2017
DOI: 10.1080/10408398.2016.1263597
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Abdur Rauf,
Muhammad Imran,
Masood Sadiq Butt
et al.

Abstract: Owing to their antimicrobial, antioxidant, and anti-inflammatory activity, grapes (Vitis vinifera L.) are the archetypal paradigms of fruits used not only for nutritional purposes, but also for exclusive therapeutics. Grapes are a prominent and promising source of phytochemicals, especially resveratrol, a phytoalexin antioxidant found in red grapes which has both chemopreventive and therapeutic effects against various ailments. Resveratrol's role in reducing different human cancers, including breast, cervical,… Show more

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Cited by 431 publications
(274 citation statements)
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“…Finally, considering our findings, especially the role of lactate in tumor microenvironment modulation, new therapeutic strategies for advanced RCC might be envisaged. Indeed, the use of MCTs inhibitors [31] or other drugs that restore SIRT1 activity (e.g., resveratrol [55]) should be explored in order to complement current therapies, improving RCC patient outcome.…”
Section: Discussionmentioning
confidence: 99%
“…Finally, considering our findings, especially the role of lactate in tumor microenvironment modulation, new therapeutic strategies for advanced RCC might be envisaged. Indeed, the use of MCTs inhibitors [31] or other drugs that restore SIRT1 activity (e.g., resveratrol [55]) should be explored in order to complement current therapies, improving RCC patient outcome.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, previous studies showed that Gli has a wide range of anti-inflammatory effects [39, 40]. It has been shown that compounds with anti-inflammatory action also present anticancer effect [41]. …”
Section: Discussionmentioning
confidence: 99%
“…Resveratrol is a polyphenolic compound found in plant-based foods, such as red wine, berries, grapes, cocoa, and other foods. This compound is known for its potential protective effect against a number of conditions including cancer, cardiovascular disease, and respiratory illness (2,33,42). To date, three studies have assessed the impact of resveratrol on ACE2 activity.…”
Section: Biological Plausibility For Gene-diet Interactionsmentioning
confidence: 99%