Resveratrol Improves the Mitochondrial Function and Fertilization Outcome of          Bovine Oocytes

Takeo, Shun; Sato, Daichi; Kimura, Koji; Monji, Yasunori; Kuwayama, Takehito; Kawahara-Miki, Ryouka; Iwata, Hisataka

doi:10.1262/jrd.2013-102

Cited by 80 publications

(71 citation statements)

References 39 publications

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“…Resveratrol, a natural antioxidant, can enhance oocyte quality in diverse mammalian species (Lee, et al, 2010, Liu, et al, 2013, Mukherjee, et al, 2014). In bovine and porcine oocytes, resveratrol activates Sirtuin 1, which in turn promotes mitophagy to eliminate damaged mitochondria, increases mitochondrial number, and improves mitochondrial function (Sato, et al, 2014b, Takeo, et al, 2014). Resveratrol also enhances cumulus cell function, oocyte maturation, decreases ROS in bovine oocytes, and increases glutathione concentration in oocytes (Wang, et al, 2014).…”

Section: Interventions To Reduce Impact Of Er Stress Responsementioning

confidence: 99%

Stress signaling in mammalian oocytes and embryos: a basis for intervention and improvement of outcomes

Latham

2015

Cell Tissue Res

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Oocytes and early stage embryos are highly sensitive to variation in diverse exogenous factors such as temperature, osmolarity, oxygen, nutrient restriction, pH, shear stress, toxins, amino acid availability, and lipids. It is becoming increasingly apparent that many such factors negatively affect the endoplasmic reticulum, protein synthesis and protein processing, initiating ER stress and unfolded protein responses. As a result, ER stress signaling serves as a common mediator of cellular responses to diverse stressors. In oocytes and embryos, this leads to developmental arrest and epigenetic changes. Recent studies have revealed that preventing ER stress or inhibiting ER stress signaling can preserve or even enhance oocyte and embryo developmental potential. This chapter reviews ER stress signaling, how it arises, how it affects oocytes and embryos, and how its occurrence can be managed or prevented.

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Section: Interventions To Reduce Impact Of Er Stress Responsementioning

confidence: 99%

Stress signaling in mammalian oocytes and embryos: a basis for intervention and improvement of outcomes

Latham

2015

Cell Tissue Res

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“…Also examined was whether potassium bromate-induced mitochondrial aggregation could be rescued by the addition of the antioxidant, resveratrol, which has been suggested to be useful in IVM and embryo culture systems. Several studies have reported improvements with resveratrol: the fertilization rate was increased by a reduction of active oxygen, 28 the pregnancy rate was increased by improved mitochondrial function, 21 and fertility and embryo developmental capacities were improved by an increased number of active mitochondria, leading to better-quality oocytes. 29 Collectively, these reports suggest that resveratrol improves mitochondrial function.…”

Section: Discussionmentioning

confidence: 99%

“…It was revealed that high doses of potassium bromate decreased the percentage of oocytes at the metaphase II (MII) stage and increased abnormal mitochondrial distribution. Furthermore, as the efficacy of resveratrol as an antioxidant has been reported, it was investigated whether resveratrol could improve the oxidizing actions that had been elicited by potassium bromate.…”

Section: Introductionmentioning

confidence: 99%

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Potassium bromate disrupts mitochondrial distribution within murine oocytes during in vitro maturation

Yamada

Hiradate

Goto

et al. 2018

Reprod Medicine & Biology

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PurposeAs disturbed mitochondrial distribution is thought to be a cause of the aging of oocytes, it was investigated whether oxidizing agents exert harmful effects on nuclear maturation and mitochondrial cluster formation in murine oocytes and whether antioxidants could rescue such harmful effects in vitro.MethodsOocytes were obtained from female Institute of Cancer Research mice 48 h after an intraperitoneal injection of 7.5 IU pregnant mare serum gonadotropin. The oocytes were cultured with potassium bromate, an oxidizing agent, in the presence or absence of the antioxidant, resveratrol. After 12 h, the nuclear phases and mitochondrial distribution were observed.ResultsSignificantly decreased rates of metaphase II (MII) oocytes were observed with 750 μM and 1000 μM of potassium bromate, while a significant increase in abnormal mitochondrial clusters was induced at 500 μM, 750 μM, and 1,000 μM. The addition of 10 μM or 20 μM resveratrol improved both MII maturity and the cluster formation rates in the presence of potassium bromate.ConclusionsThe addition of potassium bromate reduced MII maturity rates and induced abnormal mitochondrial cluster formation. This effect was alleviated by the antioxidant, resveratrol. The in vitro model used herein is useful for investigating the functions of antioxidants in the aging of oocytes.

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“…Antioxidants can improve oocyte quality and enhance embryo development (Huang et al, 2013; Ideta et al, 2012; Orsi and Leese, 2001; Takeo et al, 2014; Wang et al, 2014a) and also protect against peroxide-induced damage (Yu et al, 2014) and other stress induced damage (Cebrian-Serrano et al ., 2013; Koyama et al ., 2012; Sakatani et al ., 2007) in embryos and oocytes (Devine et al ., 2012). Additionally, reduced glucose availability in vitro has long been recognized as beneficial to embryos (Chatot et al, 1989; Leese, 2012), although glucose starvation can actually increase ROS production and is not beneficial (Jansen et al, 2009).…”

Section: Activation and Inhibition Of Er Stress In Oocytes And Embmentioning

confidence: 99%

Endoplasmic Reticulum Stress Signaling in Mammalian Oocytes and Embryos: Life in Balance

Latham

2015

International Review of Cell and Molecular Biology

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Mammalian oocytes and embryos are exquisitely sensitive to a wide range of insults related to physical stress, chemical exposure, and exposures to adverse maternal nutrition or health status. Although cells manifest specific responses to various stressors, many of these stressors intersect at the endoplasmic reticulum, where disruptions in protein folding and production of reactive oxygen species initiate downstream signaling events. These signals modulate mRNA translation and gene transcription, leading to recovery, activation of autophagy, or with severe and prolonged stress, apoptosis. ER stress signaling has recently come to the fore as a major contributor to embryo demise. Accordingly, agents that modulate or inhibit ER stress signaling have yielded beneficial effects on embryo survival and long-term developmental potential. We review here the mechanisms of ER stress signaling, their connections to mammalian oocytes and embryos, and the promising indications that interventions in this pathway may provide new opportunities for improving mammalian reproduction and health.

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Resveratrol Improves the Mitochondrial Function and Fertilization Outcome of Bovine Oocytes

Cited by 80 publications

References 39 publications

Stress signaling in mammalian oocytes and embryos: a basis for intervention and improvement of outcomes

Stress signaling in mammalian oocytes and embryos: a basis for intervention and improvement of outcomes

Potassium bromate disrupts mitochondrial distribution within murine oocytes during in vitro maturation

Endoplasmic Reticulum Stress Signaling in Mammalian Oocytes and Embryos: Life in Balance

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