Response of Murine and Normal Human Skin to Injection of Allogeneic Blood-Derived Psoriatic Immunocytes

Human Natural Killer T Cells Infiltrate into the Skin at Elicitation Sites of Allergic Contact Dermatitis

“…Our frequency analysis of NKT cells indicated that the frequency of NKT cells in ACD may be similar to that previously reported in psoriasis (Liao et al, 2006). Considering the proposed pathogenic role of NKT cells in psoriasis (Nickoloff et al, 1999), and the striking parallels we have identified in ACD with psoriasis (presence, distribution, and frequency of NKT cells in lesions), it is worth considering that NKT cells contribute to the pathophysiology of the elicitation phase of human CHS. Previous studies suggested that NKT cells played an indispensable role in the early molecular events of CHS (Campos et al, 2003).…”

Comparison of the T Cell Patterns in Leprous and Cutaneous Sarcoid Granulomas

“…CD1b and CD1c stained positive for epidermal cells only occasionally, without showing associations with one of the investigated disorders. Some of the biopsies showed positive staining of CD1d, also in the basal layer of the epidermis, suggesting an expression of this molecule by human keratinocytes, as described earlier, 31 but this pattern was seen for leprosy and sarcoidosis patients and was also found in the uninvolved skin of healthy control subjects. The positive staining pattern was paralleled by the detection of CD1d-RNA by RT-PCR in all sarcoidosis and TCR leprosy patients (data not shown).…”

Novel nanosome delivery system combined with siRNA targeting the antimicrobial gene DFB4: a new approach for psoriasis management?

“…Similarly, Nickoloff et al. and our group have shown that injection of allogeneic immunocytes bearing NK receptors into the normal skin of healthy volunteers grafted onto SCID mice robustly induces psoriatic features (and this without any evidence of graft‐versus‐host disease‐associated phenomena).…”