Response surface methodology for aqueous two-phase system extraction: An unprecedented approach for the specific flavonoid-rich extraction of Houttuynia cordata Thunb. leaves towards acne treatment

Nguyen, Minh Hien; Nguyen, Lan Thi; Nguyen Le, Thien Han; Ngoc Chau, Trong Nghia; Thi Nguyen, Yen Nhi; Ha, Tan Dat; Tran Nguyen, Phuoc Thuan; Chu, Thien Bao; Tran, Chi Hieu; Le, Minh Tri

doi:10.1016/j.heliyon.2024.e25245

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e25245

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Response surface methodology for aqueous two-phase system extraction: An unprecedented approach for the specific flavonoid-rich extraction of Houttuynia cordata Thunb. leaves towards acne treatment

Minh Hien Nguyen,

Lan Thi Nguyen,

Thien Han Nguyen Le

et al.

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2024

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Cited by 2 publications

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Optimization and component identification of ultrasound‐assisted extraction of functional compounds from waste blackberry (Rubus fruticosus Pollich) seeds

Yang,

Wang,

Zhou

et al. 2024

J Sci Food Agric

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BACKGROUNDBlackberry seeds, as a by‐product of processing, have potential bioactive substances and activities. A response surface method was used to determine the optimal conditions of blackberry seed extracts (BSEs) with high 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) scavenging activity by ultrasound‐assisted extraction (UAE). The composition and antioxidant capacity of BSEs were further analyzed.RESULTSThe optimal conditions were material‐to‐liquid ratio of 0.07 g mL−1, ethanol concentration of 56%, extraction temperature of 39 °C and ultrasonic power of 260 W. Using these conditions, the extraction yield and total polysaccharide, phenolic and anthocyanin contents in BSEs were 0.062 g g−1 and 633.91, 36.21 and 3.07 mg g−1, respectively. The Fourier transform infrared spectra of BSEs exhibited characteristic peaks associated with polysaccharide absorption. The antioxidant capacity, DPPH and 2,2'‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) radical scavenging activity, and ferric reducing antioxidant power of BSEs were 1533.19, 1021.93 and 1093.38 mmol Trolox equivalent g−1, respectively. The delphinidin‐3‐O‐glucoside, paeoniflorin‐3‐O‐glucoside and cyanidin‐3‐O‐arabinoside contents in BSEs were 3.05,12.76 and 1895.90 ± 3.45 μg g−1. Five polyphenols including gallic acid, coumaric acid, ferulic acid, catechin and caffeic acid were identified and quantified in BSEs with its contents at 8850.43, 5053.26, 4984.65, 1846.91 and 192.40 μg g−1.CONCLUSIONThese results provide a method for preparing BSE containing functional components such as polysaccharides, phenols and anthocyanins through UAE, and BSEs have potential application in food industries. © 2024 Society of Chemical Industry.

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Optimization and component identification of ultrasound‐assisted extraction of functional compounds from waste blackberry (Rubus fruticosus Pollich) seeds

Yang,

Wang,

Zhou

et al. 2024

J Sci Food Agric

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Optimization of Extraction of Four Components from Radix Scrophulariae with Natural Deep Eutectic Solvents and Evaluation of Extract’s Antioxidant Activity

Huang,

Zhou,

Ruan

et al. 2024

Journal of Chromatographic Science

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In this research, eight natural deep eutectic solvents (NaDESs) consisting of food-grade ingredients were screened for the extraction of four bioactive compounds (acteoside, cinnamic acid, angoroside C and harpagoside) from radix scrophulariae (RS). Among these NaDESs, Proline-Glycerol NaDES with higher comprehensive score was selected. The Criteria Importance Through Intercriteria Correlation (CRITIC) was applied to calculate the information entropy and the weight of indexes, and figured out a comprehensive score. The weights of acteoside, cinnamic acid, angoroside C and harpagoside were 0.369, 0.172, 0.241 and 0.218, respectively. Response surface methodology (RSM) mathematical model was used to optimize the extraction parameters. The optimal extraction parameters were as follows: extraction time with 42.21 min, NaDES concentration with 52.89%, solid-to-liquid ratio with 1 : 37.05 g/mL and the predicted value of comprehensive score was 0.885. Under the optimal condition, the comprehensive score was 0.903 ± 0.005. Finally, the antioxidant activity experiment revealed that the 1,1-Diphenyl-2-picrylhydrazyl · radical scavenging activity and hydroxyl radical scavenging activity of the extract at 2.0 mg/mL and 1.5 mg/mL were approximately equal to those of ascorbic acid, respectively. The results showed that the extraction condition optimized by RSM combined with CRITIC was reasonable and dependable, and the extract of radix scrophulariae exhibited good antioxidant activity.

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Response surface methodology for aqueous two-phase system extraction: An unprecedented approach for the specific flavonoid-rich extraction of Houttuynia cordata Thunb. leaves towards acne treatment

Cited by 2 publications

References 36 publications

Optimization and component identification of ultrasound‐assisted extraction of functional compounds from waste blackberry (Rubus fruticosus Pollich) seeds

Optimization and component identification of ultrasound‐assisted extraction of functional compounds from waste blackberry (Rubus fruticosus Pollich) seeds

Optimization of Extraction of Four Components from Radix Scrophulariae with Natural Deep Eutectic Solvents and Evaluation of Extract’s Antioxidant Activity

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