Resveratrol: beneficial or not? Opposite effects of resveratrol on hypoxia-dependent PAI-1 expression in tumour and primary cells

Ganjam, Goutham K.; Franklin, Tabughang; Kietzmann, Thomas; Dimova, Elitsa Y.

doi:10.1160/th15-05-0376

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…However, recently, resveratrol, a natural antioxidant present in grapes and various berries, has been suggested as being of use in lung fibrosis, respiratory diseases such as asthma and chronic obstructive pulmonary disease. However, even if in vitro and animal data support resveratrol use, careful clinical patient characterization is needed, since resveratrol has been shown to exert opposite effects on the hypoxia-dependent expression of the breast cancer evidence marker PAI-1 in tumour vs. primary cells (Ganjam et al 2015). Moreover, large clinical trials with resveratrol remain somewhat limited and further studies need to be performed to assess its real benefit (Conte et al 2015).…”

Section: Are Antioxidants a Treatment Option In Fibrosis?mentioning

confidence: 99%

Reactive oxygen species and fibrosis: further evidence of a significant liaison

2016

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Age-related diseases such as obesity, diabetes, non-alcoholic fatty liver disease, chronic kidney disease and cardiomyopathy are frequently associated with fibrosis. Work within the last decade has improved our understanding of the pathophysiological mechanisms contributing to fibrosis development. In particular, oxidative stress and the antioxidant system appear to be crucial modulators of processes such as transforming growth factor-β1 (TGF-β1) signalling, metabolic homeostasis and chronic low-grade inflammation, all of which play important roles in fibrosis development and persistence. In the current review, we discuss the connections between reactive oxygen species, antioxidant enzymes and TGF-β1 signalling, together with functional consequences, reflecting a concept of redox-fibrosis that can be targeted in future therapies.Graphical abstractᅟ

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Section: Are Antioxidants a Treatment Option In Fibrosis?mentioning

confidence: 99%

Reactive oxygen species and fibrosis: further evidence of a significant liaison

2016

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“…For example, RES induces apoptosis of cancerous cardiac HL1-NB cell but not normal cardiomyocytes 53 . Contrasting RES effects on gene expression of nicotinamide phosphoribosyltransferase, SIRT1 and plasminogen activator inhibitor 1 were similarly reported for hepatocarcinoma cells and primary human hepatocytes 54,55 . Numerous studies 56–58 have demonstrated that RES can activate AMPK signaling pathway at least by increasing AMPK phosphorylation, which is consistent with our finding on p-AMKP level (Fig.…”

Section: Discussionmentioning

confidence: 66%

A multi-scale approach to study biochemical and biophysical aspects of resveratrol on diesel exhaust particle-human primary lung cell interaction

Zhang

Tang

et al. 2019

Sci Rep

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Diesel exhaust particles (DEPs) are major air pollutants that lead to numerous human disorders, especially pulmonary diseases, partly through the induction of oxidative stress. Resveratrol is a polyphenol that ameliorates the production of reactive oxygen species (ROS) and delays aging-related processes. Herein we studied the cytoprotective effect of resveratrol on DEP-exposed human lung cells in a factorial experimental design. This work investigates biophysical features including cellular compositions and biomechanical properties, which were measured at the single-cell level using confocal Raman microspectroscopy (RM) and atomic force microscopy (AFM), respectively. Principal component analysis (PCA), hierarchical cluster analysis (HCA) and partial least square regression (PLS) analysis were applied to analyze Raman spectra with and without resveratrol protection. The health status of individual cells could be effectively predicted using an index derived from characteristic Raman spectral peak (e.g., 1006 cm−1) based on PLS model. AFM measurements indicated that cellular adhesion force was greatly reduced, while Young’s modulus was highly elevated in resveratrol treated DEP-exposed cells. Anti-oxidant resveratrol reduced DEP-induced ROS production and suppressed releases of several cytokines and chemokines. These findings suggest resveratrol may enhance resistance of human lung cells (e.g., SAEC) to air pollutants (e.g. DEPs).

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“…Dose-dependent effect of antioxidant (prooxidant and antioxidant theory) of the known "antioxidants" on normal and cancer cell is still not well established [66]. Nutrients such as carotenoids, tocopherol, or ascorbate derivatives show an antioxidant or pro-oxidant characteristic depending on the redox potential of the individual molecule and the inorganic chemistry of the cell [65,67,68]. We used low and high doses of extracts that relied on scavenging and TOC activity (Fig.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Antioxidant and Antiproliferative Activity of Amla and Ginger

Kulsum¹,

Suresh²,

Mehta

2018

Asian J Pharm Clin Res

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Objective: Our study focused on evaluating the anticancer property of ascorbic acid and aqueous extract of amla and ginger.Methods: Antioxidant capacity of ascorbic acid, aqueous extract of amla, and ginger was obtained by 2,2-diphenyl-1-picrylhydrazyl method and total antioxidant capacity (TAC). Vero cell line, PA-1, Cal-27, Cal-27 CisR, and DysMSCTR16 cell lines were treated with antioxidants to evaluate its antiproliferative property using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Colony and spheroid formation assays were also carried out in the presence of extracts to assess its role in anticancer stem cell activity.Results: Two volumes of amla 5 µl (~0.016 g) and 25 µl (~0.08 g) and ginger 5 µl (~0.02 g) and 25 µl (~0.1 g) showed TAC activity equivalent to 0.25 mM and 2 mM ascorbic acid, respectively. Amla and ascorbic acid showed significant antiproliferative property in normal (Vero) p=0.05, cancer (PA-1, Cal-27) p=0.005, and resistant (Cal-27 CisR) p=0.05 cell lines and ginger extract in Vero and Cal-27 cell lines (p=0.05). In PA-1 and Cal-27 CisR cell line, ginger extract showed proliferative activity (p=0.005). Antioxidants showed no antiproliferative activity in DysMSCTR16 cells. Amla extract and ascorbic acid showed significant inhibitory effect on spheroid (p=0.005) and colony formation capacity (p=0.0005) among dysplastic, cancer, and resistant cell lines. Ginger showed inhibitory effect (p=0.05) only in colony formation capacity. Conclusion:Overall, we found a strong correlation between antioxidant and antiproliferative activity of ascorbic acid, amla, and ginger. Amla and ascorbic acid proved to be effective in controlling cell proliferation and self-renewal properties of cancer cells. However, ginger was found to have selective and less antiproliferative effect in comparison to amla.

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Resveratrol: beneficial or not? Opposite effects of resveratrol on hypoxia-dependent PAI-1 expression in tumour and primary cells

Cited by 3 publications

References 27 publications

Reactive oxygen species and fibrosis: further evidence of a significant liaison

Reactive oxygen species and fibrosis: further evidence of a significant liaison

A multi-scale approach to study biochemical and biophysical aspects of resveratrol on diesel exhaust particle-human primary lung cell interaction

Correlation of Antioxidant and Antiproliferative Activity of Amla and Ginger

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