We appreciate the comments on the article ' Normal perfusion pressure breakthrough phenomenon: what still remains unknown ' 1 that TA Mattei kindly made in this letter. 2 As the author states, two main theories have been postulated so far in order to explain the development of oedema and/or multifocal haemorrhage after the obliteration of intracranial arteriovenous malformations (AVMs). On one hand, ' normal perfusion pressure breakthrough (NPPB) phenomenon ' is based on the loss of cerebral vessel autoregula…
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