Responsiveness of the National Eye Institute Visual Function Questionnaire to Progression to Advanced Age-Related Macular Degeneration, Vision Loss, and Lens Opacity

Abstract

Objective: To describe the ability of the National Eye Institute Visual Function Questionnaire (NEI-VFQ) to detect meaningful change over time (responsiveness) to the primary Age-Related Eye Disease Study outcomes. Methods:The 25-item NEI-VFQ plus appendix was administered at 2 visits at 1-to 4-year intervals to 4119 participants in the Age-Related Eye Disease Study. Events evaluated were progression to advanced age-related macular degeneration (AMD), visual acuity (VA) loss of at least 15 letters, and lens opacity progression. Responsiveness was measured by the t statistic, effect size (ES), responsiveness statistic, and area under the receiver operating characteristic curve. Variance components were used to estimate the contributions of events to variability of the NEI-VFQ score.

Association of National Eye Institute Visual Function Questionnaire 39 Scores With Visual Function in Age-related Macular Degeneration Over 24 Months

“…General vision and near activities subscales differentiated eAMD and iAMD from normal participants, but did not change with AMD progression. Previous studies demonstrated inverse association between progression to advanced AMD and driving scores, as increasing deficits in central acuity, as developed in AMD, may result in lower driving values 6,29,30. Our results aligned with these findings, as iAMD patients scored lower than eAMD patients on baseline NEI-VFQ39 driving subscale.…”

“…Previous studies demonstrated inverse association between progression to advanced AMD and driving scores, as increasing deficits in central acuity, as developed in AMD, may result in lower driving values. 6,29,30 Our results aligned with these findings, as iAMD patients scored lower than eAMD patients on baseline NEI-VFQ39 driving subscale. Peripheral vision was significantly impacted in iAMD participants compared to controls, an expected result given rod degeneration as AMD advances.…”

Association of National Eye Institute Visual Function Questionnaire 39 Scores With Visual Function in Age-related Macular Degeneration Over 24 Months

“…General vision and near activities subscales differentiated eAMD and iAMD from normal participants, but did not change with AMD progression. Previous studies demonstrated inverse association between progression to advanced AMD and driving scores, as increasing deficits in central acuity, as developed in AMD, may result in lower driving values 6,29,30. Our results aligned with these findings, as iAMD patients scored lower than eAMD patients on baseline NEI-VFQ39 driving subscale.…”

“…Previous studies demonstrated inverse association between progression to advanced AMD and driving scores, as increasing deficits in central acuity, as developed in AMD, may result in lower driving values. 6,29,30 Our results aligned with these findings, as iAMD patients scored lower than eAMD patients on baseline NEI-VFQ39 driving subscale. Peripheral vision was significantly impacted in iAMD participants compared to controls, an expected result given rod degeneration as AMD advances.…”

Assessing quality of life in the treatment of patients with age-related macular degeneration: clinical research findings and recommendations for clinical practice

“……”

The quality of life impact of peripheral versus central vision loss with a focus on glaucoma versus age-related macular degeneration

“……”

Association of National Eye Institute Visual Function Questionnaire 39 Scores With Visual Function in Age-related Macular Degeneration Over 24 Months

“…General vision and near activities subscales differentiated eAMD and iAMD from normal participants, but did not change with AMD progression. Previous studies demonstrated inverse association between progression to advanced AMD and driving scores, as increasing deficits in central acuity, as developed in AMD, may result in lower driving values 6,29,30. Our results aligned with these findings, as iAMD patients scored lower than eAMD patients on baseline NEI-VFQ39 driving subscale.…”

“…Previous studies demonstrated inverse association between progression to advanced AMD and driving scores, as increasing deficits in central acuity, as developed in AMD, may result in lower driving values. 6,29,30 Our results aligned with these findings, as iAMD patients scored lower than eAMD patients on baseline NEI-VFQ39 driving subscale. Peripheral vision was significantly impacted in iAMD participants compared to controls, an expected result given rod degeneration as AMD advances.…”

Assessing quality of life in the treatment of patients with age-related macular degeneration: clinical research findings and recommendations for clinical practice

“……”

The quality of life impact of peripheral versus central vision loss with a focus on glaucoma versus age-related macular degeneration

“……”

Association of National Eye Institute Visual Function Questionnaire 39 Scores With Visual Function in Age-related Macular Degeneration Over 24 Months

“…General vision and near activities subscales differentiated eAMD and iAMD from normal participants, but did not change with AMD progression. Previous studies demonstrated inverse association between progression to advanced AMD and driving scores, as increasing deficits in central acuity, as developed in AMD, may result in lower driving values 6,29,30. Our results aligned with these findings, as iAMD patients scored lower than eAMD patients on baseline NEI-VFQ39 driving subscale.…”

“…Previous studies demonstrated inverse association between progression to advanced AMD and driving scores, as increasing deficits in central acuity, as developed in AMD, may result in lower driving values. 6,29,30 Our results aligned with these findings, as iAMD patients scored lower than eAMD patients on baseline NEI-VFQ39 driving subscale. Peripheral vision was significantly impacted in iAMD participants compared to controls, an expected result given rod degeneration as AMD advances.…”

Assessing quality of life in the treatment of patients with age-related macular degeneration: clinical research findings and recommendations for clinical practice

“……”

The quality of life impact of peripheral versus central vision loss with a focus on glaucoma versus age-related macular degeneration

“……”