1963
DOI: 10.1677/joe.0.0260517
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: The effects of testosterone propionate (TP) and of 17\g=a\-ethyl-19 nor-testo\x=req-\ sterone (ENT) on the submandibular glands, levator ani muscles and seminal vesicles of castrated mice have been compared. ENT restores submandibular weight and histology about as well as TP but has less effect on the levator ani muscle and much less effect on the seminal vesicles.Both steroids can act directly on the submandibular gland. It is suggested that the effect on the gland may be an indication of the 'anabolic' rathe… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

1981
1981
1983
1983

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 13 publications
(2 citation statements)
references
References 8 publications
(9 reference statements)
0
2
0
Order By: Relevance
“…Marked effects on the submandibular gland of castrated mice have also been found with anabolic steroids, such as norethandrolone (Brown-Grant & Taylor, 1963), nandrolone phenylpropionate, decanoate, androstanolone, methandrostanelone, oxymetholone (Houssay, de Harfin, Montuori & Epper, 1966) and 19-nortestosterone which have little or only a weak effect on the prostate. Cyproterone acetate, a competitive antagonist of androgen, also shows androgenic action on the submandibular gland of castrated-adrenalectomized mice but not on the prostate (Sato, Chen & Maruyama, 1979).…”
Section: Discussionmentioning
confidence: 99%
“…Marked effects on the submandibular gland of castrated mice have also been found with anabolic steroids, such as norethandrolone (Brown-Grant & Taylor, 1963), nandrolone phenylpropionate, decanoate, androstanolone, methandrostanelone, oxymetholone (Houssay, de Harfin, Montuori & Epper, 1966) and 19-nortestosterone which have little or only a weak effect on the prostate. Cyproterone acetate, a competitive antagonist of androgen, also shows androgenic action on the submandibular gland of castrated-adrenalectomized mice but not on the prostate (Sato, Chen & Maruyama, 1979).…”
Section: Discussionmentioning
confidence: 99%
“…19 The possibility has been raised that this hormonal effect is the consequence of an anabolic action rather than a specific androgenic response. [10][11][12][13] In the submandibular salivary glands of the rat, high doses of both 17,B-estradiol and diethylstilbestrol decrease the size of the convoluted granular tubules in a comparable manner to gonadectomy.14-16 Since such large doses of estrogen will also exert an anabolic effect, it would appear that the inhibitory action of this group of steroid hormones upon the salivary glands is a specific estrogenic property. The oxidation potential of 1 73-estradiol is on the order of 500 mV, and it could therefore react with ductal peroxidase, thus inhibiting normal function and development.…”
Section: Introductionmentioning
confidence: 99%