Resveratrol counteracts lipopolysaccharide-induced depressive-like behaviors<i>via</i>enhanced hippocampal neurogenesis

Liu, Liang; Qin, Zhang; Cai, Yulong; Sun, Dan; Xie, He; Wang, Lian; Yu, Dan; Li, Xin; Xiong, Xiao‐Yi; Xu, Haiwei; Yang, Qingwu; Fan, Xiaotang

doi:10.18632/oncotarget.11178

Cited by 93 publications

(64 citation statements)

References 58 publications

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“…Neuroinflammation has been proved to play an important role in depression. As previous studies suggested, related signaling pathway of inflammation has been proved to be highly associated with depression disease (29,30). Thus, we further explored the molecular link between inflammation and depression.…”

Section: Discussionmentioning

confidence: 85%

Retracted: Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced mice via RIP140/NF-κB pathway

Kong

Long

et al. 2016

IUBMB Life

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Section: Discussionmentioning

confidence: 85%

Retracted: Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced mice via RIP140/NF-κB pathway

Kong

Long

et al. 2016

IUBMB Life

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“…Further evidence suggest that it is the dorsal hippocampus that is involved in spatial learning and memory, while the ventral hippocampus is more associated with limbic functions (Brooker, Gobeske, Chen, Peng, & Kessler, ; Hyer, Hunter, Katakam, Wolz, & Glasper, ; Kheirbek & Hen, ; Loxton & Canales, ; McHugh, Fillenz, Lowry, Rawlins, & Bannerman, ; Schoenfeld, McCausland, Sonti, & Cameron, ). Abnormalities in hippocampal function are associated with various neurological and psychiatric disorders in adults such as anxiety, schizophrenia and depression (Ampuero, Jury, Hartel, Marzolo, & Zundert, ; Brooker et al, ; Caruncho et al, ; Danzer, Kotloski, Walter, Hughes, & McNamara, ; Liu et al, ; Perez‐Domper et al, ; Yun et al, ).…”

Section: Locations Of Adult Neural Stem Cells In the Mammalian Brainmentioning

confidence: 99%

“…For example, the dorsal hippocampus appears to be involved in spatial learning and memory, while the ventral hippocampus is associated with stress, emotion and affect (Brooker et al, ; Hyer et al, ; Kheirbek & Hen, ; Loxton & Canales, ; McHugh et al, ; Schoenfeld et al, ). The hippocampus appears to have important functions in neurological and psychiatric disorders including anxiety, schizophrenia and depression (Ampuero et al, ; Brooker et al, ; Caruncho et al, ; Danzer et al, ; Liu et al, ; Perez‐Domper et al, ; Yun et al, ). Lesions in the ventral hippocampus and specifically ventral dentate gyrus lesions in rodents produce decreased anxiety‐like behaviour (Cameron & Glover, ).…”

Section: Functional Aspects Of New Dgcs In the Adult Hippocampusmentioning

confidence: 99%

Adult neurogenesis in the mammalian dentate gyrus

Abbott

Nigussie

2019

Anat Histol Embryol

122

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Earlier observations in neuroscience suggested that no new neurons form in the mature central nervous system. Evidence now indicates that new neurons do form in the adult mammalian brain. Two regions of the mature mammalian brain generate new neurons: (a) the border of the lateral ventricles of the brain (subventricular zone) and (b) the subgranular zone (SGZ) of the dentate gyrus of the hippocampus. This review focuses only on new neuron formation in the dentate gyrus of the hippocampus. During normal prenatal and early postnatal development, neural stem cells (NSCs) give rise to differentiated neurons. NSCs persist in the dentate gyrus SGZ, undergoing cell division, with some daughter cells differentiating into functional neurons that participate in learning and memory and general cognition through integration into pre‐existing neural networks. Axons, which emanate from neurons in the entorhinal cortex, synapse with dendrites of the granule cells (small neurons) of the dentate gyrus. Axons from granule cells synapse with pyramidal cells in the hippocampal CA3 region, which send axons to synapse with CA1 hippocampal pyramidal cells that send their axons out of the hippocampus proper. Adult neurogenesis includes proliferation, differentiation, migration, the death of some newly formed cells and final integration of surviving cells into neural networks. We summarise these processes in adult mammalian hippocampal neurogenesis and discuss the roles of major signalling molecules that influence neurogenesis, including neurotransmitters and some hormones. The recent controversy raised concerning whether or not adult neurogenesis occurs in humans also is discussed.

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“…The TST was performed according to previously reported methods. 24,25 Mice were suspended by a mounted hook 50 cm above the floor using adhesive tape, which was placed ~1 cm from the tip of the tail. The activities of mice were recorded for 6 min.…”

Section: Tail Suspension Test (Tst)mentioning

confidence: 99%

Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life

Gao

Gong

et al. 2018

IJN

Self Cite

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IntroductionSilica nanoparticles (SiO2-NPs) are currently among the most widely used nanomaterials, but their potentially adverse effects on brain development remain unknown. The developing brain is extremely sensitive to NP neurotoxicity during the early postnatal period.Materials and methodsHerein, we investigated the effects of SiO2-NPs (doses of 10, 20, or 50 mg with a particle size of ~91 nm, equivalent to aerosol mass concentrations 55.56, 111.11, and 277.78 mg/m3, respectively) exposure from postnatal day (P) 1 to P7 on hippocampal precursor proliferation at P8 and long-term neurobehavior in adults.ResultsSiO2-NP exposure resulted in inflammatory cell infiltration in lung tissue, microglia over-activation in the hippocampal dentate gyrus (DG), and decreased hippocampal precursor proliferation in the DG-subgranular zone at P8. Moreover, after exposure to 20 mg of SiO2-NPs, mice exhibited social interaction deficits and slight anxiety-like behaviors in adulthood, but this exposure did not induce locomotor activity impairment, depression-like behavior, or short-term memory impairment.DiscussionThese findings suggest that early-age SiO2-NP exposure induced inflammation and inhibited precursor proliferation in the DG in a dose-dependent manner, which might be related to the social dysfunction observed in adulthood.

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Resveratrol counteracts lipopolysaccharide-induced depressive-like behaviorsviaenhanced hippocampal neurogenesis

Abstract: Radial glial-like cells (RGLs) in the adult dentate gyrus (DG) function as progenitor cells for adult hippocampal neurogenesis, a process involved in the stress-related pathophysiology and treatment efficiency of depression. Resveratrol

Cited by 93 publications

References 58 publications

Retracted: Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced mice via RIP140/NF-κB pathway

Retracted: Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced mice via RIP140/NF-κB pathway

Adult neurogenesis in the mammalian dentate gyrus

Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life

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