2016
DOI: 10.18632/aging.100942
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Abstract: Previous studies have shown positive effects of long-term resveratrol (RSV) supplementation in preventing pancreatic beta cell dysfunction, arterial stiffening and metabolic decline induced by high-fat/high-sugar (HFS) diet in nonhuman primates. Here, the analysis was extended to examine whether RSV may reduce dietary stress toxicity in the cerebral cortex of the same cohort of treated animals. Middle-aged male rhesus monkeys were fed for 2 years with HFS alone or combined with RSV, after which whole-genome mi… Show more

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Cited by 42 publications
(38 citation statements)
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References 78 publications
(85 reference statements)
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“…In addition, SIRT1 activation with resveratrol has been linked to protection against oxidative stress, metabolic decline and inflammation, while conferring cardiovascular and neural protection against nutrient stressors in rodents and non-human primates [13]. Furthermore, SIRT1 is shown to attenuate AD pathogenesis, synaptic plasticity, and learning and memory [14,15], and a reduction in SIRT1 activity in neurons is suggested as an early prognostic marker for AD [16,17].…”
Section: Introductionmentioning
confidence: 99%
“…In addition, SIRT1 activation with resveratrol has been linked to protection against oxidative stress, metabolic decline and inflammation, while conferring cardiovascular and neural protection against nutrient stressors in rodents and non-human primates [13]. Furthermore, SIRT1 is shown to attenuate AD pathogenesis, synaptic plasticity, and learning and memory [14,15], and a reduction in SIRT1 activity in neurons is suggested as an early prognostic marker for AD [16,17].…”
Section: Introductionmentioning
confidence: 99%
“…This is partly due to the up-regulation of PGC1α, which is a master regulator of mitochondrial respiration and contributes to mitochondrial biogenesis and detoxification (Liang and Ward, 2006). Furthermore, the upregulation of PGC1α modulates the expression of Nitric Oxide (NO) which has antioxidant and protective properties in the endothelium and may contribute to the preservation of brain microvasculature (Borniquel et al, 2006; Bernier et al 2016). Additionally, PGC1α is critical for the maintenance of dendritic spines in the dentate gyrus of the hippocampus, highlighting its importance in memory functions (Cheng et al, 2012).…”
Section: Unraveling the Relationships Among Calorie Restriction Lmentioning
confidence: 99%
“…Overexpression of SIRT1 (Kim et al, 2007; Lalla and Donmez, 2013) and activation of SIRT1 with resveratrol (Porquet et al, 2013; Porquet et al, 2014) can prevent or ameliorate cognitive impairment in experimental models of AD and age-related dementia. Moreover, it was shown that two-year resveratrol supplementation ameliorated neuroinflammation and increased cerebral microvasculature density in Rhesus macaques on a high fat diet (Bernier et al 2016). …”
Section: Anti-aging Compounds the Aging Brain And Dementiamentioning
confidence: 99%
“…Resveratrol treatment also counteracted high fat diet-induced fiber type switching from type I to II fibers in the soleus muscle 69 . In terms of the central nervous system, resveratrol conferred neuroprotection against diet-induced neuroinflammation and cerebral vascular dysfunction 70 . Together these studies are strongly supportive of a beneficial impact of resveratrol on health in over-nourished primates, boding well for its application in humans as preliminary studies suggest 71 .…”
Section: Resveratrolmentioning
confidence: 99%