Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ

Cheang, Wai San; Wong, Wing Tak; Wang, Li; Cheng, Chak Kwong; Lau, Chi Wai; Ma, Rong; Xu, Aimin; Wang, Nanping; Huang, Yü; Tian, Xiaoyu

doi:10.1016/j.phrs.2018.11.041

Cited by 63 publications

(48 citation statements)

References 56 publications

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“…Through the SIRT1/PPAR‐α cascade, resveratrol exerts anti‐inflammatory and anti‐hypertrophic effects by lowering the expression of the pro‐inflammatory cytokine CCL2 and atrial natriuretic peptide in Sprague‐Dawley rat cardiomyocytes (Planavila et al, ). Also, resveratrol ameliorates endothelial dysfunction in obese and diabetic mice through a SIRT1/PPARδ pathway (Cheang et al, ), supporting the vaso‐protective effect of resveratrol. Resveratrol‐induced SIRT1/PPARδ signalling is a new mechanism that benefits the cardiovascular function.…”

Section: Molecular Basis Of Resveratrol Actionmentioning

confidence: 90%

“…PPARδ was previously shown to be required to ameliorate endothelial dysfunction in exercise‐trained diabetic mice (Cheang et al, ). Similarly, resveratrol improves endothelial function in a PPARδ‐dependent manner (Cheang et al, ). In addition, both GW501516, a PPARδ receptor agonist, and resveratrol inhibit oxLDL‐induced migration and proliferation of vascular SMCs, probably through the SIRT1/PPARδ signalling transduction as well (Hwang et al, ).…”

Section: Molecular Basis Of Resveratrol Actionmentioning

confidence: 99%

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Pharmacological basis and new insights of resveratrol action in the cardiovascular system

Cheng

Luo

Lau

et al. 2019

British J Pharmacology

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104

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Resveratrol (trans‐3,4′,5‐trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports of the cardioprotective effects of red wine. Thereafter, resveratrol was shown to exert antioxidant, anti‐inflammatory, anti‐proliferative, and angio‐regulatory effects against atherosclerosis, ischaemia, and cardiomyopathy. This article critically reviews the current findings on the molecular basis of resveratrol‐mediated cardiovascular benefits, summarizing the broad effects of resveratrol on longevity regulation, energy metabolism, stress resistance, exercise mimetics, circadian clock, and microbiota composition. In addition, this article also provides an update, both preclinically and clinically, on resveratrol‐induced cardiovascular protection and discusses the adverse and inconsistent effects of resveratrol reported in both preclinical and clinical studies. Although resveratrol has been claimed as a master anti‐aging agent against several age‐associated diseases, further detailed mechanistic investigation is still required to thoroughly unravel the therapeutic value of resveratrol against cardiovascular diseases at different stages of disease development. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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Section: Molecular Basis Of Resveratrol Actionmentioning

confidence: 90%

Section: Molecular Basis Of Resveratrol Actionmentioning

confidence: 99%

Pharmacological basis and new insights of resveratrol action in the cardiovascular system

Cheng

Luo

Lau

et al. 2019

British J Pharmacology

Self Cite

104

View full text Add to dashboard Cite

show abstract

“…Previous studies have indicated the beneficial effects of sirtuins as the best small molecule that activate sirtuins, which extended lifespan in a yeast model [104][105][106][107][108][109]. Although only the longevity extension effect of resveratrol has been reported in C. elegans and D. melanogaster, many subsequent studies reported that resveratrol intake promotes health and plays a preventive role in age-related diseases, such as cancer [110][111][112][113], atherosclerosis [114,115], arthritis [116,117], cataract [118][119][120], cardiovascular disease [121], hypertension [122,123], type 2 diabetes [124][125][126][127], osteoporosis [128][129][130], and Alzheimer disease [131][132][133]. In clinical studies, resveratrol intake improved the memory capacity of elderly individuals and reduced blood lipid levels in obese and type 2 diabetic patients [134,135].…”

Section: Resveratrolmentioning

confidence: 99%

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

et al. 2020

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Chronic inflammation, a pervasive feature of the aging process, is defined by a continuous, multifarious, low-grade inflammatory response. It is a sustained and systemic phenomenon that aggravates aging and can lead to age-related chronic diseases. In recent years, our understanding of age-related chronic inflammation has advanced through a large number of investigations on aging and calorie restriction (CR). A broader view of age-related inflammation is the concept of senoinflammation, which has an outlook beyond the traditional view, as proposed in our previous work. In this review, we discuss the effects of CR on multiple phases of proinflammatory networks and inflammatory signaling pathways to elucidate the basic mechanism underlying aging. Based on studies on senoinflammation and CR, we recognized that senescence-associated secretory phenotype (SASP), which mainly comprises cytokines and chemokines, was significantly increased during aging, whereas it was suppressed during CR. Further, we recognized that cellular metabolic pathways were also dysregulated in aging; however, CR mimetics reversed these effects. These results further support and enhance our understanding of the novel concept of senoinflammation, which is related to the metabolic changes that occur in the aging process. Furthermore, a thorough elucidation of the effect of CR on senoinflammation will reveal key insights and allow possible interventions in aging mechanisms, thus contributing to the development of new therapies focused on improving health and longevity.

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“…Recent researches emphasize that overexpressing or activating SIRT1 inhibits hepatic senescence and activation of HSCs to ameliorate liver fibrosis [11,12]. Besides, a major finding demonstrates that the activation of SIRT1 prevents endothelial cell from oxidative stress-induced senescence and dysfunction [13,14]. Nevertheless, the effects of SIRT1 on premature senescence and defenestration in HSECs in liver fibrosis remain elusive.…”

Section: Introductionmentioning

confidence: 99%

SIRT1 ameliorates premature senescence-induced defenestration in hepatic sinusoidal endothelial cell

Bai

et al. 2020

Preprint

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Premature senescence, linked to progerin, involves in endothelial dysfunction and liver diseases. Activating sirtuin 1 (SIRT1) ameliorates liver fibrosis. However, the potential mechanisms of premature senescence in defenestration in hepatic sinusoidal endothelial cells (HSECs) and how SIRT1 affects fenestrae remains elusive. Our study showed that in vivo, premature senescence occurred, with decrease of SIRT1, during CCl 4 -induced defenestration in HSECs and liver fibrogenesis; whereas overexpressing SIRT1 with adenovirus vector lessened progerin-associated premature senescence to relieve CCl 4 -induced defenestration and liver fibrosis. In vitro, fenestrae in HSECs disappeared, with progerin-associated premature senescence; these effects aggravated by H 2 O 2 -induced oxidative damage. Nevertheless, knockdown of NOX2 or overexpression of SIRT1 with adenovirus vector reduced progerin-associated premature senescence to maintain fenestrae through deacetylating p53. Furthermore, more Ac p53 K381 and progerin co-localized with accumulation of actin filament (F-actin) in the nuclear envelope of H 2 O 2 -treated HSECs; in contrast, these effects were rescued by overexpressing SIRT1. In conclusion, NOX2-dependent oxidative damage aggravates defenestration in HSECs via progerin-associated premature senescence; SIRT1-mediated deacetylation of p53 maintains fenestrae and attenuates liver fibrogenesis through inhibiting premature senescence.

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Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ

Cited by 63 publications

References 56 publications

Pharmacological basis and new insights of resveratrol action in the cardiovascular system

Pharmacological basis and new insights of resveratrol action in the cardiovascular system

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

SIRT1 ameliorates premature senescence-induced defenestration in hepatic sinusoidal endothelial cell

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