Results of a Surgical Resection for Patients With Stage IV Non–Small-Cell Lung Cancer

Hanagiri, Takeshi; Takenaka, Masaru; Oka, Soich; Shigematsu, Yoshiki; Nagata, Yoshika; Shimokawa, Hidehiko; Uramoto, Hidetaka; Tanaka, Fumihiro

doi:10.1016/j.cllc.2011.05.006

Cited by 46 publications

(39 citation statements)

References 32 publications

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“…36 For patients with only one metastatic lesion, 5-year survival was approximately 50% after surgery, compared to only 17% for patients undergoing surgery with five metastatic lesions (p<0.001). The nodal status of oligometastatic lung cancer patients also significantly impacts their survival status.…”

Section: Resultsmentioning

confidence: 91%

“…Several groups have recently published small series detailing outcomes of the management of patients with oligometastatic NSCLC to sites other than the brain and adrenal glands. 17,20,36,38,41,44 (Table 1) For example, Congedo et al describe a series of 53 patients with oligometastatic disease to diverse sites, including the brain, adrenal gland, bone, vertebrae, liver and contralateral supraclavicular lymph nodes. All patients were treated with resection of the primary tumor and aggressive local therapy to all sites of metastatic disease with either surgical resection or radiation.…”

Section: Resultsmentioning

confidence: 99%

“…36,51–57 In a report by Hanagiri et al, there were 36 patients who underwent resection for metastatic NSCLC, of whom 17 patients had ipsilateral pleural dissemination . 36 For their entire cohort, 5-year survival was 26.8%, and in the patients with pleural dissemination it was 25.3%. In the context of metastatic NSCLC, these results are favorable given that survival for historical controls is on the order of 3 – 6 months, although important questions of selection bias and generalizability of the results remain.…”

Section: Resultsmentioning

confidence: 99%

“…Notably, six of 19 patients (31.6%) were 3-year survivors, and it seems reasonable to hypothesize based on these data that patients with pleural dissemination may derive some therapeutic benefit from extirpative surgery. 36 …”

Section: Resultsmentioning

confidence: 99%

“…36 Liu et al retrospectively analyzed 80 patients who underwent surgical resection for M1a disease. The authors included patients with pleural nodules, pleural effusion, contralateral lung metastasis, diaphragm nodules, and pericardial nodules.…”

Section: Resultsmentioning

confidence: 99%

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The Role of Thoracic Surgery in the Therapeutic Management of Metastatic Non–Small Cell Lung Cancer

David

Clark

Cooke

et al. 2017

Journal of Thoracic Oncology

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Introduction The majority of non-small cell lung cancer (NSCLC) patients are diagnosed with advanced stage disease for whom the prognosis is poor and survival is typically measured in months. Standard therapeutic treatment regimens for patients with stage IV NSCLC typically include chemotherapy and palliative radiation. Despite newer regimens that may include molecularly targeted therapy and immunotherapy, the overall 5-year survival for stage IV disease remains low at 4–6%. Although therapeutic surgery is performed in a minority of cases, accumulating data suggest that thoracic surgery may play several beneficial roles for these patients. Methods In this narrative review, we summarize the literature on surgical intervention in the multimodality management of stage IV NSCLC; focusing on the potential evidence for and against therapeutic/curative intent procedures to impact outcomes for patients with oligometastatic disease and pleural metastasis. Results In selected patients, surgical resection can result in a 5-year survival of 30–50%, but this is heavily influenced by the presence of mediastinal nodal disease, which should be evaluated before therapeutic surgical procedures are undertaken. Additionally, diagnostic or palliative surgical procedures can play an important role in the personalized management of stage IV disease. These data suggest that for carefully selected patients with advanced stage NSCLC, surgical intervention can be an important component of combined modality treatment. Conclusions Given advances in molecular targeted therapy and immunotherapy, further studies should focus on the possible use of surgery as a strategy of therapeutic “consolidation” for appropriately selected patients with stage IV NSCLC receiving combined modality care.

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Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

The Role of Thoracic Surgery in the Therapeutic Management of Metastatic Non–Small Cell Lung Cancer

David

Clark

Cooke

et al. 2017

Journal of Thoracic Oncology

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Patient perceptions regarding the likelihood of cure after surgical resection of lung and colorectal cancer

Kim

Winner

Page

et al. 2015

Cancer

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BACKGROUND The objective of the current study was to characterize the prevalence of the expectation that surgical resection of lung or colorectal cancer might be curative. The authors sought to assess patient-level, tumor-level, and communication-level factors associated with the perception of cure. METHODS Between 2003 and 2005, a total of 3954 patients who underwent cancer-directed surgery for lung (30.3%) or colorectal (69.7%) cancer were identified from a population-based and health system-based survey of participants from multiple US regions. RESULTS Approximately 80.0% of patients with lung cancer and 89.7% of those with colorectal cancer responded that surgery would cure their cancer. Even 57.4% and 79.8% of patients with stage IV lung and colorectal cancer, respectively, believed surgery was likely to be curative. On multivariable analyses, the odds ratio (OR) of the perception of curative intent was found to be higher among patients with colorectal versus lung cancer (OR, 2.27). Patients who were female, with an advanced tumor stage, unmarried, and having a higher number of comorbidities were less likely to believe that surgery would cure their cancer; educational level, physical function, and insurance status were not found to be associated with perception of cure. Patients who reported optimal physician communication scores (reference score, 0–80; score of 80–100 [OR, 1.40] and score of 100 [OR, 1.89]) and a shared role in decision-making with their physician (OR, 1.16) or family (OR, 1.17) had a higher odds of perceiving surgery would be curative, whereas patients who reported physician-controlled (OR, 0.56) or family-controlled (OR, 0.72) decision-making were less likely to believe surgery would provide a cure. CONCLUSIONS Greater focus on patient-physician engagement, communication, and barriers to discussing goals of care with patients who are diagnosed with cancer is needed.

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Microwave ablation for non-small cell lung cancer with synchronous solitary extracranial metastasis

Yang

et al. 2020

J Cancer Res Clin Oncol

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Results of a Surgical Resection for Patients With Stage IV Non–Small-Cell Lung Cancer

Cited by 46 publications

References 32 publications

The Role of Thoracic Surgery in the Therapeutic Management of Metastatic Non–Small Cell Lung Cancer

The Role of Thoracic Surgery in the Therapeutic Management of Metastatic Non–Small Cell Lung Cancer

Patient perceptions regarding the likelihood of cure after surgical resection of lung and colorectal cancer

Microwave ablation for non-small cell lung cancer with synchronous solitary extracranial metastasis

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