Resting-State Functional Correlates of Social Cognition in Multiple Sclerosis: An Explorative Study

Bisecco, Alvino; Altieri, Manuela; Santangelo, Gabriella; Nardo, Federica Di; Docimo, Renato; Caiazzo, Giuseppina; Capuano, Rocco; Pappacena, Simona; d’Ambrosio, Alessandro; Bonavita, Simona; Trojsi, Francesca; Cirillo, Mario; Esposito, Fabrizio; Tedeschi, Gioacchino; Gallo, Antonio

doi:10.3389/fnbeh.2019.00276

Cited by 19 publications

(32 citation statements)

References 73 publications

(84 reference statements)

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“…Trim and fill: look for missing studies to left of mean, using random effects model. Imputed mean is random effects.suggested that the domains of cognitive and affective ToM are dissociated, and the function of cognitive empathy/affective ToM in MS is conserved, but cognitive ToM is impaired(74,85,88,93). However, findings from the current quantitative metaanalysis do not support this suggestion, which showed that patients of MS had moderate impairment in both cognitive and affective ToM and their degrees of defect were close (g = −0.72 and g = −0.79, respectively).…”

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confidence: 99%

“…Several studies based on magnetic resonance imaging (MRI) have found that amygdala atrophy is the main predictor of ToM impairment in MS(66,72). Besides, one resting-state functional MRI study found that there was an association between ToM impairment and functional connectivity changes in the default mode network, executive network, and limbic network in MS(74).…”

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confidence: 99%

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Empathy and Theory of Mind in Multiple Sclerosis: A Meta-Analysis

et al. 2021

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Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system. Studies have shown that MS disrupts several social cognitive abilities [including empathy and theory of mind (ToM)]. Overall ToM deficits in MS are well documented, but how the specific ToM subcomponents and empathic capacity are affected remains unclear. For this meta-analysis, we searched PubMed, Web of Science, and Embase from inception to July 2020. Effect sizes were calculated using Hedges g with a random-effects model. Thirty-three studies were included. Relative to healthy controls (HCs), patients with MS were moderately impaired in overall empathy (g = −0.67), overall ToM (g = −74), cognitive ToM (g = −0.72), and the overlapping domains of cognitive empathy/affective ToM (g = −0.79); no group differences were identified for affective empathy (g = −0.19). Compared with HCs, patients with relapsing-remitting MS (RRMS) and progressive MS were impaired in overall empathy, overall ToM, cognitive ToM, and cognitive empathy/affective ToM, without significant RRMS–progressive MS differences in impairment degree. We conducted the first meta-analytic review investigating the empathy and ToM functioning patterns in patients with MS and examined the overlapping and distinct subcomponents of these constructs. The findings suggest differential impairment of the core aspects of social cognitive processing in patients with MS, which may importantly inform the development of structured social cognitive MS interventions.

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confidence: 99%

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confidence: 99%

Empathy and Theory of Mind in Multiple Sclerosis: A Meta-Analysis

et al. 2021

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Section: Introductionmentioning

confidence: 99%

“…A few studies used functional MRI (fMRI) to investigate SC in MS (Bisecco et al, 2020; Golde et al., 2020; Jehna et al., 2011; Krause et al., 2009; Labbe et al., 2020; Passamonti et al., 2009). Only one used resting‐state fMRI (rfMRI) combined with RMET (Bisecco et al, 2020) and found no correlation between the functional connectivity (FC) and performances in the test (Bisecco et al, 2020). However, the performances of patients with MS in the Faux Pas (FP) test, a test of affective and cognitive ToM, were correlated with FC between the right amygdala and the left inferior occipital and visual lateral cortices and with FC between the left cerebellum, the right occipital and visual lateral cortices, and the lingual gyrus (Labbe et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Amygdala network reorganization mediates the theory of mind performances in multiple sclerosis

Koubiyr

Dulau‐Metras

Deloire

et al. 2021

J of Neuroscience Research

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Theory of mind (ToM) seems to be affected in multiple sclerosis (MS). MRI studies suggested a role of the amygdala in social cognitive performances. Therefore, we explored the role of the amygdala network in ToM using a multimodal MRI approach. In MS, patients with impaired ToM showed contradictory dysexecutive neuropsychological profile. Therefore, we compared neural networks involved in ToM and executive functions (EFs). Twenty patients with relapsing‐remitting MS and 15 matched healthy controls were selected. ToM (Faux Pas test and mind stories) and EFs were assessed within and outside the scanner. All subjects underwent a battery of neuropsychological tests. Multimodal MRI with structural (diffusion imaging) and functional (resting‐state and task‐based) sequences was used to analyze the role and connections of the amygdala in ToM functioning. Cognitive and ToM performances were similar between patients and controls. Resting‐state data revealed decreased connectivity of the left amygdala with frontal areas in patients compared to controls (p < 0.0001). During the task‐based functional MRI, patients demonstrated increased connectivity between the amygdala and several cerebellar and left temporal regions (all p < 0.05). The microstructural alterations between the left amygdala and left temporal regions were associated with increased functional connectivity within the same pathway (r = 0.74; p < 0.01). No overlap was observed between functional networks involved in ToM and EFs. Our study demonstrates more connectivity recruitment between the amygdala and cerebellar and temporal regions in MS patients to reach preserved ToM performance. Microstructural abnormalities have been related to this compensatory network. Finally, different networks were involved in EFs and ToM.

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“…It can assessment the synchronization and the interactions among multiple networks, thus overcomes the shortcomings of timedependent analysis 17 . Its reliability and validity have been verified in the study of a series of cognitive disorders [18][19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

Dysconnectivity between auditory-cognitive network associated with auditory GABA and glutamate levels in presbycusis patients

Ren

et al. 2021

Preprint

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Accumulating studies suggest an interaction between presbycusis (PC) and cognitive impairment, which may be explained by the cognitive-ear link to a large extent. However, the neurophysiological mechanisms underlying this link are largely unknown. Here, 51 PC patients and 51 well-matched healthy controls were recruited. We combined resting-state functional MRI and edited magnetic resonance spectroscopy to investigate changes of intra- and inter-network functional connectivity and their relationships with auditory gamma-aminobutyric acid (GABA) and glutamate (Glu) levels and cognitive impairment in PC. Our study confirmed the plastic model of cognitive-ear link at the level of the large-scale brain network, including the dysconnectivity within high-order cognitive networks and between the auditory-cognitive network and overactivation between cognitive networks dependent on hearing loss, which was closely related to the cognitive impairment of PC patients. Moreover, GABA and Glu levels in the central auditory processing were abnormal in patients with PC. Importantly, reduction of GABA-mediated inhibition plays a crucial role in a dysconnectivity between the auditory-cognitive network, which may be neurochemical underpinnings of functional remodeling of cognitive-ear link in PC. Modulation of GABA neurotransmission may enable the development of new therapeutic strategies for the cognitive impairment of PC patients.

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Resting-State Functional Correlates of Social Cognition in Multiple Sclerosis: An Explorative Study

Cited by 19 publications

References 73 publications

Empathy and Theory of Mind in Multiple Sclerosis: A Meta-Analysis

Empathy and Theory of Mind in Multiple Sclerosis: A Meta-Analysis

Amygdala network reorganization mediates the theory of mind performances in multiple sclerosis

Dysconnectivity between auditory-cognitive network associated with auditory GABA and glutamate levels in presbycusis patients

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