Restoration of Foveal Anatomy and Function Following Chemoreduction for Bilateral Advanced Retinoblastoma With Total Retinal Detachment

Review of optical coherence tomography for intraocular tumors

“…Causes for visual loss include retinal atrophy, retinal edema, persistent retinal detachment, optic disk edema or atrophy, macular tumor scar, cataract, corneal dryness and scarring, and amblyopia. In some instances, eyes with total retinal detachment from retinoblastoma have recovered complete function of the retina both clinically and anatomically, confirmed on OCT [45] (Fig. 16).…”

Review of optical coherence tomography for intraocular tumors

“…Causes for visual loss include retinal atrophy, retinal edema, persistent retinal detachment, optic disk edema or atrophy, macular tumor scar, cataract, corneal dryness and scarring, and amblyopia. In some instances, eyes with total retinal detachment from retinoblastoma have recovered complete function of the retina both clinically and anatomically, confirmed on OCT [45] (Fig. 16).…”

Effect of Intraarterial Chemotherapy on Retinoblastoma-Induced Retinal Detachment

“…14 In one case report, retinoblastoma-related bilateral total retinal detachment resolved in a young child treated with chemoreduction, leaving a visual acuity of 20/50 and 20/70. 5 Further analysis of visual acuity results at 5 years after successful chemoreduction for 54 eyes with retinoblastoma disclosed visual acuity of 20/20 to 20/40 in 50% of cases and 20/ 200 or better in 67%. 15 Multivariate analysis revealed subretinal fluid in the fovea to have a negative impact on achieving 20/40 or better vision but no statistical impact on visual acuity of 20/200 or better.…”

“…[1][2][3] With advances in chemotherapy, three-drug intravenous chemoreduction using vincristine, etoposide, and carboplatin has been shown effective for retinoblastoma control 4 and successful in bringing about resolution of tumorrelated retinal detachment. 5,6 In fact, complete resolution of retinoblastoma-related total retinal detachment was found in 76% eyes after chemoreduction. 6 In more recent years, some interest has focused on localized intraarterial chemotherapy (IAC) (ophthalmic artery) in an effort to control the tumor and avoid systemic toxicities.…”

Retinoblastoma, the visible CNS tumor: A review

“…Recently, with the advent of handheld intraoperative OCT systems, OCT has become popular for pediatric ophthalmology as well, including retinoblastoma assessment (Do, Do, & Berry, 2017). Initial publications were case reports indicating the value of OCT for detecting cavitary retinoblastoma (Mashayekhi, Shields, Eagle, & Shields, 2005) and reasons for visual loss (such as retinal detachment) post therapy (Shields, Materin, & Shields, 2005). Subsequently, OCT showed utility for documenting response to therapy, spotting edge recurrence, and, notably, detecting "invisible" tiny retinoblastoma (Figure 3d-f) (Rootman et al, 2013), as well as assessing foveal anatomy, which impacts the likelihood of visual function post therapy (Cao, Markovitz, Ferenczy, & Shields, 2014;Samara, Pointdujour-Lim, Say, & Shields, 2015).…”

Review of optical coherence tomography for intraocular tumors

“…Causes for visual loss include retinal atrophy, retinal edema, persistent retinal detachment, optic disk edema or atrophy, macular tumor scar, cataract, corneal dryness and scarring, and amblyopia. In some instances, eyes with total retinal detachment from retinoblastoma have recovered complete function of the retina both clinically and anatomically, confirmed on OCT [45] (Fig. 16).…”

Effect of Intraarterial Chemotherapy on Retinoblastoma-Induced Retinal Detachment

“…14 In one case report, retinoblastoma-related bilateral total retinal detachment resolved in a young child treated with chemoreduction, leaving a visual acuity of 20/50 and 20/70. 5 Further analysis of visual acuity results at 5 years after successful chemoreduction for 54 eyes with retinoblastoma disclosed visual acuity of 20/20 to 20/40 in 50% of cases and 20/ 200 or better in 67%. 15 Multivariate analysis revealed subretinal fluid in the fovea to have a negative impact on achieving 20/40 or better vision but no statistical impact on visual acuity of 20/200 or better.…”

“…[1][2][3] With advances in chemotherapy, three-drug intravenous chemoreduction using vincristine, etoposide, and carboplatin has been shown effective for retinoblastoma control 4 and successful in bringing about resolution of tumorrelated retinal detachment. 5,6 In fact, complete resolution of retinoblastoma-related total retinal detachment was found in 76% eyes after chemoreduction. 6 In more recent years, some interest has focused on localized intraarterial chemotherapy (IAC) (ophthalmic artery) in an effort to control the tumor and avoid systemic toxicities.…”

Retinoblastoma, the visible CNS tumor: A review

“…Recently, with the advent of handheld intraoperative OCT systems, OCT has become popular for pediatric ophthalmology as well, including retinoblastoma assessment (Do, Do, & Berry, 2017). Initial publications were case reports indicating the value of OCT for detecting cavitary retinoblastoma (Mashayekhi, Shields, Eagle, & Shields, 2005) and reasons for visual loss (such as retinal detachment) post therapy (Shields, Materin, & Shields, 2005). Subsequently, OCT showed utility for documenting response to therapy, spotting edge recurrence, and, notably, detecting "invisible" tiny retinoblastoma (Figure 3d-f) (Rootman et al, 2013), as well as assessing foveal anatomy, which impacts the likelihood of visual function post therapy (Cao, Markovitz, Ferenczy, & Shields, 2014;Samara, Pointdujour-Lim, Say, & Shields, 2015).…”

Review of optical coherence tomography for intraocular tumors

“…Causes for visual loss include retinal atrophy, retinal edema, persistent retinal detachment, optic disk edema or atrophy, macular tumor scar, cataract, corneal dryness and scarring, and amblyopia. In some instances, eyes with total retinal detachment from retinoblastoma have recovered complete function of the retina both clinically and anatomically, confirmed on OCT [45] (Fig. 16).…”

Effect of Intraarterial Chemotherapy on Retinoblastoma-Induced Retinal Detachment

“…14 In one case report, retinoblastoma-related bilateral total retinal detachment resolved in a young child treated with chemoreduction, leaving a visual acuity of 20/50 and 20/70. 5 Further analysis of visual acuity results at 5 years after successful chemoreduction for 54 eyes with retinoblastoma disclosed visual acuity of 20/20 to 20/40 in 50% of cases and 20/ 200 or better in 67%. 15 Multivariate analysis revealed subretinal fluid in the fovea to have a negative impact on achieving 20/40 or better vision but no statistical impact on visual acuity of 20/200 or better.…”

“…[1][2][3] With advances in chemotherapy, three-drug intravenous chemoreduction using vincristine, etoposide, and carboplatin has been shown effective for retinoblastoma control 4 and successful in bringing about resolution of tumorrelated retinal detachment. 5,6 In fact, complete resolution of retinoblastoma-related total retinal detachment was found in 76% eyes after chemoreduction. 6 In more recent years, some interest has focused on localized intraarterial chemotherapy (IAC) (ophthalmic artery) in an effort to control the tumor and avoid systemic toxicities.…”

Retinoblastoma, the visible CNS tumor: A review

“…Recently, with the advent of handheld intraoperative OCT systems, OCT has become popular for pediatric ophthalmology as well, including retinoblastoma assessment (Do, Do, & Berry, 2017). Initial publications were case reports indicating the value of OCT for detecting cavitary retinoblastoma (Mashayekhi, Shields, Eagle, & Shields, 2005) and reasons for visual loss (such as retinal detachment) post therapy (Shields, Materin, & Shields, 2005). Subsequently, OCT showed utility for documenting response to therapy, spotting edge recurrence, and, notably, detecting "invisible" tiny retinoblastoma (Figure 3d-f) (Rootman et al, 2013), as well as assessing foveal anatomy, which impacts the likelihood of visual function post therapy (Cao, Markovitz, Ferenczy, & Shields, 2014;Samara, Pointdujour-Lim, Say, & Shields, 2015).…”