Resting-State Connectivity Predictors of Response to Psychotherapy in Major Depressive Disorder

Crowther, Andrew; Smoski, Moria J.; Minkel, Jared; Moore, Tyler M.; Gibbs, Devin; Petty, Chris; Bizzell, Joshua; Schiller, Crystal Edler; Sideris, John; Carl, Hannah; Dichter, Gabriel S.

doi:10.1038/npp.2015.12

Cited by 117 publications

(70 citation statements)

References 141 publications

(147 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specifically, behavioral activation therapy was followed by activation changes in the paracingulate gyrus during reward selection, the right caudate nucleus during reward anticipation, and the paracingulate and orbital frontal gyri during reward feedback (Dichter et al, 2009; Dichter et al, 2010). Response of major depression to behavioral activation was predicted by pretreatment connectivity of the right insula with the right middle temporal gyrus and the left intraparietal sulcus with the orbital frontal cortex (Crowther et al, 2015). …”

Section: Discussionmentioning

confidence: 99%

“Engage” therapy: Prediction of change of late-life major depression

Alexopoulos

O’Neil

Banerjee

et al. 2017

Journal of Affective Disorders

View full text Add to dashboard Cite

Objective Engage grew out of the need for streamlined psychotherapies that can be accurately used by community therapists in late-life depression. Engage was based on the view that dysfunction of reward networks is the principal mechanism mediating depressive symptoms. Accordingly, Engage uses “reward exposure” (exposure to meaningful activities) and assumes that repeated activation of reward networks will normalize these systems. This study examined whether change in a behavioral activation scale, an index of reward system function, predicts change in depressive symptomatology. Methods The participants (N=48) were older adults with major depression treated with 9 weekly sessions of Engage and assessed 27 weeks after treatment. Depression was assessed with the 24-item Hamilton Depression Rating Scale (HAM-D) and behavioral activation with the four subscales of Behavioral Activation for Depression Scale (activation, avoidance/rumination, work impairment, social impairment) at baseline, 6 weeks (mid-treatment), 9 weeks (end of treatment), and 36 weeks. Results Change only in the Activation subscale during successive periods of assessment predicted depression severity (HAM-D) at the end of each period (F1,47=21.05, p<0.0001). An increase of one standard deviation in the Activation score resulted in a 2.04 (95% CI: 1.17–2.92) point decrease in HAM-D. For every one point increase in the Activation score, HAM-D was decreased by 0.22 points (95% CI: 0.12–0.31). Limitations No comparison group. Partial overlap of Activation Subscale with HAM-D, lack of detailed neurocognitive assessment and social support. Conclusion Change in behavioral activation predicts improvement of depressive symptoms and signs in depressed older adults treated with Engage.

show abstract

Section: Discussionmentioning

confidence: 99%

“Engage” therapy: Prediction of change of late-life major depression

Alexopoulos

O’Neil

Banerjee

et al. 2017

Journal of Affective Disorders

View full text Add to dashboard Cite

show abstract

“…Response of major depression to behavioral activation was predicted by pretreatment connectivity of the right insula with the right middle temporal gyrus and the left intraparietal sulcus with the orbital frontal cortex. (29) Behavioral activation therapy was followed by activation changes in reward structures, including the paracingulate gyrus during reward selection, the right caudate nucleus during reward anticipation, and the paracingulate and orbital frontal gyri during reward feedback. (30) A paradigm requiring cognitive control in both sad and neutral contexts resulted in decreased activation in prefrontal structures (paracingulate gyrus, the right orbital frontal cortex, and the right frontal pole) during responses to cognitive control stimuli presented within a sad context in prefrontal structures.…”

Section: Discussionmentioning

confidence: 99%

“Engage” Therapy: Behavioral Activation and Improvement of Late-Life Major Depression

Alexopoulos

Raue

Gunning

et al. 2016

The American Journal of Geriatric Psychiatry

View full text Add to dashboard Cite

Objective Engage is a treatment for late-life depression developed to match the skills of community clinicians. It is based on the theory that dysfunction in the RDoC positive valence systems (PVS) is a critical mechanism of late life depression. Accordingly, it uses “reward exposure” (engagement in meaningful, rewarding activities) as its principal intervention. This study tests the hypothesis that change in behavioral activation, an index of PVS function, during successive treatment periods with Engage and during follow-up predicts depression at the end of each period. Methods Forty-eight non-demented, older adults with unipolar major depression were treated openly with 9 weekly sessions of Engage and assessed 36 weeks after entry. Depression severity was assessed with the 24-item Hamilton Depression Rating Scale (HAM-D) and behavioral activation with the Behavioral Activation for Depression Scale (BAS) at baseline, 6 weeks (mid-treatment), 9 weeks (end of treatment), and 36 weeks. Results A mixed effects model examined whether change in BAS in successive periods occurring during Engage treatment and during follow-up predicts depression at the end of each period. Both BAS change (F1, 52=18.63, p<0.0001) and time (F2, 52=7.68, p=0.0012) predicted HAM-D scores at the end of each observation period. For every point of increase in BAS change, there was a reduction of HAM-D by 0.105 points. HAM-D at each point did not predict subsequent change in BAS (F1, 52=2.17, p = 0.146). Conclusion During Engage treatment and follow-up, change in behavioral activation is followed by improvement of depressive symptoms and signs.

show abstract

“…Importantly, individual differences in these circuits at baseline are predictive of medication response [7]. For example, in patients with major depression, greater connectivity from insula at baseline was predictive of response to cognitive behavioral therapy [69]. …”

Section: Cognitive Control Circuitry Is Frequently Enhanced By Psychimentioning

confidence: 99%

The ABCD Study of Neurodevelopment: Identifying Neurocircuit Targets for Prevention and Treatment of Adolescent Substance Abuse

Bjork

Straub

Provost

et al. 2017

Curr Treat Options Psych

View full text Add to dashboard Cite

OPINION STATEMENT Substance use disorders (SUD) can be considered developmental disorders in light of their frequent origins in substance initiation during adolescence. Cross-sectional functional magnetic resonance imaging (fMRI) studies of adolescent substance users or adolescents with SUD have indicated aberrations in brain structures or circuits implicated in motivation, self-control, and mood-regulation. However, attributing these differences to the neurotoxicological effects of chronic substance use has been problematic in that these circuits are also aberrant in at-risk children, such as those with prenatal substance exposure, externalizing disorders (such as conduct disorder), or prodromal internalizing disorders such as depression. To better isolate the effects of substance exposure on the adolescent brain, the newly-launched Adolescent Brain Cognitive Development (ABCD) study, funded by the National Institutes of Health, will follow the neurodevelopmental trajectories of over 11,000 American 9/10-year-olds for 10 years, into emerging adulthood. This study will provide a rich open-access dataset on longitudinal interactions of neurodevelopment, environmental exposures, and childhood psychopathology that confer addiction risk. The ABCD twin study will further clarify genetic versus experiential influences (e.g., substance use) on neurodevelopmental and psychosocial outcomes. Neurocircuitry thought to regulate mood and behavior has been directly normalized by administration of psychoactive medications and by cognitive therapies in adults. Because of this, we contend that ABCD project data will be a crucial resource for prevention and treatment of SUD in adolescence because its cutting-edge neuroimaging and childhood assessments hold potential for discovery of additional targetable brain differences earlier in development that are prognostic of (or aberrant in) SUD. The ABCD sample size will also have the power to illuminate how sex differences, environmental interactions and other individual differences interact with neurodevelopment to inform treatment in different groups of adolescents.

show abstract

Resting-State Connectivity Predictors of Response to Psychotherapy in Major Depressive Disorder

Cited by 117 publications

References 141 publications

“Engage” therapy: Prediction of change of late-life major depression

“Engage” therapy: Prediction of change of late-life major depression

“Engage” Therapy: Behavioral Activation and Improvement of Late-Life Major Depression

The ABCD Study of Neurodevelopment: Identifying Neurocircuit Targets for Prevention and Treatment of Adolescent Substance Abuse

Contact Info

Product

Resources

About