Resveratrol as a factor preventing skin aging
and affecting its regeneration

Leis, Kamil; Pisanko, Karolina; Jundziłł, Arkadiusz; Mazur, Ewelina; Męcińska-Jundziłł, Kaja; Witmanowski, Henryk

doi:10.5114/ada.2022.117547

Cited by 10 publications

(6 citation statements)

References 36 publications

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“…This clinical evidence is consistent with in vivo data demonstrating the radioprotective effect of resveratrol on healthy tissue, which should be investigated in further clinical trials [ 212 ]. The radioprotective effect of the natural polyphenol has been shown by promoting skin regeneration through NF-κB modulation and stimulating collagen synthesis by acting anabolically as a phytoestrogen through the activation of estrogen receptors in keratinocytes [ 213 ]. In addition, resveratrol is hypothesized to activate VEGF to stimulate the regeneration of damaged skin tissue while enhancing the effect of radiotherapy on cancer cells ( Table 3 ), highlighting its regenerative and catabolic effects depending upon tissue type and the cell microenvironment [ 173 , 210 ].…”

Section: Resveratrolmentioning

confidence: 99%

Prevention and Co-Management of Breast Cancer-Related Osteoporosis Using Resveratrol

Meyer,

Brockmueller,

Buhrmann

et al. 2024

Nutrients

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Breast cancer (BC) is currently one of the most common cancers in women worldwide with a rising tendency. Epigenetics, generally inherited variations in gene expression that occur independently of changes in DNA sequence, and their disruption could be one of the main causes of BC due to inflammatory processes often associated with different lifestyle habits. In particular, hormone therapies are often indicated for hormone-positive BC, which accounts for more than 50–80% of all BC subtypes. Although the cure rate in the early stage is more than 70%, serious negative side effects such as secondary osteoporosis (OP) due to induced estrogen deficiency and chemotherapy are increasingly reported. Approaches to the management of secondary OP in BC patients comprise adjunctive therapy with bisphosphonates, non-steroidal anti-inflammatory drugs (NSAIDs), and cortisone, which partially reduce bone resorption and musculoskeletal pain but which are not capable of stimulating the necessary intrinsic bone regeneration. Therefore, there is a great therapeutic need for novel multitarget treatment strategies for BC which hold back the risk of secondary OP. In this review, resveratrol, a multitargeting polyphenol that has been discussed as a phytoestrogen with anti-inflammatory and anti-tumor effects at the epigenetic level, is presented as a potential adjunct to both support BC therapy and prevent osteoporotic risks by positively promoting intrinsic regeneration. In this context, resveratrol is also known for its unique role as an epigenetic modifier in the regulation of essential signaling processes—both due to its catabolic effect on BC and its anabolic effect on bone tissue.

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Section: Resveratrolmentioning

confidence: 99%

Prevention and Co-Management of Breast Cancer-Related Osteoporosis Using Resveratrol

Meyer,

Brockmueller,

Buhrmann

et al. 2024

Nutrients

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“…Undeniably, RSV is a valuable polyphenol in cosmetology, dermatology, and plastic surgery, as it is utilized in anti-aging products or administered topically on scars and lesions. Future approaches may involve RSV in the pharmacotherapy of various dermatoses [168].…”

Section: Anti-aging Propertiesmentioning

confidence: 99%

Resveratrol: A Review on the Biological Activity and Applications

Bejenaru,

Biţă,

Belu

et al. 2024

Applied Sciences

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Resveratrol (RSV), a naturally occurring phytoalexin, is the most important stilbenoid synthesized by plants as a defense mechanism in response to microbial aggression, toxins, or ultraviolet radiation. RSV came to the attention of researchers both as a potential chemopreventive agent and a possible explanation for the low incidence of cardiovascular disease (CVD) in French people with a high-fat diet. RSV is mainly administered as a food supplement, and its properties are evaluated in vitro or in vivo on various experimental models. RSV modulates signaling pathways that limit the spread of tumor cells, protects nerve cells from damage, is useful in the prevention of diabetes, and generally acts as an anti-aging natural compound. It was highlighted that RSV could ameliorate the consequences of an unhealthy lifestyle caused by an exaggerated caloric intake. This paper reviews the evidence supporting the beneficial effect of RSV for various pathological conditions, e.g., neoplastic diseases, neurodegeneration, metabolic syndrome, diabetes, obesity, CVDs, immune diseases, bacterial, viral, and fungal infections. The study also focused on the chromatographic analysis of trans-RSV (tRSV) in Romanian wine samples, providing a comprehensive overview of tRSV content across different types of wine.

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“…Undeniably, RSV is a valuable polyphenol in cosmetology, dermatology, and plastic surgery, being utilized in anti-aging products or administered topically on scars and lesions. Future approaches may involve RSV in the pharmacotherapy of various dermatoses [153].…”

Section: Anti-aging Propertiesmentioning

confidence: 99%

Resveratrol: A Review on the Biological Activity and Applications

Bejenaru,

Biţă,

Belu

et al. 2024

Preprint

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Resveratrol (RSV), a naturally occurring phytoalexin, is the most important stilbenoid synthesized by plants, as a defense mechanism, in response to microbial aggression, toxins or ultraviolet radiation. RSV came to the attention of researchers both as a potential chemopreventive agent and a possible explanation for the low incidence of cardiovascular disease (CVD) in French people with a high-fat diet. RSV is mainly administered as a food supplement, its properties being evaluated in vitro or in vivo, on various experimental models. RSV modulates signaling pathways that limit the spread of tumor cells, protects nerve cells from damage, is useful in the prevention of diabetes, and generally acts as an anti-aging natural compound. It was highlighted that RSV could ameliorate the consequences of an unhealthy lifestyle caused by an exaggerated caloric intake. This paper reviews the evidence supporting the beneficial effect of RSV for various pathological conditions, e.g., neoplastic diseases, neurodegeneration, metabolic syndrome, diabetes, obesity, CVDs, immune diseases, bacterial, viral, and fungal infections. The study also focused on the chromatographic analysis of trans-RSV (tRSV) in Romanian wine samples, providing a comprehensive overview of tRSV content across different types of wine.

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Resveratrol as a factor preventing skin aging and affecting its regeneration

Cited by 10 publications

References 36 publications

Prevention and Co-Management of Breast Cancer-Related Osteoporosis Using Resveratrol

Prevention and Co-Management of Breast Cancer-Related Osteoporosis Using Resveratrol

Resveratrol: A Review on the Biological Activity and Applications

Resveratrol: A Review on the Biological Activity and Applications

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