Result of awake surgery for pediatric eloquent brain area tumors: single-center experience

Talabaev, M.; Venegas, Kevin; Zabrodets, G. V.; Zmachinskaya, Volha; Antonenko, Alexander; Науменко, Д В; Salauyeva, H.; Churyla, Natalia

doi:10.1007/s00381-020-04666-8

Cited by 6 publications

(19 citation statements)

References 20 publications

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“…Nine studies used resting-state fMRI (rs-fMRI) to evaluate the neuronal changes and alterations resulting from the tumour invasion [ 4 , 8 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. In these studies, the authors discussed the alterations in patients’ working memory [ 32 , 33 ], language [ 8 , 31 ], sensory or motor [ 31 , 36 ], and visual abilities [ 31 , 36 ]. Subsequently, epilepsy and behavioural inhibition that are caused by tumours were also discussed in two papers [ 4 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…Talabaev et al (2020) reported five patients with tumours in speech areas [ 31 ]. Pre-operatively, none of the patients had a speech impairment; however, two patients had mild language and speech disturbance post-operatively.…”

Section: Resultsmentioning

confidence: 99%

“…Pre-operatively, none of the patients had a speech impairment; however, two patients had mild language and speech disturbance post-operatively. The disturbances were resolved within a month of intervention [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…Three studies included sensory or motor changes [ 31 , 36 , 37 ]. Anwar et al (2022) reported patients with tumours at the supratentorial region and two out of twenty-two patients had seizures pre-operatively, localised in the motor area [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

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Functional Alteration in the Brain Due to Tumour Invasion in Paediatric Patients: A Systematic Review

Sahrizan

Manan

Hamid

et al. 2023

Cancers

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Working memory, language and speech abilities, motor skills, and visual abilities are often impaired in children with brain tumours. This is because tumours can invade the brain’s functional areas and cause alterations to the neuronal networks. However, it is unclear what the mechanism of tumour invasion is and how various treatments can cause cognitive impairment. Therefore, this study aims to systematically evaluate the effects of tumour invasion on the cognitive, language, motor, and visual abilities of paediatric patients, as well as discuss the alterations and modifications in neuronal networks and anatomy. The electronic database, PubMed, was used to find relevant studies. The studies were systematically reviewed based on the type and location of brain tumours, cognitive assessment, and pre- and post-operative deficits experienced by patients. Sixteen studies were selected based on the inclusion and exclusion criteria following the guidelines from PRISMA. Most studies agree that tumour invasion in the brain causes cognitive dysfunction and alteration in patients. The effects of a tumour on cognition, language, motor, and visual abilities depend on the type of tumour and its location in the brain. The alteration to the neuronal networks is also dependent on the type and location of the tumour. However, the default mode network (DMN) is the most affected network, regardless of the tumour type and location.Furthermore, our findings suggest that different treatment types can also contribute to patients’ cognitive function to improve or deteriorate. Deficits that persisted or were acquired after surgery could result from surgical manipulation or the progression of the tumour’s growth. Meanwhile, recovery from the deficits indicated that the brain has the ability to recover and reorganise itself.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Functional Alteration in the Brain Due to Tumour Invasion in Paediatric Patients: A Systematic Review

Sahrizan

Manan

Hamid

et al. 2023

Cancers

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“…In children with brain tumors, intraoperative awake mapping is only feasible in a subset of patients aged 8 to 10 years and older, mostly because of anesthesia issues and patients' collaboration, but also because of lower ex- citability of the incompletely myelinated brain by direct electrical stimulation. 30,31 Intraoperative Monitoring While all other functions require an awake and responsive patient for monitoring, motor function can be monitored continuously via MEPs by a strip electrode directly placed onto the primary motor cortex and an additional needle electrode at Fpz as the cathodic pole or via transcranial electrical stimulation at C3 and C4 as determined by the 10-20 EEG system. Any decline in amplitude < 50% of the baseline is considered significant if technical problems or anesthesia reasons have been ruled out.…”

Section: Intraoperative Mappingmentioning

confidence: 99%

Neurosurgery for eloquent lesions in children: state-of-the-art rationale and technical implications of perioperative neurophysiology

Krieg

Bernhard

Ille

et al. 2022

Neurosurgical Focus

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OBJECTIVE In adult patients, an increasing group of neurosurgeons specialize entirely in the treatment of highly eloquent tumors, particularly gliomas. In contrast, extensive perioperative neurophysiological workup for pediatric cases has been limited essentially to epilepsy surgery. METHODS The authors discuss radio-oncological and general oncological considerations based on the current literature and their personal experience. RESULTS While several functional mapping modalities facilitate preoperative identification of cortically and subcortically located eloquent areas, not all are suited for children. Direct cortical intraoperative stimulation is impractical in many young patients due to the reduced excitability of the immature cortex. Behavioral requirements also limit the utility of functional MRI and magnetoencephalography in children. In contrast, MRI-derived tractography and navigated transcranial magnetic stimulation are available across ages. Herein, the authors review the oncological rationale of function-guided resection in pediatric gliomas including technical implications such as personalized perioperative neurophysiology, surgical strategies, and limitations. CONCLUSIONS Taken together, these techniques, despite the limitations of some, facilitate the identification of eloquent areas prior to tumor surgery and radiotherapy as well as during follow-up of residual tumors.

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Patients with Barriers of Communication

Krieg

Ille

Delion

2021

Intraoperative Mapping of Cognitive Networks

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Result of awake surgery for pediatric eloquent brain area tumors: single-center experience

Cited by 6 publications

References 20 publications

Functional Alteration in the Brain Due to Tumour Invasion in Paediatric Patients: A Systematic Review

Functional Alteration in the Brain Due to Tumour Invasion in Paediatric Patients: A Systematic Review

Neurosurgery for eloquent lesions in children: state-of-the-art rationale and technical implications of perioperative neurophysiology

Patients with Barriers of Communication

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