Results of carbon ion radiotherapy for skin carcinomas in 45 patients

Zhang, Hao; Li, Shaoyang; Wang, X.H.; Li, Q.; Sun, Wen‐Rong; Gao, Li; Zhao, Weiping; Hu, Zhengguo; Mao, Ruishi; Han, Xu; Zhang, Q.N.; Yue, Yangjun; Tian, Zhixin; Ran, Jun; Xiao, Guoqing; Wenlong, Zhan

doi:10.1111/j.1365-2133.2011.10764.x

Cited by 19 publications

(22 citation statements)

References 31 publications

(61 reference statements)

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“…Our own studies have shown that carbon ion radiotherapy offers a high degree of control for targeting tumors and increases progression-free survival rates without significant radiation-induced toxicity in skin carcinoma patients [5].…”

Section: Introductionmentioning

confidence: 99%

Carbon Ion Radiation Inhibits Glioma and Endothelial Cell Migration Induced by Secreted VEGF

et al. 2014

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This study evaluated the effects of carbon ion and X-ray radiation and the tumor microenvironment on the migration of glioma and endothelial cells, a key process in tumorigenesis and angiogenesis during cancer progression. C6 glioma and human microvascular endothelial cells were treated with conditioned medium from cultures of glioma cells irradiated at a range of doses and the migration of both cell types, tube formation by endothelial cells, as well as the expression and secretion of migration-related proteins were evaluated. Exposure to X-ray radiation-conditioned medium induced dose-dependent increases in cell migration and tube formation, which were accompanied by an upregulation of vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)-2 and -9 expression. However, glioma cells treated with conditioned medium of cells irradiated at a carbon ion dose of 4.0 Gy showed a marked decrease in migratory potential and VEGF secretion relative to non-irradiated cells. The application of recombinant VEGF165 stimulated migration in glioma and endothelial cells, which was associated with increased FAK phosphorylation at Tyr861, suggesting that the suppression of cell migration by carbon ion radiation could be via VEGF-activated FAK signaling. Taken together, these findings indicate that carbon ion may be superior to X-ray radiation for inhibiting tumorigenesis and angiogenesis through modulation of VEGF level in the glioma microenvironment.

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Section: Introductionmentioning

confidence: 99%

Carbon Ion Radiation Inhibits Glioma and Endothelial Cell Migration Induced by Secreted VEGF

et al. 2014

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“…With this approach, the RBE weighted rather than the absorbed dose is optimized, prescribed, recorded, and reported. More recently, also IMP has implemented a model to modulate the absorbed dose according to the variation of the RBE …”

Section: Introductionmentioning

confidence: 99%

“…More recently, also IMP has implemented a model to modulate the absorbed dose according to the variation of the RBE. 25 It is evident that the same RBE weighted dose may result in two rather different treatments, if different RBE models are used. To understand the limits of retrospective comparison of CIRT results at different institution, to reproduce established clinical results in new facilities, and finally to rationally plan multicentric cooperative clinical trials, it is therefore mandatory to understand the general principles behind the different RBE models and the way they are applied clinically.…”

Section: Introductionmentioning

confidence: 99%

Radiobiological issues in prospective carbon ion therapy trials

Fossati

Matsufuji²,

Kamada³

et al. 2018

Medical Physics

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Carbon ion radiotherapy (CIRT) is developing toward a versatile tool in radiotherapy; however, the increased relative biological effectiveness (RBE) of carbon ions in tumors and normal tissues with respect to photon irradiation has to be considered by mathematical models in treatment planning. As a consequence, dose prescription and definition of dose constraints are performed in terms of RBE weighted rather than absorbed dose. The RBE is a complex quantity, which depends on physical variables, such as dose and beam quality as well as on normal tissue‐ or tumor‐specific factors. At present, three RBE models are employed in CIRT: (a) the mixed‐beam model, (b) the Microdosimetric Kinetic Model (MKM), and (c) the local effect model. While the LEM is used in Europe, the other two models are employed in Japan, and unfortunately, the concepts of how the nominal RBE‐weighted dose is determined and prescribed differ significantly between the European and Japanese centers complicating the comparison, transfer, and reproduction of clinical results. This has severe impact on the way treatments should be prescribed, recorded, and reported. This contribution reviews the concept of the clinical application of the different RBE models and the ongoing clinical CIRT trials in Japan and Europe. Limitations of the RBE models and the resulting radiobiological issues in clinical CIRT trials are discussed in the context of current clinical evidence and future challenges.

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“…Radiation therapy has remained the mainstay of treatment for glioblastoma, but these tumors are often associated with radioresistance (1). Heavy ions represent the best tool for various tumors, especially for radioresistant tumors mediated by hypoxia, due to several advantages over conventional radiotherapy (gamma and X-rays) such as an inverted depthdose distribution, a higher relative biological effectiveness, a reduction in oxygen enhancement ratio, less variation in cell cycle related sensitivity and cells having decreased ability to repair (2).…”

Section: Introductionmentioning

confidence: 99%

Contribution of caspase-independent pathway to apoptosis in malignant glioma induced by carbon ion beams

et al. 2017

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High linear energy transfer (LET) carbon ion beam (CIB) is becoming the best tool for external radiotherapy of inoperable tumors because of its greater cell killing than conventional low LET gamma or X-rays. In the present study, whether the caspase-independent pathway exerts the important contribution in CIB-induced cell apoptosis was explored. Herein we showed, despite the absence of caspase activity using a pan caspase inhibitor Z-VAD-FMK, that apoptosis induced by high LET CIB were clearly observed in the glioma cells. Simultaneously, the increased 8-OHdG level, PARP-1 activity and AIF translocation occurred in response to CIB irradiation. Moreover, it was distinctly higher in the nuclear translocation frequency along with PARP-1 activation when the caspase protease cascade was suppressed in the irradiated glioma cells. Nuclear colocalization between PARP-1 and AIF as well as a positive association of the PARP-1 mRNA expression with AIF translocation frequency indicated that PARP-1 activation controlled the translocation of AIF to the nucleus. Our findings strongly demonstrated that caspase-independent cell apoptosis provided a prominent compensation in the glioma cell death involving the PARP-1/AIF signaling pathway at 24 h after CIB exposure, and likely triggered by oxidative damage to DNA. The knowledge on the molecular mechanism of AIF-mediated cell death may be very useful for the improvement of the therapeutic efficacy of malignant gliomas with heavy charged particles.

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Results of carbon ion radiotherapy for skin carcinomas in 45 patients

Abstract: The results demonstrated that heavy ion RT offers high local tumour control and progression-free survival rates without significant radiation-induced toxicity for patients with skin carcinomas.

Cited by 19 publications

References 31 publications

Carbon Ion Radiation Inhibits Glioma and Endothelial Cell Migration Induced by Secreted VEGF

Carbon Ion Radiation Inhibits Glioma and Endothelial Cell Migration Induced by Secreted VEGF

Radiobiological issues in prospective carbon ion therapy trials

Contribution of caspase-independent pathway to apoptosis in malignant glioma induced by carbon ion beams

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