Resting-state functional connectivity of the amygdala in suicide attempters with major depressive disorder

Kang, Seung-Gul; Lee, Jin-Seong; Choi, Jae Won; Kim, Jeong Hee; Son, Young-Don; Lee, Yu Jin

doi:10.1016/j.pnpbp.2017.04.029

Cited by 94 publications

(72 citation statements)

References 43 publications

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“…Using task fMRI, lower amygdala-VMPFC/rostral PFC connectivity was found in adolescent and young adult SAs with BD while viewing happy and neutral facial expression, and associated with higher lethality of attempts and current SI [35]. During rest, greater amygdala connectivity with lateral OFC, insula, and middle temporal gyrus was found in adult SAs with MDD, with greater amygdala-parahippocampus connectivity associated with SI [159]. These functional connectivity alterations are in line with lower FA in the uncinate fasciculus, which provides major amygdala connections, in adolescents SAs with BD [35].…”

Section: Structural and Functional Connectivitymentioning

confidence: 95%

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

et al. 2019

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Identifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are important to develop more targeted and effective strategies to prevent suicide. In the last decade, and especially in the last 5 years, there has been exponential growth in the number of neuroimaging studies reporting structural and functional brain circuitry correlates of STBs. Within this narrative review, we conducted a comprehensive review of neuroimaging studies of STBs published to date and summarize the progress achieved on elucidating neurobiological substrates of STBs, with a focus on converging findings across studies. We review neuroimaging evidence across differing mental disorders for structural, functional, and molecular alterations in association with STBs, which converges particularly in regions of brain systems that subserve emotion and impulse regulation including the ventral prefrontal cortex (VPFC) and dorsal PFC (DPFC), insula and their mesial temporal, striatal and posterior connection sites, as well as in the connections between these brain areas. The reviewed literature suggests that impairments in medial and lateral VPFC regions and their connections may be important in the excessive negative and blunted positive internal states that can stimulate suicidal ideation, and that impairments in a DPFC and inferior frontal gyrus (IFG) system may be important in suicide attempt behaviors. A combination of VPFC and DPFC system disturbances may lead to very high risk circumstances in which suicidal ideation is converted to lethal actions via decreased top-down inhibition of behavior and/or maladaptive, inflexible decision-making and planning. The dorsal anterior cingulate cortex and insula may play important roles in switching between these VPFC and DPFC systems, which may contribute to the transition from suicide thoughts to behaviors. Future neuroimaging research of larger sample sizes, including global efforts, longitudinal designs, and careful consideration of developmental stages, and sex and gender, will facilitate more effectively targeted preventions and interventions to reduce loss of life to suicide.

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Section: Structural and Functional Connectivitymentioning

confidence: 95%

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

et al. 2019

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“…It focused on RSFC alterations of the amygdala and compared 19 suicidal (SUIC) major depressive disorder (MDD) to 19 non‐suicidal (NS) MDD patients. They found increased RSFC from the left amygdala to the right insula and left superior OFC, and from the right amygdala to left middle temporal area in SUIC‐MDD .…”

Section: Introductionmentioning

confidence: 98%

Classifying suicidal behavior with resting‐state functional connectivity and structural neuroimaging

Gosnell

Fowler

Salas

2019

Acta Psychiatr Scand

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R. Classifying suicidal behavior with resting-state functional connectivity and structural neuroimaging Objective: About 80% of patients who commit suicide do not report suicidal ideation the last time they speak to their mental health provider, highlighting the need to identify biomarkers of suicidal behavior. Our goal is to identify suicidal behavior neural biomarkers to classify suicidal psychiatric inpatients. Methods: Eighty percent of our sample [suicidal (n = 63) and nonsuicidal psychiatric inpatients (n = 65)] was used to determine significant differences in structural and resting-state functional connectivity measures throughout the brain. These measures were used in a random forest classification model on 80% of the sample for training the model. Results: The model built on 80% of the patients had sensitivity = 79.4% and specificity = 72.3%. This model was tested on an independent sample (20%; n = 32) with sensitivity = 81.3% and specificity = 75.0% for confirming the generalizability of the model. Altered resting-state functional connectivity features from frontal and middle temporal regions, as well as the amygdala, parahippocampus, putamen, and vermis were found to generalize best. Conclusion: This work demonstrates neuroimaging (an unbiased biomarker) can be used to classify suicidal behavior in psychiatric inpatients without observing any clinical features. Summations• Neural biomarkers can be used to reliably classify suicidal behavior/ideation. • Resting-state functional connectivity of frontal and middle temporal regions, as well as the amygdala, parahippocampus, putamen, and vermis are altered in suicidal psychiatric patients compared to nonsuicidal patients.• The identification of neural biomarkers for classifying suicide may benefit assessment of suicidal risk in the future. Limitations• Neural biomarkers can only be said to be correlative with suicidal behavior, not causative. • While this work successfully classifies patients as suicidal or not, classification is not necessarily prediction.

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“…More recent studies have found adults with MDD, and suicidality show decreased RSFC between the rostral ACC, orbitomedial PFC, and right middle temporal pole compared to those without suicidal ideation and healthy controls (Du et al., ). Also, adults with MDD and suicide attempts show increased RSFC between the left amygdala and right insula and left orbitofrontal area and between the right amygdala and left middle temporal area compared to those without suicide attempts (Kang et al., ). These findings provide further evidence for aberrancies in affective experience and regulation.…”

mentioning

confidence: 99%

Neural Correlates of Suicidality in Adolescents with Major Depression: Resting‐State Functional Connectivity of the Precuneus and Posterior Cingulate Cortex

Schreiner

Klimes‐Dougan

Cullen

2018

Suicide & Life Threat Behav

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Resting-state functional connectivity of the amygdala in suicide attempters with major depressive disorder

Cited by 94 publications

References 43 publications

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

Classifying suicidal behavior with resting‐state functional connectivity and structural neuroimaging

Neural Correlates of Suicidality in Adolescents with Major Depression: Resting‐State Functional Connectivity of the Precuneus and Posterior Cingulate Cortex

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