathway. Keywords mastication; central pattern generatorFeeding is controlled by structures located in widespread regions of the brain (Broberger, 2005) (Berthoud, 2002;Morton, Cummings, Baskin, Barsh, & Schwartz, 2006) (Saper, Chou, & Elmquist, 2002). Within this distributed system are certain critical nodes that subserve specific functions. One node, the hypothalamus, is sensitive to humoral and neural signals reflecting homeostatic state and receives numerous other inputs; e.g., from the nucleus accumbens, a forebrain structure implicated in reward (Kelley, Baldo, & Pratt, 2005). Many of the integrative capacities of the hypothalamus are shared by the caudal nucleus of the solitary tract in the medulla (Grill, 2006), but an animal reliant solely on the brainstem does not feed (Grill & Norgren, 1978a). For this reason, the appetitive component of feeding is thought to be organized in the forebrain. Critically, however, the forebrain structures that monitor energy balance, generate craving, and sense the rewarding properties of food must at some point interface with substrates that actually produce the behavior of eating. Compared to the remarkable progress in unraveling the intricate circuitry of the hypothalamus, relatively little is known of these pathways. It is generally accepted that the lower brainstem contains the neural circuitry responsible for the generation of consummatory behavior but the precise locations of the...

show abstract

Section: Discussionmentioning

confidence: 99%

Suppression of third ventricular NPY-elicited feeding following medullary reticular formation infusions of muscimol.

Travers

Herman²,

Travers³

2010

Behavioral Neuroscience

View full text Add to dashboard Cite

show abstract

“…4) Injections in both the STC and the VII (two animals): In the same animal BDA (3,000 MW) and gold-HRP were respectively injected in the STC and in the VII of the same side (cases D-G6 and D-G9). These experiments (ZerariMailly et al, 2001) were examined to find whether some solitarii-facial neurons receive trigeminal projections. The retrogradely gold-HRP-labeled neurons in contact with anterogradely BDA-labeled trigeminal boutons were systematically searched for in the entire NTS.…”

Section: Methodsmentioning

confidence: 99%

“…The STC is the main relay of facial sensory information conveyed through the primary afferent fibers of the trigeminal nerve (Nord, 1967;Panneton and Burton, 1981;Jacquin et al, 1983;Shigenaga et al, 1986a-c;Waite and Tracey, 1995), whereas the VII is one of the brainstem motor nuclei involved in facial movements (Courville, 1966;Martin and Lodge, 1977;Watson et al, 1982;Tsai et al, 1993;Faulkner et al, 1997). It is well documented that the sensory trigeminal information from the STC to the VII is conveyed through direct (Erzurumlu and Killackey, 1979;Takeuchi et al, 1979;Hinrichsen and Watson, 1983;Panneton and Martin, 1983;Travers and Norgren, 1983;Holstege et al, 1986;Yoshida et al, 1994;Pellegrini et al, 1995;Van Ham and Yeo, 1996;Pinganaud et al, 1999;Dauvergne et al, 2002) as well as indirect pathways (Holstege et al, 1977;Mizuno et al, 1978;Appenteng et al, 1989;Yamamoto et al, 1989;Castillo et al, 1991;Ter Horst et al, 1991;Dauvergne et al, 2001;Zerari-Mailly et al, 2001).…”

mentioning

confidence: 99%

Trigemino-solitarii-facial pathway in rats

Zerari-Mailly¹,

Buisseret²,

Buisseret-Delmas³

et al. 2005

J. Comp. Neurol.

Self Cite

View full text Add to dashboard Cite

This study was undertaken to identify premotor neurons in the nucleus tractus solitarii (NTS) serving as relay neurons between the sensory trigeminal complex (STC) and the facial motor nucleus in rats. Trigemino-solitarii connections were first investigated following injections of anterograde and/or retrograde (biotinylated dextran amine, biocytin, or gold-HRP) tracers in STC or NTS. Trigemino-solitarii neurons were abundant in the ventral and dorsal parts of the STC and of moderate density in its intermediate part. They project throughout the entire rostrocaudal extent of the NTS with a strong lateral preponderance. Solitarii-trigeminal neurons were observed mostly in the rostral and rostrolateral NTS. They mainly project to the ventral and dorsal parts of the spinal trigeminal nucleus but not to the principal nucleus. Additional neurons located in the middle NTS were found to project exclusively to the spinal trigeminal nucleus pars caudalis. No solitarii-trigeminal cells were observed in the caudal NTS. In addition, evidence was obtained of NTS retrogradely labeled neurons contacted by anterogradely labeled trigeminal terminals. Second, solitarii-facial projections were analyzed following injections of anterograde and retrograde tracers into the NTS and the facial nucleus, respectively. NTS neurons, except those of the rostrolateral part, reached the dorsal aspect of the facial nucleus. Finally, simultaneous injections of anterograde tracer in the STC and retrograde tracer in the facial nucleus gave retrogradely labeled neurons in the NTS receiving contacts from anterogradely labeled trigeminal boutons. Thus, the present data demonstrate for the first time the existence of a trigemino-solitarii-facial pathway. This could account for the involvement of the NTS in the control of orofacial motor behaviors.

show abstract

“…Apart from a role in pain transmission, RF is also involved in “normal” whisker movements. RF neurons receiving trigeminal input project to the lateral facial and hypoglossal nuclei (Dauvergne et al, 2001). In addition, RF receives direct input from wM1, and RF stimulation causes whisker retraction (Matyas et al, 2010).…”

Section: Whisker Motor Controlmentioning

confidence: 99%

Anatomical Pathways Involved in Generating and Sensing Rhythmic Whisker Movements

Bosman¹,

Houweling²,

Owens³

et al. 2011

Front. Integr. Neurosci.

211

225

View full text Add to dashboard Cite

The rodent whisker system is widely used as a model system for investigating sensorimotor integration, neural mechanisms of complex cognitive tasks, neural development, and robotics. The whisker pathways to the barrel cortex have received considerable attention. However, many subcortical structures are paramount to the whisker system. They contribute to important processes, like filtering out salient features, integration with other senses, and adaptation of the whisker system to the general behavioral state of the animal. We present here an overview of the brain regions and their connections involved in the whisker system. We do not only describe the anatomy and functional roles of the cerebral cortex, but also those of subcortical structures like the striatum, superior colliculus, cerebellum, pontomedullary reticular formation, zona incerta, and anterior pretectal nucleus as well as those of level setting systems like the cholinergic, histaminergic, serotonergic, and noradrenergic pathways. We conclude by discussing how these brain regions may affect each other and how they together may control the precise timing of whisker movements and coordinate whisker perception.

show abstract

Reticular premotor neurons projecting to both facial and hypoglossal nuclei receive trigeminal afferents in rats

Cited by 36 publications

References 16 publications

Suppression of third ventricular NPY-elicited feeding following medullary reticular formation infusions of muscimol.

Suppression of third ventricular NPY-elicited feeding following medullary reticular formation infusions of muscimol.

Trigemino-solitarii-facial pathway in rats

Anatomical Pathways Involved in Generating and Sensing Rhythmic Whisker Movements

Contact Info

Product

Resources

About