Results of a phase II pilot study of moderate dose radiotherapy for inoperable desmoid-type fibromatosis—an EORTC STBSG and ROG study (EORTC 62991–22998)

Keus, Ronald B.; Nout, Remi A.; Blay, Jean‐Yves; Jong, Jos M. de; Hennig, I.; Saran, Frank; Hartmann, J.; Sunyach, Marie‐Pierre; Gwyther, Stephen J.; Ouali, M.; Kirkpatrick, A.; Poortmans, P; Hogendoorn, Pancras C.W.; Graaf, Winette T.A. van der

doi:10.1093/annonc/mdt254

Cited by 122 publications

(103 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They reported that the 3 year LC rate was 81.5%. Acute and late side effects were acceptable (27). In our series, the only significant factor for local control was radiotherapy dose.…”

Section: Discussionmentioning

confidence: 50%

“…If there is progression, surgery and/or RT should be the subsequent choice. Therefore, the unnecessary complications of radiotherapy and surgery may be avoided (25)(26)(27). Others have recommended chemotherapy or systemic therapy (such as hormonal therapy, non-steroidal anti-inflammatory therapy or targeted therapy) in patients with advanced unresectable tumors or recurrent disease after surgery and/ or radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Role of Radiotherapy in the Treatment of Primary or Recurrent Desmoid Tumors and Long-Term Results

et al. 2016

View full text Add to dashboard Cite

Background: Desmoid tumors are uncommon and benign mesenchymal neoplasms. The optimal treatment of patients with desmoid tumors is still controversial. Surgery is the primary treatment for locally invasive or recurrent desmoid tumors. Also, radiotherapy is a treatment option for patients at high risk for local failure such as those with positive margins or recurrent and unresectable tumors. Aims: To report our institutional experience and longterm results of patients with desmoid tumors who received radiotherapy. Study Design: Retrospective cross-sectional study. Methods: Between 1980 and 2009, 20 patients who received radiotherapy (RT) in our institution were analyzed. The majority of patients (80%) were referred with a recurrent tumor after previous surgery. Thirteen patients underwent marginal resection, 4 had wide local excision and 3 patients had only biopsy. Resection margin was positive in 15 (75%) patients. All patients received radiation therapy. The median prescribed dose was 60 Gy. Five patients received less than 54 Gy. Results: The median follow-up time was 77.5 months (28-283 months). Nine patients developed local recurrence after RT. Seven local failures (78%) were in field. Time to local recurrence ranged from 3-165 months (median 33 months). The 2-5 year local control (LC) rates were 80% and 69%, respectively. On univariate analysis, the 5 year local control rate was significantly better in the patients treated with ≥54 Gy than in patients who received <54 Gy (p=0.023). The most common acute side effect was grade 1-2 skin toxicity. As a late side effect of radiotherapy, soft tissue fibrosis was detected in 10 patients and lymphangitis was seen in 1 patient. One patient developed radiation-induced sarcoma. Conclusion: According to our results, radiotherapy is especially effective in recurrent disease and provides a high local control rate in the patients received more than 54 Gy.

show abstract

“…They reported that the 3 year LC rate was 81.5%. Acute and late side effects were acceptable (27). In our series, the only significant factor for local control was radiotherapy dose.…”

Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

The Role of Radiotherapy in the Treatment of Primary or Recurrent Desmoid Tumors and Long-Term Results

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The head and neck localization is not common and is mostly sporadic (6) . During 40 years only 179 cases were reported (5) .Parotid localization has been very rarely treated; they have tried to separate it from that arising from other parts of the body (10) , due to its relation to its critical anatomical position (4) . The peak incidence is situating about the third decade (5,6) ; our patient was younger 24 years.…”

Section: Discussionmentioning

confidence: 99%

“…Deep fibromatosis may reach a large size; it generally appears as a mass characterized by being: painless, ill-defined, firm, non-inflammatory, deeply located, fixed to the underlying structures, and which grow slowly (2,4,6) . The natural biological behavior of deep fibromatosis can be unpredictable and variable (10) ; that means that a significant proportion (about 50%) of patients have tumors that remain spontaneously stable after initial progression or even regress and hence benefit from a front line non-aggressive policy (watch and wait) (10) . This spontaneous regression has been observed in the menarche and menopause (5) .…”

Section: Discussionmentioning

confidence: 99%

“…However, radiation therapy is associated with a high risk of complications, especially in the head and neck region, what should be only used in cases of residual disease or where surgery may significantly impair the functional capabilities of the patient (2,6) . Concerning advanced disease with a gross tumor, radiotherapy alone can also be used and leads to tumor control in 70% to 80% of cases, despite the reduction in tumor size may not occur (3,10) . If radiotherapy is contraindicated, chemotherapy is a valid alternative (6) .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Desmoid Tumor of The Parotid Gland

Abir¹,

Monia²,

Abdelkéfi³

et al. 2017

IAM

View full text Add to dashboard Cite

Desmoid tumor is a proliferation of a mesenchymal, fibroblastic or myofibroblastic tissue. It is a non-capsulated tumor. Despite its benign nature, desmoids tumor have an aggressive behavior.Its localization in the parotid gland has rarely been reported in the literature.The particularity of this location in the head and neck is the proximity of Vascularnervous structures, the facial nerve in the parotid location and the consequence, if affected, on the facial motility especially that this tumor often occurs in young people. The clinical presentation is often about a slow-growing mass characterized by being: painless, ill-defined, firm, non-inflammatory, deeply located, and fixed to the underlying structures. Treatments strategies, always made by a multidisciplinary committee, are based on the natural biological behavior of this deep fibromatosis which is unpredictable and variable. Surgery could be undergone every time it is radical. Radiotherapy could also be played. However, the most relevant point is that actually, most authors highlighted the conservative approach by the "wait and see" policy for primary as well as for recurrence of the disease after surgical resection or radiotherapy.

show abstract

Meta-analysis of the influence of surgical margin and adjuvant radiotherapy on local recurrence after resection of sporadic desmoid-type fibromatosis

Janssen

Broekhoven

Cates

et al. 2017

British Journal of Surgery

View full text Add to dashboard Cite

show abstract

Results of a phase II pilot study of moderate dose radiotherapy for inoperable desmoid-type fibromatosis—an EORTC STBSG and ROG study (EORTC 62991–22998)

Abstract: Moderate dose radiotherapy is an effective treatment of patients with DF. Response after radiation therapy is slow with continuing regression seen even after 3 years.

Cited by 122 publications

References 14 publications

The Role of Radiotherapy in the Treatment of Primary or Recurrent Desmoid Tumors and Long-Term Results

The Role of Radiotherapy in the Treatment of Primary or Recurrent Desmoid Tumors and Long-Term Results

Desmoid Tumor of The Parotid Gland

Meta-analysis of the influence of surgical margin and adjuvant radiotherapy on local recurrence after resection of sporadic desmoid-type fibromatosis

Contact Info

Product

Resources

About