volume 10, issue 7, P1586-1596 2018
DOI: 10.18632/aging.101494
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Qiu-Xia Liang, Yi-Hua Lin, Chun-Hui Zhang, Hong-Mei Sun, Liang Zhou, Heide Schatten, Qing-Yuan Sun, Wei-Ping Qian

Abstract: After ovulation, metaphase II oocytes undergo a time-dependent deterioration in vivo or in vitro, which is referred to as postovulatory oocyte aging, a process during which a series of deleterious molecular and cellular changes occur. In this study, we found that short-term injection of resveratrol (3,5,4'-trihydroxystilbene) effectively ameliorated oxidative stress-induced damage in postovulatory oocyte aging of middle-aged mice in vivo. Resveratrol induced changes that delayed the aging-induced oocyte deteri…

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