Response of rabbit detrusor muscle to total extract and major alkaloids of Hydrastis canadensis

Goldenseal (Hydrastis canadensis): Is There Enough Scientific Evidence to Support Safety and Efficacy?

“…An ethanol extract of goldenseal root inhibited carbachol‐induced contractions of isolated guinea pig trachea, isoproterenol‐induced contractions in rabbit detrusor muscle strips, serotonin‐induced contractions of guinea pig aorta, and norepinephrine‐ or phenylephrine‐induced contractions in isolated rabbit prostate strips in vitro. 32–35 Again, berberine appears to be the active constituent, as it induces relation of norepinephrine‐precontracted isolated rat aorta and of isolated precontracted rat mesenteric arteries at a concentration of 10 −5 M 36,37 …”

“…An ethanol extract of goldenseal root inhibited carbachol-induced contractions of isolated guinea pig trachea, isoproterenol-induced contractions in rabbit detrusor muscle strips, serotonin-induced contractions of guinea pig aorta, and norepinephrine-or phenylephrine-induced contractions in isolated rabbit prostate strips in vitro. [32][33][34][35] Again, berberine appears to be the active constituent, as it induces relation of norepinephrine-precontracted isolated rat aorta and of isolated precon-tracted rat mesenteric arteries at a concentration of 10 Ϫ5 M. 36,37 Goldenseal extracts appear to have some positive effect on the immune response. Intragastric administration of an extract of the crude drug to rats for 6 weeks slightly increased the production of antigen-specific immunoglobulin M. 38 However, it was not as effective as Echinacea in this study.…”

Goldenseal (Hydrastis canadensis): Is There Enough Scientific Evidence to Support Safety and Efficacy?

“…An ethanol extract of goldenseal root inhibited carbachol‐induced contractions of isolated guinea pig trachea, isoproterenol‐induced contractions in rabbit detrusor muscle strips, serotonin‐induced contractions of guinea pig aorta, and norepinephrine‐ or phenylephrine‐induced contractions in isolated rabbit prostate strips in vitro. 32–35 Again, berberine appears to be the active constituent, as it induces relation of norepinephrine‐precontracted isolated rat aorta and of isolated precontracted rat mesenteric arteries at a concentration of 10 −5 M 36,37 …”

“…An ethanol extract of goldenseal root inhibited carbachol-induced contractions of isolated guinea pig trachea, isoproterenol-induced contractions in rabbit detrusor muscle strips, serotonin-induced contractions of guinea pig aorta, and norepinephrine-or phenylephrine-induced contractions in isolated rabbit prostate strips in vitro. [32][33][34][35] Again, berberine appears to be the active constituent, as it induces relation of norepinephrine-precontracted isolated rat aorta and of isolated precon-tracted rat mesenteric arteries at a concentration of 10 Ϫ5 M. 36,37 Goldenseal extracts appear to have some positive effect on the immune response. Intragastric administration of an extract of the crude drug to rats for 6 weeks slightly increased the production of antigen-specific immunoglobulin M. 38 However, it was not as effective as Echinacea in this study.…”

High‐performance liquid chromatography determination of hydrastine and berberine in dietary supplements containing goldenseal

“…The common structure/function label claim of such products is to maintain a healthy immune function during the flu season. Extracts of H. canadensis were found to possess antibacterial, antimalarial, and smooth muscle relaxant activities 4–7. The pharmacological and antimicrobial effects of the extracts are mainly attributed to the high content of the isoquinoline alkaloids, hydrastine and berberine (Figure 1), even though their oral bioavailability is low 2,8.…”

Goldenseal (Hydrastis canadensis): Is There Enough Scientific Evidence to Support Safety and Efficacy?

“…An ethanol extract of goldenseal root inhibited carbachol‐induced contractions of isolated guinea pig trachea, isoproterenol‐induced contractions in rabbit detrusor muscle strips, serotonin‐induced contractions of guinea pig aorta, and norepinephrine‐ or phenylephrine‐induced contractions in isolated rabbit prostate strips in vitro. 32–35 Again, berberine appears to be the active constituent, as it induces relation of norepinephrine‐precontracted isolated rat aorta and of isolated precontracted rat mesenteric arteries at a concentration of 10 −5 M 36,37 …”

“…An ethanol extract of goldenseal root inhibited carbachol-induced contractions of isolated guinea pig trachea, isoproterenol-induced contractions in rabbit detrusor muscle strips, serotonin-induced contractions of guinea pig aorta, and norepinephrine-or phenylephrine-induced contractions in isolated rabbit prostate strips in vitro. [32][33][34][35] Again, berberine appears to be the active constituent, as it induces relation of norepinephrine-precontracted isolated rat aorta and of isolated precon-tracted rat mesenteric arteries at a concentration of 10 Ϫ5 M. 36,37 Goldenseal extracts appear to have some positive effect on the immune response. Intragastric administration of an extract of the crude drug to rats for 6 weeks slightly increased the production of antigen-specific immunoglobulin M. 38 However, it was not as effective as Echinacea in this study.…”

High‐performance liquid chromatography determination of hydrastine and berberine in dietary supplements containing goldenseal

“…The common structure/function label claim of such products is to maintain a healthy immune function during the flu season. Extracts of H. canadensis were found to possess antibacterial, antimalarial, and smooth muscle relaxant activities 4–7. The pharmacological and antimicrobial effects of the extracts are mainly attributed to the high content of the isoquinoline alkaloids, hydrastine and berberine (Figure 1), even though their oral bioavailability is low 2,8.…”

Goldenseal (Hydrastis canadensis): Is There Enough Scientific Evidence to Support Safety and Efficacy?

“…An ethanol extract of goldenseal root inhibited carbachol‐induced contractions of isolated guinea pig trachea, isoproterenol‐induced contractions in rabbit detrusor muscle strips, serotonin‐induced contractions of guinea pig aorta, and norepinephrine‐ or phenylephrine‐induced contractions in isolated rabbit prostate strips in vitro. 32–35 Again, berberine appears to be the active constituent, as it induces relation of norepinephrine‐precontracted isolated rat aorta and of isolated precontracted rat mesenteric arteries at a concentration of 10 −5 M 36,37 …”

“…An ethanol extract of goldenseal root inhibited carbachol-induced contractions of isolated guinea pig trachea, isoproterenol-induced contractions in rabbit detrusor muscle strips, serotonin-induced contractions of guinea pig aorta, and norepinephrine-or phenylephrine-induced contractions in isolated rabbit prostate strips in vitro. [32][33][34][35] Again, berberine appears to be the active constituent, as it induces relation of norepinephrine-precontracted isolated rat aorta and of isolated precon-tracted rat mesenteric arteries at a concentration of 10 Ϫ5 M. 36,37 Goldenseal extracts appear to have some positive effect on the immune response. Intragastric administration of an extract of the crude drug to rats for 6 weeks slightly increased the production of antigen-specific immunoglobulin M. 38 However, it was not as effective as Echinacea in this study.…”

High‐performance liquid chromatography determination of hydrastine and berberine in dietary supplements containing goldenseal

“…The common structure/function label claim of such products is to maintain a healthy immune function during the flu season. Extracts of H. canadensis were found to possess antibacterial, antimalarial, and smooth muscle relaxant activities 4–7. The pharmacological and antimicrobial effects of the extracts are mainly attributed to the high content of the isoquinoline alkaloids, hydrastine and berberine (Figure 1), even though their oral bioavailability is low 2,8.…”