Resting‐state fMRI and social cognition: An opportunity to connect

Doruyter, Alexander; Groenewold, Nynke A.; Dupont, Patrick; Stein, Dan J.; Warwick, James

doi:10.1002/hup.2627

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…In humans, focal brain lesions and social task-based fMRI studies have largely contributed to identifying a network of brain regions (called “the social brain”) implicated in social cognition [ 33 , 34 , 35 , 36 , 37 ]. The primary regions of the social brain include the medial prefrontal cortex (mPFC) [ 38 , 39 ], the temporoparietal junction (TPJ), the posterior superior temporal sulcus (pSTS), the inferior frontal gyrus, the anterior cingulate cortex (ACC) [ 40 ], and the anterior insula (AI) [ 41 ] ( Figure 1 ).…”

Section: Neural Bases For Impaired Social Cognition In Asdmentioning

confidence: 99%

The Cerebellar Involvement in Autism Spectrum Disorders: From the Social Brain to Mouse Models

D’Angelo

Mapelli

soda

et al. 2022

IJMS

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Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders that include a variety of forms and clinical phenotypes. This heterogeneity complicates the clinical and experimental approaches to ASD etiology and pathophysiology. To date, a unifying theory of these diseases is still missing. Nevertheless, the intense work of researchers and clinicians in the last decades has identified some ASD hallmarks and the primary brain areas involved. Not surprisingly, the areas that are part of the so-called “social brain”, and those strictly connected to them, were found to be crucial, such as the prefrontal cortex, amygdala, hippocampus, limbic system, and dopaminergic pathways. With the recent acknowledgment of the cerebellar contribution to cognitive functions and the social brain, its involvement in ASD has become unmistakable, though its extent is still to be elucidated. In most cases, significant advances were made possible by recent technological developments in structural/functional assessment of the human brain and by using mouse models of ASD. Mouse models are an invaluable tool to get insights into the molecular and cellular counterparts of the disease, acting on the specific genetic background generating ASD-like phenotype. Given the multifaceted nature of ASD and related studies, it is often difficult to navigate the literature and limit the huge content to specific questions. This review fulfills the need for an organized, clear, and state-of-the-art perspective on cerebellar involvement in ASD, from its connections to the social brain areas (which are the primary sites of ASD impairments) to the use of monogenic mouse models.

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Section: Neural Bases For Impaired Social Cognition In Asdmentioning

confidence: 99%

The Cerebellar Involvement in Autism Spectrum Disorders: From the Social Brain to Mouse Models

D’Angelo

Mapelli

soda

et al. 2022

IJMS

View full text Add to dashboard Cite

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“…brain areas (e.g., networks) are critical to social cognitive abilities (Lieberman, 2007). Functional connectivity analysis of resting-state functional magnetic resonance imaging (rsfMRI) offers insight into the intrinsic activity of these networks, and allows for examination of their relationship to social cognitive performance (Doruyter, Dupont, Stein, & Warwick, 2017). Substantial work has examined regional activation and, more recently, functional connectivity, associated with social cognitive processes in healthy adults, mostly utilizing task-based fMRI.…”

mentioning

confidence: 99%

Linking resting‐state networks and social cognition in schizophrenia and bipolar disorder

Jimenez

Riedel

Lee

et al. 2019

Human Brain Mapping

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Individuals with schizophrenia and bipolar disorder show alterations in functional neural connectivity during rest. However, resting‐state network (RSN) disruptions have not been systematically compared between the two disorders. Further, the impact of RSN disruptions on social cognition, a key determinant of functional outcome, has not been studied. Forty‐eight individuals with schizophrenia, 46 with bipolar disorder, and 48 healthy controls completed resting‐state functional magnetic resonance imaging. An atlas‐based approach was used to examine functional connectivity within nine RSNs across the cortex. RSN connectivity was assessed via nonparametric permutation testing, and associations with performance on emotion perception, mentalizing, and emotion management tasks were examined. Group differences were observed in the medial and lateral visual networks and the sensorimotor network. Individuals with schizophrenia demonstrated reduced connectivity relative to healthy controls in all three networks. Individuals with bipolar disorder demonstrated reduced connectivity relative to controls in the medial visual network and connectivity within this network was significantly positively correlated with emotion management. In healthy controls, connectivity within the medial and lateral visual networks positively correlated with mentalizing. No significant correlations were found for either visual network in schizophrenia. Results highlight the role of altered early visual processing in social cognitive deficits in both schizophrenia and bipolar disorder. However, individuals with bipolar disorder appear to compensate for disrupted visual network connectivity on social cognitive tasks, whereas those with schizophrenia do not. The current study adds clarity on the neurophysiology underlying social cognitive deficits that result in impaired functioning in serious mental illness.

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“…The passed 2 decades have witnessed that advanced MRI modalities including functional magnetic resonance imaging (fMRI), structural magnetic resonance imaging (sMRI) and diffusional kurtosis imaging (DKI) techniques have been extensively utilized in the study of cognitive impairment [11][12][13].…”

mentioning

confidence: 99%

Brain structural and functional changes in asymptomatic chronic internal carotid artery occlusion: protocol for a multi-modal MRI trial

Zhang

et al. 2023

Preprint

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Background: Whether asymptomatic chronicinternal carotid artery occlusion (CICAO) can cause cognitive impairment as well as its underlying neuroimaging alterations remain controversial. Multi-modal magnetic resonance imaging (MRI) has been extensively utilized in the study of cognitive impairment to reveal the potential brain functional or structural changes. We aim to investigate the underlying brain changes in asymptomatic CICAO patients with or without cognitive impairment by using multimodal MRI techniques. Methods: First, patients with asymptomatic CICAO will be recruited from Tangdu hospital, and individuals without CICAO will be recruited as health controls (HC) from the local community. Then, these subjects will undergo a series of neuropsychology tests focusing on the cognition and multi-modal MRI brain scans. Appropriate statistical software will be utilized to investigate the neuropsychological performance and multimodal MRI data to investigate the potential associations between cognition and the neuroimaging features in patients with asymptomatic CICAO. Discussion: In this study, multi-modal MRI will be used to evaluate the characteristics of asymptomatic CICAO. Imaging features that will be assessed include volumetric characteristics, functional characteristics and perfusion properties. Clinical information, such as basic information, age, gender, body mass index and educational level for asymptomatic CICAO will be collected for statistical analysis. Montreal Cognitive Assessment, Pittsburgh Sleep Quality Index, Self-rating Depression Scale and Self-rating Anxiety Scale will be applied to access cognition, sleep disorder, depression and anxiety, respectively. This clinical trial will help establish an effective screening system to assess cognitive impairment and the underlying neuroimaging biomarkers for asymptomatic CICAO disease. Trial registration: This study has already been registered at Clinical Trials. Gov (ID: NCT04443439) on May 27, 2020.

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Resting‐state fMRI and social cognition: An opportunity to connect

Cited by 5 publications

References 34 publications

The Cerebellar Involvement in Autism Spectrum Disorders: From the Social Brain to Mouse Models

The Cerebellar Involvement in Autism Spectrum Disorders: From the Social Brain to Mouse Models

Linking resting‐state networks and social cognition in schizophrenia and bipolar disorder

Brain structural and functional changes in asymptomatic chronic internal carotid artery occlusion: protocol for a multi-modal MRI trial

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