Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical

Sueishi, Yoshimi; Nii, Risako; Kakizaki, Naru

doi:10.1016/j.bmcl.2017.10.045

Cited by 35 publications

(29 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, it has been reported that, compared with other antioxidants, O 2 • − scavenging activity of RSV is high [38,50,51], However, using the xanthine-xanthine oxidase system, we observed that the antioxidant effect of RSV is related to the inhibition of the production of O 2 • − and, furthermore, to its neutralization. Therefore, we could not compare the activity of the extracts with RSV.…”

Section: Discussioncontrasting

confidence: 65%

Antioxidant Properties and Protective Effects of Some Species of the Annonaceae, Lamiaceae, and Geraniaceae Families against Neuronal Damage Induced by Excitotoxicity and Cerebral Ischemia

et al. 2020

View full text Add to dashboard Cite

This study aimed to compare the antioxidant activities of extracts obtained from three plant families and evaluate their therapeutic effect on strokes. Ethanol extracts were obtained from either the leaf or the aerial parts of plants of the families Annonaceae (Annona cherimola, A. diversifolia, A. muricata, A. purpurea, and A. reticulata), Lamiaceae (Salvia amaríssima and S. polystachya), and Geraniaceae (Geranium niveum and G. mexicanum). Extracts were analyzed in terms of hydroxyl radical (OH•), peroxyl radical (ROO•), and superoxide anion (O2•−). The efficiency of the extracts to prevent neuronal death induced by excitotoxicity was tested with the tetrazolium assay, the O2•− scavenging capacity was evaluated with the dihydroethidium dye, and the protective effect of the extracts with the highest antioxidant activity was tested on a stroke experimental model. The extracts’ IC50 values (μg/mL) of scavenging varied from 98.9 to 155.04, 4.5 to 102.4, and 20.2 to 118.97 for OH•, ROO•, and O2•−, respectively. In the excitotoxicity model, Annonaceae extracts were highly cytotoxic while Lamiaceae and Geraniaceae reduced intracellular O2•− production and protect neurons against oxidative stress. Salvia polystachya reduced cerebral damage, as well as improved survival and behavior after ischemia. Our results encouraged the use of plant extracts as natural antioxidants to minimize neuronal injury following stroke.

show abstract

Section: Discussioncontrasting

confidence: 65%

Antioxidant Properties and Protective Effects of Some Species of the Annonaceae, Lamiaceae, and Geraniaceae Families against Neuronal Damage Induced by Excitotoxicity and Cerebral Ischemia

et al. 2020

View full text Add to dashboard Cite

show abstract

“…[6][7][8][9][10][11][12][13][14][15][16] As one of the antioxidant polyphenols found in red wine, resveratrol and its derivatives gained much attention. 6,8,9,11,12,15,17,18 Several studies demonstrated that the radical scavenging abilities of resveratrol and its metabolite piceatannol are higher than that of Trolox, the universally accepted benchmark. 6,8,11,15 The effect of derivatization of resveratrol has also been studied: longer conjugated chain or complexation with macromolecules could improve the antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

A theoretical study of the radical scavenging activity of natural stilbenes

Nam

Bay

et al. 2019

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…In addition, XIAP represents a group of structurally interrelated proteins that block apoptosis in the heart of the apoptotic machinery by cooperating with Bcl-2. 13) Recent study confirmed that knockdown or low expression of XIAP inhibits HCT116 cell invasion and migration, and that the restoration of XIAP expression reverses these effects. 25) XIAP is constitutively expressed in a variety of malignant tumors including prostate cancer, hepatoma, as well as acute and chronic leukemia.…”

Section: Discussionmentioning

confidence: 87%

“…Since simultaneous inhibition of XIAP and Bcl-2 renders cells sensitive to apoptosisinducing agents, 13) we investigated whether piceatannol downregulates XIAP expression, which would point to a novel mechanism for piceatannol-induced apoptosis. As expected, piceatannol significantly downregulated XIAP expression in THP-1 and U937 cells, much less prominent in HL60 and K562 cells (Fig.…”

Section: Nac Reverses Piceatannol-induced Apoptosis Through Recovery mentioning

confidence: 99%

Piceatannol-Induced Apoptosis Is Reversed by <i>N</i>-Acetyl-L-cysteine through Restoration of XIAP Expression

Jin

Molagoda

Park

et al. 2018

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Piceatannol, a naturally occurring stilbene derivative mainly found in grapes, possesses apoptotic activity in various cancer cell lines, in addition to potent antioxidant activity. In the current study, we showed that piceatannol exhibits potent cytotoxic effects in all tested leukemia cell lines (THP-1, HL-60, U937, and K562). These effects were accompanied by induction of DNA damage, an increase in the proportion of cells in the sub-G phase of the cell cycle, and inhibition of reactive oxygen species (ROS) generation. However, N-acetyl-L-cysteine (NAC), a strong ROS scavenger, significantly inhibited piceatannol-induced apoptosis, suggesting that piceatannol-induced apoptosis does not occur via inhibition of ROS generation. Piceatannol also resulted in a significant increase in mitochondrial depolarization, along with a decline in Bcl-2 expression, which was not restored by NAC. Conversely, ectopic Bcl-2 overexpression moderately inhibited piceatannol-induced apoptosis. Furthermore, piceatannol strongly inhibited X-linked inhibitor of apoptosis protein (XIAP) expression, which was restored by NAC. A transient knockdown of XIAP significantly increased piceatannol-induced apoptosis in the presence of NAC, suggesting that XIAP downregulation increases piceatannol-induced apoptosis, and that NAC could reverse this effect by increasing XIAP expression. Taken together, these results suggest that piceatannol induces apoptosis in human leukemia cell lines by downregulating XIAP expression, regardless of antioxidant activity.

show abstract

Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical

Cited by 35 publications

References 19 publications

Antioxidant Properties and Protective Effects of Some Species of the Annonaceae, Lamiaceae, and Geraniaceae Families against Neuronal Damage Induced by Excitotoxicity and Cerebral Ischemia

Antioxidant Properties and Protective Effects of Some Species of the Annonaceae, Lamiaceae, and Geraniaceae Families against Neuronal Damage Induced by Excitotoxicity and Cerebral Ischemia

A theoretical study of the radical scavenging activity of natural stilbenes

Piceatannol-Induced Apoptosis Is Reversed by <i>N</i>-Acetyl-L-cysteine through Restoration of XIAP Expression

Contact Info

Product

Resources

About