Resveratrol prolongs lifespan and improves 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative damage and behavioural deficits in Drosophila melanogaster

Abolaji, Amos O.; Adedara, Adeola Oluwatosin; Adie, Mojisola A.; Vicente-Crespo, Marta

doi:10.1016/j.bbrc.2018.06.114

Cited by 89 publications

(61 citation statements)

References 40 publications

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“…It also prevents striatal dopamine loss and TH loss, both of which are typically seen in the dopamine neurons of PD patients [ 87 ]. Outside of rodent research, resveratrol increases survival rate and longevity and improves MPTP-induced acetylcholine inhibition and decreases H 2 O 2 and NO elevations in D. melanogaster flies [ 123 ]. Resveratrol has been suggested to show synergistic effects when given as treatment with flavonoids, as both polyphenols have differing cellular structures and thus could work in different cell compartments.…”

Section: Mechanisms Of Neuroprotectionmentioning

confidence: 99%

The Pathology of Parkinson’s Disease and Potential Benefit of Dietary Polyphenols

et al. 2020

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Parkinson’s disease (PD) is a progressive neurodegenerative disorder that is characterized by a loss of dopaminergic neurons, leading to bradykinesia, rigidity, tremor at rest, and postural instability, as well as non-motor symptoms such as olfactory impairment, pain, autonomic dysfunction, impaired sleep, fatigue, and behavioral changes. The pathogenesis of PD is believed to involve oxidative stress, disruption to mitochondria, alterations to the protein α-synuclein, and neuroinflammatory processes. There is currently no cure for the disease. Polyphenols are secondary metabolites of plants, which have shown benefit in several experimental models of PD. Intake of polyphenols through diet is also associated with lower PD risk in humans. In this review, we provide an overview of the pathology of PD and the data supporting the potential neuroprotective capacity of increased polyphenols in the diet. Evidence suggests that the intake of dietary polyphenols may inhibit neurodegeneration and the progression of PD. Polyphenols appear to have a positive effect on the gut microbiome, which may decrease inflammation that contributes to the disease. Therefore, a diet rich in polyphenols may decrease the symptoms and increase quality of life in PD patients.

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Section: Mechanisms Of Neuroprotectionmentioning

confidence: 99%

The Pathology of Parkinson’s Disease and Potential Benefit of Dietary Polyphenols

et al. 2020

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“…Resveratrol (RES), a non-flavonoid polyphenol extracted from a wide variety of plants, may exert neuroprotective effects on the treatment of PD [8] . Many studies have determined that RES can protect against neurotoxic destruction of dopaminergic neurons in response to 6-hydroxydopamine or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), owing to its ability to disrupt the degeneration of tyrosine hydroxylase positive (TH + ) dopaminergic neurons [9] , [10] . This activity is thought to be mediated via an Akt/Gsk-3β signaling pathway, ultimately leading to a reduction in rates of cell death in PD model systems [11] .…”

Section: Introductionmentioning

confidence: 99%

Enhancement of oral bioavailability and anti-Parkinsonian efficacy of resveratrol through a nanocrystal formulation

Xiong

Liu

Zhou

et al. 2020

Asian Journal of Pharmaceutical Sciences

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Resveratrol (RES), a non-flavonoid polyphenol extracted from a wide variety of plants, exhibits neuroprotective activities against Parkinson's disease (PD). However, undesirable water solubility of RES reduces its oral bioavailability and demonstrates low efficacy in blood and brain, thus limiting its application. In present study, a nanocrystal formulation of RES (RES-NCs) was developed to enhance its oral bioavailability and delivery into brain for PD treatment. RES-NCs were fabricated with hydroxypropyl methylcellulose (HPMC) stabilizer via antisolvent precipitation approach. The obtained RES-NCs displayed the particle size of 222.54 ± 1.66 nm, the PDI of 0.125 ± 0.035, the zeta potential of −9.41 ± 0.37 mV, and a rapid in vitro dissolution rate. Molecular dynamics simulation of RES and HPMC revealed an interaction energy of −68.09 kJ/mol and a binding energy of −30.98 ± 0.388 kJ/mol, indicating that the spontaneous binding between the two molecules is through van der Waals forces. RES-NCs conferred enhanced cellular uptake as well as improved permeability relative to pure RES. In addition, RES-NCs were able to protect neurons against cytotoxicity induced by MPP + . Meanwhile, RES-NCs exerted no significant toxic effects on zebrafish embryos and larvae, and did not influence their survival and hatching rates. When orally administered to rats, RES-NCs exhibited more favorable pharmacokinetics than pure RES, with higher plasma and brain concentrations. More importantly, MPTP-induced PD mice showed notable improvements in behavior, attenuated dopamine deficiency, and elevated levels of dopamine and its metabolites after the treatment with RES-NCs. Furthermore, immunoblot analysis revealed that the neuroprotective role of RES-NCs may be at least partially mediated by Akt/Gsk3β signaling pathway. Taken altogether, RES-NCs can serve as a potential treatment modality for PD, offering means of improving RES oral bioavailability and brain accumulation.

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“…Furthermore, several studies have associated the neuroprotective effects of RV with its antioxidant properties. In this context, studies have shown that RV decreases ROS production and/or increases antioxidant defenses after the exposure to MPTP/MPP + (Okawara et al, 2007;Lu et al, 2008;Anandhan et al, 2010;da Rocha Lindner et al, 2015;Abolaji et al, 2018) and rotenone (Gaballah et al, 2016;Lin et al, 2018;Palle and Neerati, 2018). These results are supported by other studies showing that RV protects against mitochondrial dysfunction induced by experimental PD, counteracting the changes in mitochondrial morphology and mitochondrial membrane potential (∆Ψm; Zeng et al, 2017;Lin et al, 2018), as well as increasing mitochondrial biogenesis (Peng et al, 2016) and complex-I activity (Palle and Neerati, 2018).…”

Section: Neuroprotective Effects Of Resveratrol In Parkinson's Diseasementioning

confidence: 62%

Resveratrol Derivatives as Potential Treatments for Alzheimer’s and Parkinson’s Disease

Arbo

André‐Miral

Nasre-Nasser

et al. 2020

Front. Aging Neurosci.

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Neurodegenerative diseases are characterized by the progressive loss of neurons in different regions of the nervous system. Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most prevalent neurodegenerative diseases, and the symptoms associated with these pathologies are closely related to the regions that are most affected by the process of neurodegeneration. Despite their high prevalence, currently, there is no cure or disease-modifying drugs for the treatment of these conditions. In the last decades, due to the need for the development of new treatments for neurodegenerative diseases, several authors have investigated the neuroprotective actions of naturally occurring molecules, such as resveratrol. Resveratrol is a stilbene found in several plants, including grapes, blueberries, raspberries, and peanuts. Studies have shown that resveratrol presents neuroprotective actions in experimental models of AD and PD, however, its clinical application is limited due to its rapid metabolism and low bioavailability. In this context, studies have proposed that structural changes in the resveratrol molecule, including glycosylation, alkylation, halogenation, hydroxylation, methylation, and prenylation could lead to the development of derivatives with enhanced bioavailability and pharmacological activity. Therefore, this review article aims to discuss how resveratrol derivatives could represent viable molecules in the search for new drugs for the treatment of AD and PD.

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Resveratrol prolongs lifespan and improves 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative damage and behavioural deficits in Drosophila melanogaster

Cited by 89 publications

References 40 publications

The Pathology of Parkinson’s Disease and Potential Benefit of Dietary Polyphenols

The Pathology of Parkinson’s Disease and Potential Benefit of Dietary Polyphenols

Enhancement of oral bioavailability and anti-Parkinsonian efficacy of resveratrol through a nanocrystal formulation

Resveratrol Derivatives as Potential Treatments for Alzheimer’s and Parkinson’s Disease

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