Resumption of Menses in Anorexia Nervosa

Golden, Neville H.; Jacobson, Mark Z.; Schebendach, Janet; Solanto, Mary V.; Hertz, Stanley; Shenker, I. Ronald

doi:10.1001/archpedi.1997.02170380020003

Cited by 246 publications

(199 citation statements)

References 20 publications

Supporting

Mentioning

173

Contrasting

Unclassified

Order By: Relevance

“…Resumption of menses is one indicator of return to biological health and we have suggested that weight at ROM is a reasonable treatment goal weight. We have shown that 86% of adolescent girls resume menses within 6 months of achieving a weight at or above 90% of median body weight for age and height, 9 which, using the results of this present study, translates to a BMI percentile of 27. Fifty percent of girls with AN who resumed menses, did so when they achieved a weight between the 14th and 39th BMI percentile for age and 75% did so at a BMI percentile below the 39th percentile.…”

Section: Discussionsupporting

confidence: 63%

“…Our data suggest that in postmenarcheal girls, a BMI at or above the 27th percentile is sufficient for ROM and, based on our prior findings, the majority of patients who achieve this BMI percentile will resume menses within 3-6 months. 9 Resistance to weight gain is one of the core features of patients with eating disorders. Most patients with AN were not overweight before the onset of the eating disorder.…”

Section: Discussionmentioning

confidence: 99%

“…We have previously shown that an estradiol level above 30 pg/mL (110 pmol/L) is predictive of ROM within 3-6 months (RR 4.6, 95% CI 1.9-11.2). 9 If after 6 months, estradiol levels still remain low, the individualized treatment goal weight needs to be higher.…”

Section: Discussionmentioning

confidence: 99%

“…We have previously shown that, in a cohort of 100 adolescent girls with AN, a weight 90% of median weight for age and height (using the NCHS tables) is the average weight at ROM and 86% of participants who achieved this weight, resumed menses within 6 months of achieving this weight. 9 We suggested that this weight represents a reasonable treatment goal weight for postmenarcheal adolescent girls with AN. Most practitioners do not have access to the NCHS tables which are required to determine median weight for age and height, but the CDC BMI percentiles for age and sex are readily available (www.cdc.gov).…”

Section: Introductionmentioning

confidence: 97%

See 3 more Smart Citations

Treatment goal weight in adolescents with anorexia nervosa: Use of BMI percentiles

Golden

Jacobson

Sterling

et al. 2008

Intl J Eating Disorders

Self Cite

View full text Add to dashboard Cite

Objective: There is a lack of consensus as to how to determine treatment goal weight in the growing adolescent with anorexia nervosa (AN). Resumption of menses (ROM) is an indicator of biological health and weight at ROM can be used as a treatment goal weight. This study determined the BMI percentile for age at which ROM occurs.Method: A secondary analysis of a prospective cohort study examining 56 adolescent females with AN, aged 12-19 years, followed every 3 months until ROM. BMI percentiles for age and gender at ROM were determined using the nutrition module of Epi Info 2002.Results: At 1-year follow-up, 36 participants (64.3%) resumed menses and 20 (35.7%) remained amenorrheic. Mean BMI percentile at ROM was 27.1 (95% CI 5 20.0-34.2). Fifty percent of participants who resumed menses, did so at a BMI percentile between the 14th and 39th percentile. Conclusion:A BMI percentile range of 14th-39th percentile can be used to assign a treatment goal weight, with adjustments for prior weight, stage of pubertal development, and anticipated growth. V V C 2008 by Wiley Periodicals, Inc.

show abstract

Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Treatment goal weight in adolescents with anorexia nervosa: Use of BMI percentiles

Golden

Jacobson

Sterling

et al. 2008

Intl J Eating Disorders

Self Cite

View full text Add to dashboard Cite

show abstract

“…This weight was approximately 2 kg greater than the weight at which the adolescents lost their menstrual periods (menstrual threshold weight). 46 Calcium is important for attaining skeletal health during adolescent growth and development. Dietary calcium requirements increase during periods of peak velocity of growth and bone mineral content.…”

Section: Osteoporosismentioning

confidence: 99%

Medical complications in adolescents with anorexia nervosa: A review of the literature

Katzman

2005

Int. J. Eat. Disord.

321

209

View full text Add to dashboard Cite

Randomized Clinical Trial Comparing Family-Based Treatment With Adolescent-Focused Individual Therapy for Adolescents With Anorexia Nervosa

Lock

Grange²,

Agras³

et al. 2010

Arch Gen Psychiatry

749

643

View full text Add to dashboard Cite

Context Evidence-based treatment trials for adolescents with anorexia nervosa are few. Objective To evaluate the relative efficacy of family-based treatment (FBT) and adolescent focused individual therapy (AFT) for adolescents with anorexia nervosa on full remission. Design Randomized controlled trial. Setting Stanford University and The University of Chicago (April 2005 until March 2009) Participants One hundred and twenty one participants, ages 12 through 18 years with DSM-IV diagnosis of anorexia nervosa except for not requiring ammenorhea. Interventions Twenty four outpatient hours of treatment over 12 months of FBT or AFT. Participants were assessed at baseline, end of treatment (EOT), 6 months and 12 months follow-up post treatment. Main outcome measures Full remission from anorexia nervosa defined as normal weight (>95% of expected gender, age, weight for height) and mean global Eating Disorder Examination (EDE) score within 1 standard deviation of published means. Secondary outcome measures included partial remission rates (>85% of expected weight for height plus those who were fully remitted) and changes in Body Mass Index (BMI) percentile and eating related psychopathology. Results There were no differences in full remission between treatments at EOT. However, at both 6 and 12 month follow-up FBT was significantly superior to AFT on this measure. FBT was significantly superior for partial remission at EOT but not at follow-up. In addition, BMI percentile at EOT was significantly superior for FBT, but this effect was not found at follow-up. Participants in FBT also had greater changes on the EDE at EOT than those in AFT, but there were no differences at follow-up. Conclusions Although both treatments led to considerable improvement and were similarly effective in producing full remission at EOT, FBT was more effective in facilitating full remission at both follow-up points. Clinical Trials Registry Effectiveness of Family-Based Versus Individual Psychotherapy in Treating Adolescents With Anorexia Nervosa (NCT00149786)

show abstract

Resumption of Menses in Anorexia Nervosa

Cited by 246 publications

References 20 publications

Treatment goal weight in adolescents with anorexia nervosa: Use of BMI percentiles

Treatment goal weight in adolescents with anorexia nervosa: Use of BMI percentiles

Medical complications in adolescents with anorexia nervosa: A review of the literature

Randomized Clinical Trial Comparing Family-Based Treatment With Adolescent-Focused Individual Therapy for Adolescents With Anorexia Nervosa

Contact Info

Product

Resources

About