Results of nonablative wrinkle reduction with a 1,450-nm diode laser: Difficulties in the assessment of “subtle changes”

Hohenleutner, Sílvía; Koellner, K.; Lorenz, Susanne; Landthaler, Míchael; Hohenleutner, Ulrích

doi:10.1002/lsm.20181

Cited by 16 publications

(8 citation statements)

References 29 publications

(36 reference statements)

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“…The prolonged recovery time and significant risk profile associated with the highly effective ablative techniques prompted the development of nonablative and fractional methods [3, 4]. Nonablative fractional photothermolysis creates thermal damage in the dermis without causing significant epidermal removal or injury.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of minimally invasive nonthermal laser-induced optical breakdown technology for skin rejuvenation

Habbema¹,

Verhagen

Hal

et al. 2012

Lasers Med Sci

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We demonstrate the efficacy of a novel minimally invasive nonthermal skin rejuvenation technique for wrinkle and fine-line reduction based on laser-induced optical breakdown. The optical breakdown caused by tightly focused near-infrared laser pulses creates a grid of intradermal lesions without affecting the epidermis, leading to skin rejuvenation. The pilot in vivo efficacy test performed on five subjects successfully demonstrates wrinkle and fine‐line reduction, and improvement of other skin features without pain or any other unpleasant sensations or any social downtime associated with the treatment. The efficacy is evaluated objectively and subjectively by assessing the improvement of wrinkles and/or fine lines or skin texture after the treatment. The treatment is safe without side effects or social downtime, and all test subjects reported that the treatment is “perceptible but not painful.” Four out of the five subjects who participated in this pilot study were assessed to have “minor” to “significant” improvements of wrinkles and fine lines by the professional panels. The results of this clinical study are expected to bring a paradigm shift in the present laser- and light-based skin rejuvenation methods by introducing a safe treatment procedure without damaging the epidermis, with no or little social downtime and with an efficacy that might be comparable to ablative techniques.

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Section: Introductionmentioning

confidence: 99%

Efficacy of minimally invasive nonthermal laser-induced optical breakdown technology for skin rejuvenation

Habbema¹,

Verhagen

Hal

et al. 2012

Lasers Med Sci

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“…In general, ablative laser surgery using CO 2 or erbium:yttrium aluminium garnet (Er:YAG) laser applied in a conventional manner has been demonstrated to be the most effective option [1][2][3][4]. However, these treatment modalities have been frequently associated with significant downtime, delayed reepithelialization, prolonged erythema, and in some instances resulted in scarring and post-inflammatory hypopigmentation [5][6][7], whereas non-ablative lasers create less side effects [8][9][10][11], and produce limited albeit reasonable efficacy [12][13].…”

Section: Introductionmentioning

confidence: 99%

Histological comparison of two different fractional photothermolysis devices operating at 1,550 nm

2010

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“…Although most studies have indicated significant levels of patient satisfaction and even histological and biochemical evidence of improvement, photographic assessment by blinded observers has often found only minimal or no improvement. Thus, limited clinical efficacy is the major disadvantage of this technique compared to ablative laser skin resurfacing [16,17].…”

Section: Discussionmentioning

confidence: 99%

Effects of skin temperature on lesion size in fractional photothermolysis

et al. 2007

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Background and Objectives: Fractional photothermolysis is a new concept in cutaneous re-modeling whereby laser-induced microscopic zones of thermal injury (MTZMicroscopic Treatment Zones) are surrounded by normal, viable tissue. This unique thermal damage pattern allows re-epithelialization in less than 24 hours. To increase patient comfort level during the procedure of fractional photothermolysis, simultaneous skin cooling has been proposed and is now extensively used. The purpose of this in vitro study was to examine the influence of skin temperature on the diameter of the epidermal microthermal zone and the extent of thermal injury per unit area. The determination of the changes in these parameters that are due to skin temperature will allow the better control and understanding of fractional photothermolysis at different skin temperatures. Materials and Methods: Fractional photothermolysis was performed with a 1,550 nm fiber laser (Fraxel SR 1 Laser) with 10 mJ per pulse on full-thickness cadaver skin. The skin samples were brought prior to exposure to temperatures that ranged from 0 to 458C. The epidermis of the skin samples was separated by dispase treatment, stained for thermal damage by NBTC stain, and lesion diameter was assessed by a blinded investigator. Results : The average MTZ diameter exhibits a positive, linear relationship with skin temperature (R 2 ¼ 0.904, P < 0.0001). As the skin temperature increases from 0 to 458C. The MTZ diameter increases from 93 to 147 mm (58%), and the MTZ area from 6,870 to 17,050 mm 2 (148%). Conclusion : The skin temperature affects the size of epidermal MTZs during fractional photothermolysis and is an important variable factor. The use of simultaneous skin cooling increases patient comfort; however, as it also decreases MTZ size, it may interfere with treatment efficacy. The control of skin temperature is necessary to provide a consistent outcome and to be able to compare treatments.

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Results of nonablative wrinkle reduction with a 1,450-nm diode laser: Difficulties in the assessment of “subtle changes”

Abstract: Our study failed to provide convincing data on the efficacy of nonablative treatment of rhytides with the 1,450 nm diode laser. In this respect, we challenge objective judgment in the assessment of subtle changes in nonablative wrinkle reduction.

Cited by 16 publications

References 29 publications

Efficacy of minimally invasive nonthermal laser-induced optical breakdown technology for skin rejuvenation

Efficacy of minimally invasive nonthermal laser-induced optical breakdown technology for skin rejuvenation

Histological comparison of two different fractional photothermolysis devices operating at 1,550 nm

Effects of skin temperature on lesion size in fractional photothermolysis

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